Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Childhood ultra-processed food intake associates with altered insulin responses

Researchers analyzed dietary and metabolic data from 508 nondiabetic Mexican American children in the SAFARI family cohort, finding that higher ultra-processed food scores were associated with lower insulin sensitivity and altered early insulin secretion measures. The exploratory cross-sectional study did not establish causality, and its multiple comparisons, historical dietary data, and questionnaire-based UPF estimates warrant confirmation in longitudinal studies and trials.

21 Jul 2026

Study tests chronotype’s liver link and finds no significant association

Researchers found no significant association between chronotype and FibroScan-derived liver fat or stiffness in 119 medication-naïve adults with overweight or obesity. The exploratory findings cannot exclude smaller effects, particularly for fibrosis, and require confirmation in larger longitudinal studies.

21 Jul 2026

Experts recommend renaming PCOS to better reflect whole-body impacts

A condition affecting approximately 170 million adolescents and women worldwide has a new name – one that better reflects its complexity and far-reaching health impacts.

15 Jul 2026

Bile acid buildup linked to aggressive breast cancer progression

A buildup of bile acids caused by an unhealthy gut can drive breast cancer to other parts of the body, new University of Virginia Comprehensive Cancer Center research reveals.

15 Jul 2026

Lactoferrin yogurt helps preserve iron stores in women with gestational diabetes

In a double-blind pilot trial, lactoferrin-enriched yogurt added to routine iron supplementation helped prevent ferritin decline in pregnant women with gestational diabetes and reduced iron stores. The intervention was well tolerated and produced modest changes in selected gut bacteria, but did not significantly improve anemia or metabolic outcomes.

15 Jul 2026

Breast and prostate cancer survival worsens with metabolic syndrome

A SEER-Medicare analysis of more than 200,000 adults aged 66 and older found that metabolic syndrome was associated with about twice the adjusted hazard of death from any cause after breast or prostate cancer. The condition was also linked to higher cancer-specific, cardiovascular-specific, and liver-failure-specific mortality, although the observational design prevents causal conclusions.

14 Jul 2026

Nine gut bacteria linked to future type 2 diabetes risk

Research identifies specific gut microbes associated with future type 2 diabetes risk, emphasizing the impact of dietary fiber on microbiome health.

9 Jul 2026

LEAP2 hormone may predict anorexia nervosa relapse risk

People with anorexia nervosa have unusually high levels of a hormone called LEAP2 in their blood when they are in the acute phase of the disorder, according to research presented today (Thursday) at the Federation of European Neuroscience Societies (FENS) Forum 2026.

8 Jul 2026

Gut microbiome changes can signal future type 2 diabetes risk

The presence of certain bacteria in the gut microbiota, and fluctuations in a person's metabolism, can be seen in people who go on to develop type 2 diabetes years later.

7 Jul 2026

Six weeks of shorter sleep increases weight and sedentary time

People who shortened their sleep by around 80 minutes a night for six weeks gained weight-one pound on average-and were more sedentary, researchers at Columbia University Vagelos College of Physicians and Surgeons have found.

6 Jul 2026

Depression-like behavior may accelerate endocrine aging in primates

A new review was published in Volume 18 of Aging on June 11, 2026, titled "Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior."

1 Jul 2026

GLP-1 medications may improve long-term health for people with peripheral artery disease

GLP-1 receptor agonists (GLP-1 RA) medications were shown to reduce the number of deaths, amputations and hospitalizations among people with Type 2 diabetes who also had narrowed leg arteries associated with PAD (peripheral artery disease), according to new, independent research published today in the Journal of the American Heart Association, an open-access, peer-reviewed journal of the American Heart Association.

1 Jul 2026

Study links sedentary lifestyle to early mitochondrial dysfunction in adults

Researchers at the University of Colorado Anschutz have found that healthy yet sedentary individuals show a significant, coordinated drop in muscle mitochondrial function that may precede the development of major diseases like cancer, diabetes, and Alzheimer's.

29 Jun 2026

Study links diabetes to worse long COVID health outcomes

People with diabetes who have had COVID-19 tend to recover more slowly, experience more long COVID complications, have a poorer quality of life, and require closer and more prolonged monitoring by medical teams.

29 Jun 2026

Neuroticism and adversity dominate depression and anxiety risk in UK Biobank study

In a UK Biobank study of 87,648 adults followed for 13.7 years, psychosocial factors accounted for the largest estimated population burden of depression and anxiety in both women and men. Neuroticism symptoms, childhood and adult adversity, obesity, chronic inflammation, and some reproductive factors in women were linked to incident mental health outcomes, although the PAF estimates remain theoretical and not proof of causality.

25 Jun 2026

Gene linked to lower BMI points researchers toward a new obesity target

A review in Cardiology in Review highlights GPR75, a receptor for 20-HETE, as a promising therapeutic target for obesity and metabolic syndrome. Evidence from genetic studies, cell experiments, and mouse models suggests that blocking this pathway could influence weight gain, insulin resistance, hypertension, inflammation, and vascular dysfunction.

25 Jun 2026

PMOS rethink reframes a common hormone disorder as a whole-body disease

A new review reframes PCOS, now proposed as PMOS, as a systemic endocrine and metabolic disorder shaped by genetic, epigenetic, ovarian, metabolic, and neuroendocrine pathways. It highlights why inconsistent diagnosis and symptom-focused care have limited progress, while targeted therapies, biomarkers, machine learning, and organ-on-chip models may support more personalized treatment.

18 Jun 2026