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Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

A new study indicates that the topoisomerase 1 (Top1) is intimately related to the lethal inflammation associated with SARS-CoV-2 infection in a large proportion of cases.

7 Dec 2020

Immunity passports may be valid based on how they are used, says UPV/EHU expert

According to the Chair in Law and the Human Genome at the University of the Basque Country (UPV/EHU), immunity passports may be valid, depending on how they are used.

6 Dec 2020

Study: CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial.

6 Dec 2020

Researchers recommend strategies for improving the accuracy of polygenic risk scores

As the consumer genetics industry rapidly expands, more and more people are turning to DNA-based services to learn their risk of developing a wide range of diseases.

5 Dec 2020

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Imagine swabbing your nostrils, putting the swab in a device, and getting a read-out on your phone in 15 to 30 minutes that tells you if you are infected with the COVID-19 virus.

5 Dec 2020

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease.

5 Dec 2020

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

A group of researchers developed a promising fix to CRISPR-Cas9's problem with unwanted genetic changes using a method that allows them to turn off gene-editing until it reaches key cell cycle phases where more accurate repairs are likely to happen.

4 Dec 2020

ATCC introduces new product segment with launch of SARS-CoV-2 external control kit

ATCC today announced the introduction of its new SARS-CoV-2 External Control Kit for clinical laboratories and test manufacturers.

From American Type Culture Collection (ATCC) 4 Dec 2020

Intermediate embryonic stem cell type could lead to advances in regenerative medicine

A team led by UT Southwestern has derived a new "intermediate" embryonic stem cell type from multiple species that can contribute to chimeras and create precursors to sperm and eggs in a culture dish.

4 Dec 2020

New CRISPR-Cas9 variant improves efficiency of gene editing tool

Using a new variant to repair DNA will improve both safety and effectiveness of the much-touted CRISPR-Cas9 tool in genetic research, Michigan Medicine researchers say.

3 Dec 2020

International scientific team reports 'super-spreader' potential of Andes virus

"Super-spreader" events and extensive person-to-person contact propelled an outbreak of hantavirus pulmonary syndrome in a small village in Argentina from 2018-2019, according to research published today in The New England Journal of Medicine.

3 Dec 2020

N-Glycosylation sites may contribute to spike-mediated invasion by SARS-CoV-2

The sugar residues decorating the spike (S) protein of SARS-CoV-2 are essential to the viral-receptor binding.

3 Dec 2020

Guidelines for accurate amplicon-based sequencing of SARS-CoV-2

A new study describes much-needed guidelines for reliable viral sequencing, validated in a large group of clinical samples.

3 Dec 2020

Scientists develop new bioinformatics pipeline to identify viruses in environmental samples

Researchers from the University of Helsinki have developed a novel bioinformatics pipeline called Lazy pipe for identifying viruses in host-associated or environmental samples.

3 Dec 2020

Novel “multitope” vaccine shows promise in the fight against COVID-19

Researchers have demonstrated the potential of a protein-peptide vaccine to protect against infection with SARS-CoV-2, the agent that causes COVID-19.

3 Dec 2020

SARS-CoV-2 D614G mutation does not affect performance of serological assays

In a new study published in The Journal of Infectious Diseases, US researchers considered the emergence of a new SARS-CoV-2 spike protein variant. They compared spike G614-based assay to the original D614-based assay – pointing towards the development of recognizable, cross-responsive humoral immunity.

2 Dec 2020

Spanish-originated SARS-CoV-2 variant A222V shows rapid spread in Lazio, Italy

A startling new study reports the rapid rise to dominance of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain in Italy. This strain, termed the GV clade, is characterized by a single point mutation.

2 Dec 2020

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

A team of researchers at the University of Tokyo in Japan have detected a sarbecovirus, called Rc-o319, which is phylogenetically positioned in the same clade as SARS-CoV-2 in Rhinolophus cornutus bats in Japan.

2 Dec 2020

Genethon to start international clinical trial for treatment of Duchenne muscular dystrophy

Genethon, dedicated to designing and developing gene therapy products for rare diseases, received this Monday 30th of November the authorization from the ANSM, the French National Agency for Medicines and Health Products Safety, to start in France a multicentre international clinical trial for the treatment of Duchenne muscular dystrophy with product GNT 004.

2 Dec 2020

Improved understanding of exposome-drug interactions could help prescribe effective drug doses

According to scientific estimations, humans are exposed to at least 10,000 to 100,000 environmental and exogenous compounds in an individual lifetime, which are mainly absorbed through our dietary.

2 Dec 2020

Genome News and Research

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

Immunity passports may be valid based on how they are used, says UPV/EHU expert

Study: CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

Researchers recommend strategies for improving the accuracy of polygenic risk scores

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

ATCC introduces new product segment with launch of SARS-CoV-2 external control kit

Intermediate embryonic stem cell type could lead to advances in regenerative medicine

New CRISPR-Cas9 variant improves efficiency of gene editing tool

International scientific team reports 'super-spreader' potential of Andes virus

N-Glycosylation sites may contribute to spike-mediated invasion by SARS-CoV-2

Guidelines for accurate amplicon-based sequencing of SARS-CoV-2

Scientists develop new bioinformatics pipeline to identify viruses in environmental samples

Novel “multitope” vaccine shows promise in the fight against COVID-19

SARS-CoV-2 D614G mutation does not affect performance of serological assays

Spanish-originated SARS-CoV-2 variant A222V shows rapid spread in Lazio, Italy

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

Genethon to start international clinical trial for treatment of Duchenne muscular dystrophy

Improved understanding of exposome-drug interactions could help prescribe effective drug doses

Genetics & Genomics - Second Edition eBook

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The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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