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Combination of two drugs shows promise in treating B-cell acute lymphoblastic leukemia

A combination of two drugs could improve outcomes and reduce the need for toxic chemotherapy for B-cell acute lymphoblastic leukemia (B-ALL), the commonest cancer in childhood and one that can be particularly difficult to treat in older patients, according to Cambridge scientists.

20 May 2025

$Testosterone gel fails to boost recovery after hip fracture in women$

Testosterone gel fails to boost recovery after hip fracture in women

Hip fractures, often a result of a fall, are the most serious type of osteoporotic fracture because they are accompanied by considerable pain, loss of muscle and bone strength, reduced mobility and independence with daily activities, and increased risk for future fractures and death.

15 May 2025

Scientists take key step toward developing a preventative HIV vaccine

Worldwide, an estimated 40 million people live with HIV. Two-thirds of this group on the African continent. In 2023, more than 600,000 people died from HIV-related causes and 1.32 million were infected.

15 May 2025

Ubrogepant relieves early migraine symptoms and may help prevent full-blown attacks

A phase 3 trial found that ubrogepant, given during the premonitory phase of migraine, improved common warning symptoms such as fatigue, light and sound sensitivity, and neck pain. These benefits were observed as early as one hour post-treatment, suggesting early intervention can reduce migraine burden.

15 May 2025

Early cardiovascular benefits of semaglutide seen within months in SELECT trial

Semaglutide can rapidly reduce heart attacks and other serious cardiovascular complications in adults with overweight or obesity who have pre-existing cardiovascular disease but not diabetes, according to a secondary analysis of the landmark Semaglutide and Cardiovascular Outcomes (SELECT) trial from the same international author team being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain.

12 May 2025

Chokeberry juice reduces blood vessel resistance in people with pre-diabetes

A German crossover trial found that drinking polyphenol-rich red berry juice improved peripheral resistance and helped preserve muscle mass in pre-diabetic adults. No significant changes were seen in glucose control or oxidative stress over the 14-day interventions.

12 May 2025

GLP-1 receptor agonists improve mood and metabolic health in adults with mental illness

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can lead to significant weight loss and improve blood sugar control in adults with severe mental illness, as well as having positive effects on mood, well-being, and quality of life in those both with and without mental illness, according to a systematic review of the available evidence being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain (11-14 May).

11 May 2025

Obicetrapib slashes LDL cholesterol by over 30% in high-risk heart patients

A large multinational trial published in the New England Journal of Medicine shows that obicetrapib significantly lowers LDL cholesterol in high-risk cardiovascular patients. The CETP inhibitor also improved key lipid parameters with no major safety concerns, supporting its role in future combination therapies.

8 May 2025

Ten-year data confirm exercise is a powerful tool against depression

Researchers review how exercise influences depression in otherwise healthy adults.

7 May 2025

Low-dose rapamycin shows promise for enhancing healthspan in older adults

A new research paper was published in Aging (Aging-US) Volume 17, Issue 4, on April 4, 2025, titled "Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results."

7 May 2025

Combining vagus nerve stimulation with therapy provides lasting PTSD relief

In a first-of-its-kind clinical study, scientists at The University of Texas at Dallas and Baylor University Medical Center showed that patients with treatment-resistant PTSD were symptom-free up to six months after completing traditional therapy paired with vagus nerve stimulation (VNS).

5 May 2025

Semaglutide clears liver inflammation and cuts fibrosis in MASH patients, trial shows

A phase 3 trial shows that once-weekly semaglutide significantly improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH). The interim results also reveal meaningful weight loss and improved cardiometabolic markers, with a favorable safety profile.

4 May 2025

Clinical trial underway to assess effectiveness and safety of potential Long Covid treatment

A clinical trial is underway to assess the effectiveness and safety of sipavibart, AstraZeneca's long-acting monoclonal antibody designed to provide protection against Covid-19, as a potential treatment for Long Covid, the Nova Southeastern University (NSU) and the Schmidt Initiative for Long Covid (SILC) announced today.

1 May 2025

Caffeine increases brain complexity during sleep and shifts it toward a critical state

Caffeine shifts brain activity during sleep by increasing EEG complexity and reducing long-range temporal correlations, particularly in non-REM (NREM) sleep. These changes reflect a movement toward a “critical regime” of neural processing, more pronounced in younger adults.

1 May 2025

Brensocatib once-daily pill shows benefits for chronic lung disease

Results of a large, global clinical trial spanning five continents with over 1,700 patients with bronchiectasis, published this April in the New England Journal of Medicine, demonstrated benefits of an investigational, once-a-day pill called brensocatib as a therapy for the chronic lung condition.

30 Apr 2025

Semaglutide shows promise in treating severe liver disease

Semaglutide effectively treats liver disease in two thirds of patients, new research has found.

30 Apr 2025

Hormone therapy boosts heart health markers but raises some risks

Researchers assess hormone therapy-induced changes in cardiovascular biomarkers.

29 Apr 2025

Why your heart works harder at night after a few drinks, according to new research

Researchers at Ludwig Maximilian University of Munich found that moderate alcohol consumption transiently raises nocturnal resting heart rate without altering objective sleep stages. However, it worsens subjective sleep quality, highlighting subtle cardiovascular stress even at low alcohol doses.

28 Apr 2025

New topical gel reduces painful rash from colorectal cancer treatment

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center and The University of Texas MD Anderson Cancer Center have demonstrated that a novel topical BRAF inhibitor gel called LUT014 significantly reduces the severity of an acne-like rash, a common and painful side effect experienced by patients undergoing anti-EGFR therapies for colorectal cancer.

28 Apr 2025

Erythropoietin fails to improve outcomes for newborns with hypoxic-ischemic encephalopathy

Erythropoietin, a treatment for newborns with critically low levels of oxygen or blood supply to the brain at birth, does not prevent death or disability, according to a new multinational study.

25 Apr 2025

Placebo News and Research

Combination of two drugs shows promise in treating B-cell acute lymphoblastic leukemia

Testosterone gel fails to boost recovery after hip fracture in women

Scientists take key step toward developing a preventative HIV vaccine

Ubrogepant relieves early migraine symptoms and may help prevent full-blown attacks

Early cardiovascular benefits of semaglutide seen within months in SELECT trial

Chokeberry juice reduces blood vessel resistance in people with pre-diabetes

GLP-1 receptor agonists improve mood and metabolic health in adults with mental illness

Obicetrapib slashes LDL cholesterol by over 30% in high-risk heart patients

Ten-year data confirm exercise is a powerful tool against depression

Low-dose rapamycin shows promise for enhancing healthspan in older adults

Combining vagus nerve stimulation with therapy provides lasting PTSD relief

Semaglutide clears liver inflammation and cuts fibrosis in MASH patients, trial shows

Clinical trial underway to assess effectiveness and safety of potential Long Covid treatment

Caffeine increases brain complexity during sleep and shifts it toward a critical state

Brensocatib once-daily pill shows benefits for chronic lung disease

Semaglutide shows promise in treating severe liver disease

Hormone therapy boosts heart health markers but raises some risks

Why your heart works harder at night after a few drinks, according to new research

New topical gel reduces painful rash from colorectal cancer treatment

Erythropoietin fails to improve outcomes for newborns with hypoxic-ischemic encephalopathy

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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