Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

'Mad Cow' discovery points to possible neuron killing mechanism behind alzheimer’s and parkinson’s diseases

The new study, published recently in the journal Brain, revealed the mechanism of toxicity of a misfolded form of the protein that underlies prion diseases, such as bovine spongiform encephalopathy (“mad cow disease”) and its human equivalent, Creutzfeldt-Jakob disease.

13 Feb 2015

Stem cell transplants more effective than mitoxantrone drug for people with severe multiple sclerosis

Stem cell transplants may be more effective than the drug mitoxantrone for people with severe cases of multiple sclerosis (MS), according to a new study published in the February 11, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

12 Feb 2015

RAB3GAP complex plays important role in autophagy

Neurodegenerative disorders such as Alzheimer's disease are typically characterized by protein deposits in the brain. These are comprised of defective, insoluble proteins which no longer fulfill their function and which cells are unable to break down. The work group headed by Professor Christian Behl of the Institute of Pathobiochemistry of the University Medical Center of Johannes Gutenberg University Mainz has determined the RAB3GAP complex as a novel factor that influences the efficient degradation of proteins.

12 Feb 2015

Children exposed to air pollution are at increased risk for brain inflammation, neurodegenerative changes

City smog lowers children's IQ. This is among findings from a recent University of Montana study that found children living in cities with significant air pollution are at an increased risk for detrimental impacts to the brain, including short-term memory loss and lower IQ.

12 Feb 2015

Transition Therapeutics commences underwritten public offering of common shares

Transition Therapeutics Inc. announced today that it has commenced an underwritten public offering of its common shares.

12 Feb 2015

New article assesses 40 years of intensive effort to improve end-of-life care

After four decades of work - first on patients' rights, then on family and caregiving relationships, and most recently on systemic reform -- we now know that it will take additional efforts in all three areas to improve care at the end of life, concludes an article in the New England Journal of Medicine.

11 Feb 2015

ADDF, Pfizer's CTI collaborate to advance development of new drugs for Alzheimer's disease

The Alzheimer's Drug Discovery Foundation and Pfizer's Centers for Therapeutic Innovation announced today a collaboration designed to advance the development of new small-molecule drugs for Alzheimer's disease and related dementias. As part of the first-of-its kind collaboration in Alzheimer's, the ADDF and CTI will jointly invest in translational research projects, with a focus on novel Alzheimer's drug targets.

11 Feb 2015

Movement Disorder Center at UC San Diego designated Center of Excellence in NPF's global network

The Movement Disorder Center at UC San Diego Health System has been designated the 41st Center of Excellence in the National Parkinson Foundation's global network. This competitive designation is the highest recognition offered by NPF to a Parkinson's specialty clinic and represents the consensus of leaders in the field that the multidisciplinary clinic at UC San Diego Health System is among the world's leading centers for Parkinson's research, outreach and care.

11 Feb 2015

Kessler Institute for Rehabilitation offers tips to help caregivers cope with challenges

Husbands and wives, parents and children, siblings and others are taking on the role of caregiver for family members who are unable to care for themselves due to disabilities, chronic health conditions or the challenges related to aging. In fact, more than 90 million caregivers – two out of five adults – are now providing that daily care, an increase of 30% since 2010.

11 Feb 2015

Three leading research funders join forces to support brain disease research

Three leading research funders from the UK and North America have joined forces to launch a new global initiative called MEND or, MEchanisms of cellular death in NeuroDegeneration, with a fund of $1.25 million USD (£820,000/$1.56CDN) for targeted research into brain diseases that cause dementia, such as Alzheimer's.

11 Feb 2015

UB neurologist examines neurological disorders of U.S. presidents

Neurology and history may sound like two fields that don't often overlap, but they have, sometimes with extraordinary consequences, according to a University at Buffalo neurologist.

10 Feb 2015

New study heightens concerns over the detrimental impact of APOE ε4 in urban children

A new study by researchers at the Universities of Montana, Carleton, and North Carolina, and the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, heightens concerns over the detrimental impact of the apolipoprotein E (APOE) ε4 allele -- the most prevalent genetic risk for Alzheimer's disease -- upon cognition, olfaction, and metabolic brain indices in healthy urban children and teens.

9 Feb 2015

UVA researchers find biological trigger for protective form of immune response to spinal cord injury

Hot on the heels of discovering a protective form of immune response to spinal cord injury, researchers at the University of Virginia School of Medicine have pinpointed the biological trigger for that response - a vital step toward being able to harness the body's defenses to improve treatment for spine injuries, brain trauma, Alzheimer's disease and other neurodegenerative conditions.

8 Feb 2015

New study shows that the body's immune system may be able to clear Alzheimer's-associated plaques

New research from scientists at the Keck School of Medicine of the University of Southern California shows that the body's immune system may be able to clear the brain of toxic plaque build-up that is the hallmark of Alzheimer's disease, reversing memory loss and brain cell damage.

6 Feb 2015

Research findings could lead to improved treatments for brain and spinal cord injuries

6 Feb 2015

Alzheimer's brains commonly have many neurons with more DNA and genomic copies of APP gene

Scientists at The Scripps Research Institute have found diverse genomic changes in single neurons from the brains of Alzheimer's patients, pointing to an unexpected factor that may underpin the most common form of the disease.

5 Feb 2015

Resveratrol found in red grapes, peanuts may help prevent age-related decline in memory

A compound found in common foods such as red grapes and peanuts may help prevent age-related decline in memory, according to new research published by a faculty member in the Texas A&M Health Science Center College of Medicine.

5 Feb 2015

Hockey legend diagnosed with suspected Lewy body dementia

The sad news of hockey legend Stan Mikita's illness has brought unexpected visibility to a disease unfamiliar to many people.

4 Feb 2015

FDA accepts Sangamo BioSciences' IND for SB-BCLmR-HSPC genome editing approach

Sangamo BioSciences, Inc. announced today that an Investigational New Drug (IND) application for the company's SB-BCLmR-HSPC genome editing approach, which is designed to provide a one-time lasting therapy for beta-thalassemia, has been accepted by the U.S. Food and Drug Administration and is now active.

4 Feb 2015

SuperAgers have distinctly different looking brains

SuperAgers, aged 80 and above, have distinctly different looking brains than those of normal older people, according to new Northwestern Medicine research that is beginning to reveal why the memories of these cognitively elite elders don't suffer the usual ravages of time.

4 Feb 2015

Alzheimer's Disease News and Research

Further Reading

'Mad Cow' discovery points to possible neuron killing mechanism behind alzheimer’s and parkinson’s diseases

Stem cell transplants more effective than mitoxantrone drug for people with severe multiple sclerosis

RAB3GAP complex plays important role in autophagy

Children exposed to air pollution are at increased risk for brain inflammation, neurodegenerative changes

Transition Therapeutics commences underwritten public offering of common shares

New article assesses 40 years of intensive effort to improve end-of-life care

ADDF, Pfizer's CTI collaborate to advance development of new drugs for Alzheimer's disease

Movement Disorder Center at UC San Diego designated Center of Excellence in NPF's global network

Kessler Institute for Rehabilitation offers tips to help caregivers cope with challenges

Three leading research funders join forces to support brain disease research

UB neurologist examines neurological disorders of U.S. presidents

New study heightens concerns over the detrimental impact of APOE ε4 in urban children

UVA researchers find biological trigger for protective form of immune response to spinal cord injury

New study shows that the body's immune system may be able to clear Alzheimer's-associated plaques

Research findings could lead to improved treatments for brain and spinal cord injuries

Alzheimer's brains commonly have many neurons with more DNA and genomic copies of APP gene

Resveratrol found in red grapes, peanuts may help prevent age-related decline in memory

Hockey legend diagnosed with suspected Lewy body dementia

FDA accepts Sangamo BioSciences' IND for SB-BCLmR-HSPC genome editing approach

SuperAgers have distinctly different looking brains

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