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UCLA wins $4.8 million NIH grant to develop methods for improving polygenic risk scores

UCLA Health will receive a $4.8 million grant from The National Institutes of Health to develop methods that will improve genetic risk estimates - polygenic risk scores - for specific diseases in people from diverse populations and mixed ancestries.

16 Jun 2021

Scientists reveal the mechanism of liquid-liquid phase separation of SARS-CoV-2 nucleocapsid

A team of scientists from the United States has recently revealed how interactions between the SARS-CoV-2 nucleocapsid protein and the double-stranded RNA motifs impart distinct droplet properties that can support multiple viral functions. The study is currently available on the bioRxiv* preprint server.

16 Jun 2021

Increased viral replication and shedding in nonhuman primates carrying SARS-CoV-2 B.1.1.7 variant

A team of researchers from the US and UK used the AGM intranasal model of SARS-CoV-2 infection to determine differences between a contemporary SARS-CoV-2 D614G variant circulating in summer 2020 and the B.1.1.7 UK variant of concern that emerged in late 2020.

16 Jun 2021

A study on SARS-CoV-2 proteins for the development of COVID-19 drugs

The authors of the review have grouped the virus proteins into three categories, (a) host-entry, (b) self-acting, and (c) host-interacting. Additionally, individual SARS-CoV-2 proteins are evaluated to be either directly targeted by drugs or block virus-host interactions.

16 Jun 2021

Rapidly evolving SARS-Cov-2 strains may give rise to escape variants

The number of COVID-19 variants is growing rapidly, so much that the scale and scope of mutation may pose a threat to the continuing successful use of the current vaccines and therapies.

16 Jun 2021

Studies shed new light on disease processes in tuberculosis

Two new studies have cast unprecedented light on disease processes in tuberculosis, identifying key genetic changes that cause damage in the lungs and a drug treatment that could speed up recovery.

16 Jun 2021

Study uncovers novel drug that effectively thwarts pancreatic tumors

Pancreatic cancer is an aggressive disease in which malignant cells form in the tissues of the pancreas, a long and flat gland located behind the stomach that helps with digestion and blood sugar regulation.

14 Jun 2021

Researchers develop new imaging technique for studying nanoscale coronavirus-host interactions

Lei S. Qi of Stanford University, California, and colleagues published research showing a potential framework to better characterize coronaviruses' biology. While most high-resolution imaging techniques show the life cycle of coronaviruses, identifying viral or host proteins and genomes remains poorly understood. Their results use multi-color super-resolution imaging allows them to study nanoscopic parts of the coronavirus, including RNA.

14 Jun 2021

Artificial intelligence for predicting TMB-H colorectal cancer from histopathological characteristics

Biomarkers are important determinants of appropriate and effective therapeutic approaches for various diseases including cancer.

14 Jun 2021

UCSF launches new initiative to propel the development of living therapeutics

UC San Francisco is launching a new initiative to propel the development of living therapeutics - a category of treatments broadly defined as human and microbial living cells that are selected, modified, or engineered to treat or cure disease - and bring them quickly to patients.

14 Jun 2021

Delays and shortages hit SARS-CoV-2 genomic surveillance program

A new study from the Institute of Bioinformatics and Applied Biotechnology (IBAB), Bengaluru, India, provides an overview of how well this important monitoring mechanism is functioning around the world. The team has released their findings as a preprint on the bioRxiv* server.

14 Jun 2021

Emerging SARS-CoV-2 variants contain mutations that interfere with genomic sequencing

A recent study by researchers in Canada shows how mutations in newly emerging lineages of SARS-CoV-2 may disrupt the sequencing process and thus interfere with this important area of research.

14 Jun 2021

New technique uses high-throughput sequencing to obtain ultra-high-resolution images of gene expression

The 30,000 or so genes making up the human genome contain the instructions vital to life. Yet each of our cells expresses only a subset of these genes in their daily functioning. The difference between a heart cell and a liver cell, for example, is determined by which genes are expressed--and the correct expression of genes can mean the difference between health and disease.

11 Jun 2021

Researchers develop new method to make CRISPR gene editing more precise

CRISPR Researchers from Aarhus University and University of Copenhagen have developed a new method, which makes CRISPR gene editing more precise than conventional methods.

10 Jun 2021

Study reveals new insights into how genes are regulated in dementia

The largest study of its kind has unveiled new insights into how genes are regulated in dementia, including discovering 84 new genes linked to the disease.

10 Jun 2021

Rapamycin targets gut cells to alter the way DNA is stored

Our genetic material is stored in our cells in a specific way to make the meter-long DNA molecule fit into the tiny cell nucleus of each body cell.

10 Jun 2021

Eldelumab and Fenofibrate show potential for COVID-19

In a new study posted to the medRxiv* preprint server, researchers from the University of Pittsburgh and Barrow Neurological Institute report the results of their analysis of several RNA-Seq studies and used computational approaches to discover potential drugs against COVID-19.

10 Jun 2021

Research clarifies neuron-specific DNA methylation changes and characteristics in bipolar disorder

A research collaboration based in Kumamoto University, Japan has revealed the DNA methylation status of gene transcriptional regulatory regions in the frontal lobes of patients with bipolar disorder (BD).

9 Jun 2021

SARS-CoV-2 enzyme inhibitors among drugs screened for repurposing

A new bioRxiv* preprint describes the identification of some promising pharmaceutical compounds that could be developed as antiviral drugs against COVID-19.

9 Jun 2021

Researchers in Canada conduct a comparative study of household secondary attack rates connected with SARS-CoV-2 variants of concern

Scientists are considering a third surge in COVID-19 incidence owing to the emergence of highly transmissible SARS-CoV-2 variants of concern (VOC). SARS-CoV-2 is the causal agent of the current COVID-19 pandemic. Some of these VOCs have been reported to have a rate of transmission much higher than the infectivity of the ancestral strain that had emerged in Wuhan, China, in 2019.

9 Jun 2021

Genome News and Research

UCLA wins $4.8 million NIH grant to develop methods for improving polygenic risk scores

Scientists reveal the mechanism of liquid-liquid phase separation of SARS-CoV-2 nucleocapsid

Increased viral replication and shedding in nonhuman primates carrying SARS-CoV-2 B.1.1.7 variant

A study on SARS-CoV-2 proteins for the development of COVID-19 drugs

Rapidly evolving SARS-Cov-2 strains may give rise to escape variants

Studies shed new light on disease processes in tuberculosis

Study uncovers novel drug that effectively thwarts pancreatic tumors

Researchers develop new imaging technique for studying nanoscale coronavirus-host interactions

Artificial intelligence for predicting TMB-H colorectal cancer from histopathological characteristics

UCSF launches new initiative to propel the development of living therapeutics

Delays and shortages hit SARS-CoV-2 genomic surveillance program

Emerging SARS-CoV-2 variants contain mutations that interfere with genomic sequencing

New technique uses high-throughput sequencing to obtain ultra-high-resolution images of gene expression

Researchers develop new method to make CRISPR gene editing more precise

Study reveals new insights into how genes are regulated in dementia

Rapamycin targets gut cells to alter the way DNA is stored

Eldelumab and Fenofibrate show potential for COVID-19

Research clarifies neuron-specific DNA methylation changes and characteristics in bipolar disorder

SARS-CoV-2 enzyme inhibitors among drugs screened for repurposing

Researchers in Canada conduct a comparative study of household secondary attack rates connected with SARS-CoV-2 variants of concern

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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