Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Study shows multiplying effects of delirium and dementia in older patients

When hospitalised, people can become acutely confused and disorientated. This condition, known as delirium, affects a quarter of older patients and new research by UCL and the University of Cambridge shows it may have long-lasting consequences, including accelerating the dementia process.

18 Jan 2017

Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy-induced neuropathy and HIV.

18 Jan 2017

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

17 Jan 2017

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.

16 Jan 2017

Functional deficits caused by mini-strokes can last longer than previously thought

Evidence overwhelmingly supports a link between cognitive decline and cerebrovascular diseases such as atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy. Not only do individuals with cerebrovascular diseases have a much higher incidence of cortical microinfarcts (mini-strokes), but post-mortem histological and in vivo radiological studies also find that the burden of microinfarcts is significantly greater among people with vascular cognitive impairment and dementia (VCID) than in age-matched, non-demented individuals.

16 Jan 2017

Study compares two common treatment options for pelvic organ prolapse

Pelvic organ prolapse occurs when the pelvic organs drop from their normal position in the pelvis.

12 Jan 2017

Concussions accelerate Alzheimer's disease-related brain atrophy and cognitive decline, research finds

New research has found concussions accelerate Alzheimer's disease-related brain atrophy and cognitive decline in people who are at genetic risk for the condition.

12 Jan 2017

Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

UT Southwestern Medical Center researchers have identified a protein that is central to the immune system's ability to recognize and destroy the bacterium responsible for the global tuberculosis (TB) epidemic.

12 Jan 2017

Could pathogen infection really lead to Alzheimer’s?

New concepts of infectious disease are evolving with the realization that pathogens are key players in the development of progressive chronic diseases that originally were not thought to be infectious. Infection is well-known to be associated with numerous neurological diseases for which...

12 Jan 2017

Inhibition of EZH2 protein could be new strategy to treat multiple myeloma

In a study published in the scientific journal Oncotarget, researchers from Uppsala University show how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease.

12 Jan 2017

Genes implicated in rare pediatric epilepsy contribute to common forms of disorder, study finds

An international study led by Columbia University Medical Center and NewYork-Presbyterian researchers has found that several genes previously implicated only in rare, severe forms of pediatric epilepsy also contribute to common forms of the disorder.

12 Jan 2017

Scientists discover gene that may open new door to developing treatments for Alzheimer's disease

Scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have identified a gene that may provide a new starting point for developing treatments for Alzheimer's disease (AD).

11 Jan 2017

Hormonal fluctuations make women more sensitive to addictive properties of cocaine, study reveals

Hormonal fluctuations women undergo make them particularly sensitive, compared to men, to the addictive properties of cocaine, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published January 10 in the journal Nature Communications.

11 Jan 2017

New research paves way for better strategies to diagnose and manage vascular graft infections

A rising prevalence of cardiovascular disease has generated substantial growth in the use of medical implants, such as vascular grafts.

11 Jan 2017

Transfusion of ‘oldest blood’ may lead to complications in some patients

The oldest blood available for transfusions releases large and potentially harmful amounts of iron into patients' bloodstreams, a new study by researchers at Columbia University Medical Center has found.

10 Jan 2017

Landmark study unravels secrets of aggressive prostate cancer

A landmark study, led by Monash University's Biomedicine Discovery Institute with the involvement of the Peter MacCallum Cancer Centre, has revealed the reason why men with a family history of prostate cancer who also carry the BRCA2 gene fault have a more aggressive form of prostate cancer.

9 Jan 2017

ATA releases new guidelines for diagnosis, treatment of thyroid disease during pregnancy and postpartum

New evidence-based recommendations from the American Thyroid Association provide guidance to clinicians in diagnosing and managing thyroid disease during pregnancy and the postpartum period.

6 Jan 2017

Penn study finds evidence of AD neuropathology in post-mortem brains of LBD patients

Patients who had a diagnosis of Parkinson's disease (PD) with dementia (PDD) or dementia with Lewy bodies (DLB) and had higher levels of Alzheimer's disease (AD) pathology in their donated post-mortem brains also had more severe symptoms of these Lewy body diseases (LBD) during their lives, compared to those whose brains had less AD pathology, according to research from the Perelman School of Medicine at the University of Pennsylvania.

6 Jan 2017

Uterine microbiome study provides important insights into etiology of endometrial cancer

Endometrial cancer triggers remain elusive, despite continued research. But given the typical inflammatory profile in these cases, microbes in the uterine environment are suspected to play a role in the development of this disease.

6 Jan 2017

Protein involved in neurological disorders can travel from brain to stomach

Researchers of the German Center for Neurodegenerative Diseases have found that "alpha-synuclein", a protein involved in a series of neurological disorders including Parkinson's disease, is capable of travelling from brain to stomach and that it does so following a specific pathway.

5 Jan 2017

Pathology News and Research

Further Reading

Study shows multiplying effects of delirium and dementia in older patients

Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Epigenetic changes drive successful metastases of pancreatic cancer cells

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Functional deficits caused by mini-strokes can last longer than previously thought

Study compares two common treatment options for pelvic organ prolapse

Concussions accelerate Alzheimer's disease-related brain atrophy and cognitive decline, research finds

Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

Could pathogen infection really lead to Alzheimer’s?

Inhibition of EZH2 protein could be new strategy to treat multiple myeloma

Genes implicated in rare pediatric epilepsy contribute to common forms of disorder, study finds

Scientists discover gene that may open new door to developing treatments for Alzheimer's disease

Hormonal fluctuations make women more sensitive to addictive properties of cocaine, study reveals

New research paves way for better strategies to diagnose and manage vascular graft infections

Transfusion of ‘oldest blood’ may lead to complications in some patients

Landmark study unravels secrets of aggressive prostate cancer

ATA releases new guidelines for diagnosis, treatment of thyroid disease during pregnancy and postpartum

Penn study finds evidence of AD neuropathology in post-mortem brains of LBD patients

Uterine microbiome study provides important insights into etiology of endometrial cancer

Protein involved in neurological disorders can travel from brain to stomach

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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