Therapeutics News and Research

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Mefloquine shows potential as anti-SARS-CoV-2 drug

A team of scientists from Japan has identified the approved anti-material drug, mefloquine, as a potential candidate to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Specifically, mefloquine has been shown to prevent the entry of SARS-CoV-2 into host cells and reduce the viral load in vitro.

24 Nov 2020

Largest clinical trial launched to treat mild-to-moderate COVID-19 patients in Africa

Thirteen African countries and an international network of research institutions have joined forces to launch the largest COVID-19 clinical trial in mild-to-moderate outpatients in Africa.

24 Nov 2020

FairJourney Biologics and IONTAS sign agreement with Pandion Therapeutics to discover antibodies

FairJourney Biologics S.A (FJB) and IONTAS Limited, leaders in the discovery and optimization of VHH and fully human antibodies, today announced they have signed an agreement to discover antibodies with Pandion Therapeutics.

24 Nov 2020

Researchers use single-cell RNA sequence analysis to address the cornea's healing process

The insulation around nerve cell components in our corneas have unique properties, and little is known about them.

24 Nov 2020

First checkpoint inhibitor vaccine shown to be safe, effective in colon cancer animal model

A study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute described a potential therapeutic anticancer vaccine that frees suppressed cancer-killing immune cells, enabling them to attack and destroy a tumor.

23 Nov 2020

Antimicrobial found in soaps worsens fatty liver disease in mice

University of California San Diego School of Medicine researchers found evidence that triclosan -- an antimicrobial found in many soaps and other household items -- worsens fatty liver disease in mice fed a high-fat diet.

23 Nov 2020

Molecular action of tarantula toxin may hold clues to better control of chronic pain

Oversized, hairy tarantulas may be unsightly and venomous, but surprisingly their hunter toxin may hold answers to better control of chronic pain.

23 Nov 2020

Understanding biomolecular frustration could help design better drugs

Knowing precisely where proteins are frustrated could go a long way toward making better drugs.

23 Nov 2020

SARS-CoV-2's spike protein mutations have slowed, study finds

A team of researchers at the School of Information Sciences in Illinois, USA, has revealed the rate of mutation in the 29 proteins that make up the SARS-CoV-2 microbe.

23 Nov 2020

Novel targeted therapy blocks metabolic pathways in cancer cells with specific genetic defects

Researchers at The University of Texas MD Anderson Cancer Center have developed a novel targeted therapy, called POMHEX, which blocks critical metabolic pathways in cancer cells with specific genetic defects.

23 Nov 2020

Researchers develop recombinant SARS-CoV-2 model to aid vaccine and antiviral research

Researchers have developed a fluorescent reporter gene-bearing recombinant form of SARS-CoV-2, which is capable of replication.

23 Nov 2020

Researchers investigate SARS-CoV-2 transmission chain dynamics in the Nordic countries

To date, the coronavirus disease (COVID-19) pandemic has affected over 58.52 million individuals and led to more than 1.38 million deaths worldwide. Second waves of the pandemic are still ongoing in many countries with a massive impact on health care systems and economies.

22 Nov 2020

Researchers discover potential cellular target for eliminating bone breakdown in osteoporosis

New research has discovered a cell type that governs the way bones form and maintain themselves, opening up a potential target for future therapies for bone disorders like osteoporosis.

20 Nov 2020

Texas Biomed awarded $1 million to evaluate MAb therapeutics for COVID-19

Texas Biomedical Research Institute in San Antonio, Texas, was awarded $1 million from the Bill & Melinda Gates Foundation to test the efficacy of human monoclonal antibodies (MAbs) for the treatment of SARS-CoV-2 infection.

19 Nov 2020

New druggable target for heart failure in neonates and infants identified

Researchers have identified a new druggable target for heart failure in neonates and infants, a condition for which there has been no specific treatment.

19 Nov 2020

Research on genetic heart disease uncovers new mechanism for heart failure

Research on genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy.

19 Nov 2020

Alzheimer's study shows tau protein changes according to dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain.

19 Nov 2020

Therapeutics News and Research

Mefloquine shows potential as anti-SARS-CoV-2 drug

Largest clinical trial launched to treat mild-to-moderate COVID-19 patients in Africa

FairJourney Biologics and IONTAS sign agreement with Pandion Therapeutics to discover antibodies

Researchers use single-cell RNA sequence analysis to address the cornea's healing process

First checkpoint inhibitor vaccine shown to be safe, effective in colon cancer animal model

Antimicrobial found in soaps worsens fatty liver disease in mice

Molecular action of tarantula toxin may hold clues to better control of chronic pain

Understanding biomolecular frustration could help design better drugs

SARS-CoV-2's spike protein mutations have slowed, study finds

Novel targeted therapy blocks metabolic pathways in cancer cells with specific genetic defects

Researchers develop recombinant SARS-CoV-2 model to aid vaccine and antiviral research

Researchers investigate SARS-CoV-2 transmission chain dynamics in the Nordic countries

Researchers discover potential cellular target for eliminating bone breakdown in osteoporosis

Texas Biomed awarded $1 million to evaluate MAb therapeutics for COVID-19

New druggable target for heart failure in neonates and infants identified

Research on genetic heart disease uncovers new mechanism for heart failure

Alzheimer's study shows tau protein changes according to dementia stage

TB researchers uncover crucial clue that explains antibiotic resistance in bacteria

New understanding of glycan signatures of the SARS-COV-2 S1 spike protein

A DNA-based nanogel for targeted delivery of therapeutics

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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