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Genetic inheritance and life experience leave distinct epigenetic marks in immune cells

The COVID-19 pandemic gave us tremendous perspective on how wildly symptoms and outcomes can vary between patients experiencing the same infection.

29 Jan 2026

Wake-promoting drug improves alertness in early morning shift workers

Many more people work very early morning shifts than overnight ones, and a large proportion struggle with excessive sleepiness from shift work disorder, leading to problems with focus, performance and safety.

29 Jan 2026

Eating beef as part of a healthy dietary pattern does not impact risk factors for type 2 diabetes

More than 135 million American adults are either living with or at risk for type 2 diabetes (T2D), elevating the need for more evidence-based dietary guidance to help this growing population achieve optimal health and reduce risks for T2D and its complications.

28 Jan 2026

First topical CRISPR gene therapy corrects disease-causing mutations in human skin

Gene-editing tools like CRISPR have unlocked new treatments for previously uncurable diseases. Now, researchers at the University of British Columbia are extending those possibilities to the skin for the first time.

27 Jan 2026

Antibody-producing plasma cells shape effectiveness of PD-1 immunotherapy

Scientists at the Icahn School of Medicine at Mount Sinai have identified an important immune response that helps explain why some cancer patients benefit from immunotherapy while others do not.

27 Jan 2026

UVA Data Science researcher leads $4.7M project for AI-powered diabetes management

University of Virginia School of Data Science researcher Heman Shakeri has been awarded a major new research grant to lead work at the intersection of machine learning and diabetes care.

27 Jan 2026

Multi-fluid microRNA signals as markers of endometriosis

Researchers uncover distinct microRNA profiles in bodily fluids, offering insights into noninvasive diagnostic markers for endometriosis and its complexities.

27 Jan 2026

JPM highlights | WuXi Biologics CEO Dr. Chris Chen: Scaled CRDMO platform delivering sustainable high growth

JPM Highlights | WuXi Biologics CEO Dr. Chris Chen: Scaled CRDMO Platform Delivering Sustainable High Growth

From WuXi Biologics 27 Jan 2026

New atlas of brain lysosomes sheds light on neurodegenerative disorders

Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when the cellular sanitation machines responsible for those tasks, called lysosomes, break down or get overwhelmed, it can increase the risk of Alzheimer's, Parkinson's, and other neurological disorders.

27 Jan 2026

Gene therapy targeting connexin 43 shows promise across inherited heart diseases

University of California San Diego-led team has discovered that restoring a key cardiac protein called connexin‑43 in a mouse model can dramatically improve heart function and extend survival in several inherited forms of arrhythmogenic cardiomyopathy (ACM)

26 Jan 2026

Microbiome differences distinguish preterm infants with parenteral nutrition-associated cholestasis

24 Jan 2026

WHO Member States advance negotiations on the Pathogen Access and Benefit‑Sharing system

The World Health Organization (WHO) Member States this week advanced their negotiations on the Pathogen Access and Benefit‑Sharing (PABS) system in a resumed session of the Intergovernmental Working Group (IGWG) on the WHO Pandemic Agreement.

24 Jan 2026

AI-designed NLRP3 inhibitor receives FDA clearance for Parkinson disease trials

Insilico Medicine (3696.HK), a clinical-stage drug discovery and development company driven by generative artificial intelligence (AI), today announced that ISM8969, an orally available NLRP3 inhibitor targeting inflammation and neurodegenerative disorders, has recently received investigational new drug (IND) clearance from the U.S. Food and Drug Administration (FDA), intended for the treatment of Parkinson's Disease.

23 Jan 2026

Trojan horse immunotherapy opens tumors to immune system attack

Scientists at the Icahn School of Medicine at Mount Sinai have developed an experimental immunotherapy that takes an unconventional approach to metastatic cancer: instead of going after cancer cells directly, it targets the cells that protect them.

22 Jan 2026

Cancer vaccines enter a new era of personalized immunotherapy

A new comprehensive review from researchers at the Icahn School of Medicine at Mount Sinai details how decades of cancer vaccine research are converging into a new era of more precise, personalized, and effective immunotherapies, particularly when combined with other cancer treatments.

22 Jan 2026

Targeted uterine mRNA treatment boosts fertility outcomes in mice

Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine - which designs nanotechnology-based platforms for clinical translation across specialties - developed a strategy for delivering therapeutic messenger RNA (mRNA) to the inner lining of the uterus (endometrium) in mice via modified lipid nanoparticles (LNPs), which are small capsules made of fatty molecules.

22 Jan 2026

Large study identifies more than 100 genetic regions linked to schizophrenia

A team of researchers led by scientists from the Icahn School of Medicine at Mount Sinai, SUNY Downstate Health Sciences University, and the Department of Veterans Affairs has conducted the largest and most comprehensive genome-wide association study (GWAS) to date of schizophrenia in individuals of African ancestry.

21 Jan 2026

High-dose inhaled nitric oxide could fight multidrug-resistant infections

Overuse of antibiotics has accelerated the development of bacterial resistance to conventional drugs, a global health crisis projected to result in more than 10 million deaths annually by 2050.

21 Jan 2026

Study shows DHPS enzyme controls macrophage maturation across multiple organs

A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health found that an enzyme involved in protein translation is essential for circulating immune cells, called monocytes, to mature into tissue-resident macrophages, a specialized population of immune cells that maintain organ health by clearing dead cells and debris.

21 Jan 2026

Lifestyle prevention of diabetes may halve carbon footprint associated with treating complications

Preventing high blood glucose (pre-diabetes) from turning into type 2 diabetes with lifestyle changes could more than halve the carbon footprint associated with treating the complications of the disease, suggests a modelling study, published in the open access journal BMJ Open.

20 Jan 2026

Therapeutics News and Research

Genetic inheritance and life experience leave distinct epigenetic marks in immune cells

Wake-promoting drug improves alertness in early morning shift workers

Eating beef as part of a healthy dietary pattern does not impact risk factors for type 2 diabetes

First topical CRISPR gene therapy corrects disease-causing mutations in human skin

Antibody-producing plasma cells shape effectiveness of PD-1 immunotherapy

UVA Data Science researcher leads $4.7M project for AI-powered diabetes management

Multi-fluid microRNA signals as markers of endometriosis

JPM highlights | WuXi Biologics CEO Dr. Chris Chen: Scaled CRDMO platform delivering sustainable high growth

New atlas of brain lysosomes sheds light on neurodegenerative disorders

Gene therapy targeting connexin 43 shows promise across inherited heart diseases

Microbiome differences distinguish preterm infants with parenteral nutrition-associated cholestasis

WHO Member States advance negotiations on the Pathogen Access and Benefit‑Sharing system

AI-designed NLRP3 inhibitor receives FDA clearance for Parkinson disease trials

Trojan horse immunotherapy opens tumors to immune system attack

Cancer vaccines enter a new era of personalized immunotherapy

Targeted uterine mRNA treatment boosts fertility outcomes in mice

Large study identifies more than 100 genetic regions linked to schizophrenia

High-dose inhaled nitric oxide could fight multidrug-resistant infections

Study shows DHPS enzyme controls macrophage maturation across multiple organs

Lifestyle prevention of diabetes may halve carbon footprint associated with treating complications

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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