Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

People with cognitive impairment have altered responses to pain

People with dementia and other forms of cognitive impairment (CI) have altered responses to pain, with many conditions associated with increased pain sensitivity, concludes a research review in PAIN, the official publication of the International Association for the Study of Pain.

29 May 2015

Main culprit of Alzheimer's disease causes memory loss

The study, published May 29 in the open access Nature Publishing Group journal Scientific Reports, reveals a direct link between the main culprit of Alzheimer's disease and memory loss.

29 May 2015

RI-MUHC researchers receive $1.5 million to develop glutamate biosensor platform for brain diseases

In the human brain and retina, glutamate is an important messenger that carries information from one neuron to another. The level of glutamate transmitted between neurons is crucial to cell communication: too high and neurons die, too low and the information is not communicated properly. In either case this can contribute to neurological diseases including stroke, glaucoma, and Alzheimer's.

29 May 2015

People with MS have much greater risk of dying younger compared to people without MS

New research suggests people with multiple sclerosis (MS) may have double the risk of dying early compared to people without MS, with those younger than 59 at a three times higher risk. The study is published in the May 27, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

28 May 2015

Data supporting anti-cancer potential of Biscayne’s GHRH antagonist to be discussed at ASCO Annual Meeting

Biscayne Pharmaceuticals, Inc., today announced that data supporting the anti-cancer potential of its growth hormone-releasing hormone (GHRH) technology will be discussed in a poster presentation at the 2015 ASCO Annual Meeting.

28 May 2015

Diabetes and poor diet can trigger Alzheimer's or Parkinson's, warns BUAP researcher

For several years a researcher was dedicated to feed rodents in his laboratory with a high caloric content and glucose concentrations, which caused them diabetes, and by scientifically assessing what occurred in animals he observed that "diabetes and poor diet is a risk factor for developing Alzheimer's or Parkinson's," warns Samuel Treviño Mora from the Meritorious University of Puebla in Mexico.

28 May 2015

Six research teams awarded grant to accelerate discovery of new drugs for brain, nervous system disorders

CQDM, Brain Canada and the Ontario Brain Institute award close to $8.5M to six (6) multi-disciplinary and multi-provincial research teams across Canada to address unmet needs in neuroscience within their Focus on Brain strategic initiative. To this amount, $1.5M is added from the various research entities involved as in-kind contributions.

27 May 2015

UC San Diego Health System designated as Center of Excellence for Huntington's disease

The Huntington's Disease Clinical Research Center at UC San Diego Health System has been designated a Center of Excellence by the Huntington's Disease Society of America. UC San Diego was one of only 29 centers nationwide to receive this prestigious designation, which recognizes centers for their elite multidisciplinary approach to Huntington's disease care and research.

27 May 2015

New in vitro system could become important tool in search for potential drugs against Alzheimer’s

A typical characteristic of the brain of an Alzheimer sufferer is the presence of insoluble Tau protein aggregates. Scientists at VIB, KU Leuven and Janssen Pharmaceutica have demonstrated that the distribution of these aggregates through the brain is facilitated by synaptic connections between brain cells.

26 May 2015

Previous motherhood alters cognition, neuroplasticity in response to hormone therapy

Hormone therapy (HT) is prescribed to alleviate some of the symptoms of menopause in women. Menopausal women are more likely to be diagnosed with Alzheimer's disease but not other forms of dementia, and HT has been prescribed to treat cognitive decline in post-menopausal women with variable degrees of effectiveness.

26 May 2015

Mayo Clinic scientists create mouse model of ALS, FTD caused by mutations in C9ORF72 gene

Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both of which are caused by a mutation in the a gene called C9ORF72.

24 May 2015

Decreased removal of toxic peptides causes onset of Alzheimer's disease

Jens Pahnke and his team at the University of Oslo has recently published results in the prestigious scientific journal 'BRAIN' showing that decreased removal of toxic peptides in the brain causes the onset and first clinical signs of Alzheimer's disease, rather than overproduction as has previously been assumed. This information can now be used to target specific genes to enhance their function in the brain of elderly or people at risk.

22 May 2015

Studies refine amyloid imaging role in dementia

Two meta-analyses published in JAMA help to define the role of amyloid imaging in dementia.

21 May 2015

Certain proteins may slow cognitive decline in people with Alzheimer's disease

Certain proteins may slow the devastating memory loss caused by Alzheimer's disease, according to a groundbreaking Iowa State University study.

21 May 2015

Available research does not support link between chronic traumatic encephalopathy and sports

Available research does not support the contention that athletes are uniquely at risk of chronic traumatic encephalopathy (CTE) or other neurodegenerative disorders, according to a review in the June issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

21 May 2015

Omega-3 fatty acids improve cognitive flexibility in older adults at risk of late-onset Alzheimer's disease

A study of older adults at risk of late-onset Alzheimer's disease found that those who consumed more omega-3 fatty acids did better than their peers on tests of cognitive flexibility -- the ability to efficiently switch between tasks -- and had a bigger anterior cingulate cortex, a brain region known to contribute to cognitive flexibility.

20 May 2015

vTv Therapeutics enrolls first patients in azeliragon Phase 3 trial for treatment of mild Alzheimer's disease

vTv Therapeutics LLC today announced enrollment of the first patients into STEADFAST (Single Trial Evaluating Alzheimer's Disease Following Addition to Symptomatic Therapy), vTv's Phase 3 placebo controlled trial of azeliragon, an oral antagonist of the Receptor for Advanced Glycation Endproducts (RAGE) for treatment of mild Alzheimer's disease.

19 May 2015

Study: Air pollution, impaired lung function independently affect cognition

Studies have shown that both air pollution and impaired lung function can cause cognitive deficits, but it was unclear whether air pollution diminishes cognition by reducing breathing ability first or whether air pollution represents an independent risk factor for cognitive deficit.

19 May 2015

Grass plants can bind, uptake and transport infectious prions

Grass plants can bind, uptake and transport infectious prions, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).

18 May 2015

New findings could help better understand neurodegenerative diseases

Researchers at the Luxembourg Centre for Systems Biomedicine (LCSB), of the University of Luxembourg, have, under Dr. Manuel Buttini, successfully measured metabolic profiles, or the metabolomes, of different brain regions, and their findings could help better understand neurodegenerative diseases.

18 May 2015

Alzheimer's Disease News and Research

Further Reading

People with cognitive impairment have altered responses to pain

Main culprit of Alzheimer's disease causes memory loss

RI-MUHC researchers receive $1.5 million to develop glutamate biosensor platform for brain diseases

People with MS have much greater risk of dying younger compared to people without MS

Data supporting anti-cancer potential of Biscayne’s GHRH antagonist to be discussed at ASCO Annual Meeting

Diabetes and poor diet can trigger Alzheimer's or Parkinson's, warns BUAP researcher

Six research teams awarded grant to accelerate discovery of new drugs for brain, nervous system disorders

UC San Diego Health System designated as Center of Excellence for Huntington's disease

New in vitro system could become important tool in search for potential drugs against Alzheimer’s

Previous motherhood alters cognition, neuroplasticity in response to hormone therapy

Mayo Clinic scientists create mouse model of ALS, FTD caused by mutations in C9ORF72 gene

Decreased removal of toxic peptides causes onset of Alzheimer's disease

Studies refine amyloid imaging role in dementia

Certain proteins may slow cognitive decline in people with Alzheimer's disease

Available research does not support link between chronic traumatic encephalopathy and sports

Omega-3 fatty acids improve cognitive flexibility in older adults at risk of late-onset Alzheimer's disease

vTv Therapeutics enrolls first patients in azeliragon Phase 3 trial for treatment of mild Alzheimer's disease

Study: Air pollution, impaired lung function independently affect cognition

Grass plants can bind, uptake and transport infectious prions

New findings could help better understand neurodegenerative diseases

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