Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

BU professor wins RF1 $3.2M grant for age-related neuropathology research

Tara Moore, PhD, professor of anatomy & neurobiology at Boston University Chobanian & Avedisian School of Medicine, has been awarded a five-year, RF1 $3.2M grant from the NIH's National Institute of Aging for her project "Extracellular vesicle treatment and age-related neuropathology in non-human primates."

11 Sep 2025

Compact bNIRS technology could become a diagnostic toolkit for dementia

Early and accurate diagnosis of dementia remains a major challenge. Standard approaches such as MRI and PET scans can provide valuable information about brain structure and function, but they are expensive, not always accessible, and often too expensive for repeated use.

11 Sep 2025

SLIT2 protein levels in the eye and blood linked to cognitive function

Neurocognitive impairments are classified by pathological changes with potential for destruction of neural tissue. One change known to occur in neurodegenerative disorders is an accumulation of proteins causing pathological damage.

11 Sep 2025

Chronic insomnia linked to faster cognitive decline and brain changes

People with chronic insomnia may experience faster declines in memory and thinking skills as they age-along with brain changes that can be seen on imaging scans-than people who do not have chronic insomnia, according to a study published in the September 10, 2025, issue of Neurology, the medical journal of the American Academy of Neurology.

10 Sep 2025

Rare ABCA7 gene variants linked to Alzheimer’s risk

A new study from MIT neuroscientists reveals how rare variants of a gene called ABCA7 may contribute to the development of Alzheimer's in some of the people who carry it.

10 Sep 2025

Special MRI technique predicts onset of mild cognitive impairment and cognitive decline

A special MRI technique that detects iron levels in different regions of the brain can predict the onset of mild cognitive impairment and cognitive decline in cognitively unimpaired older adults, potentially creating a pathway to earlier interventions, according to a study published today in Radiology, a journal of the Radiological Society of North America.

9 Sep 2025

Berberine improves cognitive function in diabetic encephalopathy mice

A recent study published in Engineering has shed new light on the potential therapeutic effects of berberine (BBR), a natural compound derived from traditional Chinese medicine, in treating diabetic encephalopathy (DE).

9 Sep 2025

Air pollution exposure linked to faster progression of Alzheimer’s disease

Exposure to high concentrations of air pollution may worsen Alzheimer's disease (AD) by accelerating the buildup of toxic proteins in the brain and speeding up cognitive decline.

8 Sep 2025

Study could pave the way for simple blood test to diagnose Alzheimer's disease

In a landmark study of Hispanic and Latino adults, researchers at University of California San Diego School of Medicine have identified a link between self-reported cognitive decline and blood-based biomarkers, which could pave the way for a simple blood test to help diagnose Alzheimer's disease and related dementias.

8 Sep 2025

Blood-based biomarkers reveal barriers to diversity in Alzheimer’s disease trials

Some of the populations with the highest risk for Alzheimer's disease remain greatly underrepresented in clinical trials-and a new study helps explain why.

5 Sep 2025

Impaired spatial orientation found in older adults at risk for Alzheimer’s disease

Individuals with an increased risk for dementia due to Alzheimer's disease can have impaired spatial orientation skills.

3 Sep 2025

Genetic variant disrupts brain’s cleanup crew increasing Alzheimer’s risk

A Nature study published today and led by researchers at the University of South Florida's USF Health Byrd Alzheimer's Institute pinpoints how a genetic variant disrupts microglia - the brain's "cleanup crew" - increasing the risk of Alzheimer's disease.

3 Sep 2025

Epigenomic erosion linked to cognitive decline in Alzheimer’s patients

Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins.

2 Sep 2025

New insights into early brain circuit breakdown in Alzheimer’s

One of the first parts of the brain affected by Alzheimer's disease is the entorhinal cortex - a region that plays a big role in memory, spatial navigation, and the brain's internal mapping system.

2 Sep 2025

Brain pulsations driving glymphatic function differ in narcolepsy patients and healthy individuals

A hormone produced by the brain, orexin, may play a central role in the functioning of the brain’s glymphatic system, which clears waste, according to a new study from the University of Oulu.

1 Sep 2025

Glutamate receptors found to drive pediatric brain tumor development

The most common type of brain tumor in children, pilocytic astrocytoma (PA), accounts for about 15% of all pediatric brain tumors.

1 Sep 2025

Exploring testosterone's influence on cardiovascular, metabolic, reproductive, and mental health

For decades, testosterone has been recognized as the primary driver of male reproductive development and secondary sex characteristics.

1 Sep 2025

KRISS develops ultra-sensitive platform to detect Alzheimer’s biomarkers in body fluids

The Korea Research Institute of Standards and Science (KRISS, President Lee Ho Seong) has developed a diagnostic platform that amplifies the unique optical signals of molecules by more than a hundred million times, enabling the precise detection and quantification of trace amounts of Alzheimer's disease biomarkers in body fluids.

1 Sep 2025

How plant compounds could target Alzheimer’s disease from multiple angles

This review highlights how dietary polyphenols modulate Alzheimer’s disease biology through antioxidant, anti-inflammatory, and multi-target mechanisms, supported by in-silico docking analyses. Despite promise, challenges in bioavailability and brain delivery remain key hurdles to clinical translation.

31 Aug 2025

Discovery of mitochondrial microprotein opens path to obesity and aging therapies

Like bees breathing life into gardens, providing pollen and making flowers blossom, little cellular machines called mitochondria breathe life into our bodies, buzzing with energy as they produce the fuel that powers each of our cells.

29 Aug 2025

Alzheimer's Disease News and Research

Further Reading

BU professor wins RF1 $3.2M grant for age-related neuropathology research

Compact bNIRS technology could become a diagnostic toolkit for dementia

SLIT2 protein levels in the eye and blood linked to cognitive function

Chronic insomnia linked to faster cognitive decline and brain changes

Rare ABCA7 gene variants linked to Alzheimer’s risk

Special MRI technique predicts onset of mild cognitive impairment and cognitive decline

Berberine improves cognitive function in diabetic encephalopathy mice

Air pollution exposure linked to faster progression of Alzheimer’s disease

Study could pave the way for simple blood test to diagnose Alzheimer's disease

Blood-based biomarkers reveal barriers to diversity in Alzheimer’s disease trials

Impaired spatial orientation found in older adults at risk for Alzheimer’s disease

Genetic variant disrupts brain’s cleanup crew increasing Alzheimer’s risk

Epigenomic erosion linked to cognitive decline in Alzheimer’s patients

New insights into early brain circuit breakdown in Alzheimer’s

Brain pulsations driving glymphatic function differ in narcolepsy patients and healthy individuals

Glutamate receptors found to drive pediatric brain tumor development

Exploring testosterone's influence on cardiovascular, metabolic, reproductive, and mental health

KRISS develops ultra-sensitive platform to detect Alzheimer’s biomarkers in body fluids

How plant compounds could target Alzheimer’s disease from multiple angles

Discovery of mitochondrial microprotein opens path to obesity and aging therapies

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