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HIF1 protein identified as key driver of tendon pain

Overuse of our tendons can cause painful medical conditions for which only limited treatment options exist. Researchers have now deciphered an important molecular mechanism that triggers these problems.

14 Jan 2026

Disease-responsive nanoparticles enable ghrelin mRNA therapy in osteoarthritis

Nitin Joshi, PhD, and Jingjing Gao, PhD, of the Department of Anesthesiology at Mass General Brigham, are the co-senior authors of a paper published in Nature Nanotechnology, "A disease-severity-responsive nanoparticle enables potent ghrelin mRNA therapy in osteoarthritis." Mahima Dewani, PhD, is the lead author of this study.

14 Jan 2026

Research shows racial-ethnic differences in the risk of pregnancy-related high blood pressure

The risk of pregnancy-related high blood pressure varied markedly among subgroups of Asian American, Native Hawaiian and Pacific Islander people, highlighting the need for tailored prevention and treatment, according to research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

14 Jan 2026

Novel antibody shows promise in overcoming resistance to cancer immunotherapy

According to a Phase I study led by researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Medicine, the novel monoclonal antibody linavonkibart demonstrated the potential to overcome treatment resistance to anti-PD-1 immune checkpoint inhibitors in multiple cancer types.

13 Jan 2026

Epstein-Barr virus together with a gene variant contributes to onset of multiple sclerosis

One of the leading triggers for multiple sclerosis (MS) is an infection with the Epstein-Barr virus. However, certain gene variants also play an important role.

13 Jan 2026

Magnetic torque boosts cardiac organoid maturation, mimicking heart development

Heart disease remains the leading cause of death worldwide, yet progress in understanding and treating cardiac disorders is limited by the shortcomings of existing experimental models.

13 Jan 2026

Short-term, calorie-restrictive diet improves Crohn’s disease symptoms

A Stanford Medicine-led study finds a short-term, calorie-restrictive diet significantly improved symptoms.

13 Jan 2026

New test could improve future diagnosis and monitoring of IBD

A test that rapidly detects signs of inflammatory bowel disease (IBD) in stool samples could improve future diagnosis and monitoring of the condition, a study suggests.

13 Jan 2026

Biohybrid skin graft: A fluorescent window into internal health monitoring

Wearable health devices, such as smartwatches, have become commonplace, enabling the continuous monitoring of physiological signals at the skin's surface.

13 Jan 2026

Vegetarian women show subtle changes in cellular health markers

Slovak university women on vegetarian diets exhibit small bioelectrical impedance variations, suggesting potential insights into body composition and health.

13 Jan 2026

Dietary protein reshapes how cholera bacteria colonize the gut

Researchers investigate the role of dietary components and the gut microbiota in cholera.

13 Jan 2026

Discovery lays foundation for understanding how the cell senses membrane injuries

When the cell's recycling stations, the lysosomes, start leaking, it can become dangerous. Toxic waste risks spreading and damaging the cell.

12 Jan 2026

New publication describes the chemical journey of non-hormonal male birth control pill

A newly published manuscript authored by Dr. Gunda Georg, YourChoice Therapeutics and Columbia University Medical Center describes the chemical journey of YCT-529, a non-hormonal male birth control pill, and the promising molecular science behind it.

12 Jan 2026

Study identifies PUF60 as a critical vulnerability in triple negative breast cancer

Researchers at University of California San Diego have identified a previously unrecognized treatment target for triple‑negative breast cancer (TNBC), the most aggressive subtype of breast cancer.

12 Jan 2026

Two harmful gene variants can combine to restore normal protein function

In a groundbreaking study published in the in Proceedings of the National Academy of Sciences (PNAS), scientists at Pacific Northwest Research Institute (PNRI) have overturned a long-held belief in genetics: that inheriting two harmful variants in the same gene always worsens disease.

12 Jan 2026

Rare sugars activate metabolic signaling to reduce alcohol consumption in mice

While investigating the FGF21-oxytocin-dopamine system, a mechanism that regulates sugar appetite, a team of researchers at Kyoto University noticed reports suggesting that the protein FGF21 may regulate alcohol ingestion.

12 Jan 2026

Digital twin technology guides personalized treatment for brain cancer patients

A new machine-learning-based approach to mapping real-time tumor metabolism in brain cancer patients, developed at the University of Michigan, could help doctors discover which treatment strategies are most likely to be effective against individual cases of glioma.

12 Jan 2026