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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

The intranasal route of immunization may offer effective protection against SARS-CoV-2

Researchers at the School of Medicine, Washington University in Saint Louis, USA, showed that the intranasal route of immunization could provide a more efficient protection against SARS-CoV-2 compared to the intramuscular route (i.e. through ‘jabs’).

7 Dec 2020

Potential SARS-CoV-2 Mpro inhibitors identified by in silico screening

The search for effective inhibitors of SARS-CoV-2 is assuming new urgency as the fall/winter resurgence of the infection appears.

7 Dec 2020

COVID-19 genetic risk variants impact diverse immune cell types and severe disease manifestations

A team of researchers from UK and US used the DICE database and 3D cis-interactome maps to generate a list of target genes and immune cell types that are most affected by the genetic variants associated with COVID-19 severity.

7 Dec 2020

Molecular simulations reveal that remdesivir targets two SARS-CoV-2 enzymes

Remdesivir has been shown to target both RNA-dependent RNA polymerase and main protease of SARS-CoV-2 – resulting in a ‘double whammy’ effect.

7 Dec 2020

Evolution of the SARS-CoV-2 proteome in 3D during the first six months of the COVID-19 pandemic

In a recent study, researchers report how the SARS-CoV-2 proteome in 3D has evolved during the first six months of the COVID-19 pandemic.

7 Dec 2020

Study identifies multiple important genomic differences in BCL malignancies using genomic ancestry

B-cell lymphoma and leukemias (BCL) are a diverse set of malignancies. While the genomic landscape of many BCL subtypes has been described, genomic ancestry has rarely been explored.

6 Dec 2020

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Imagine swabbing your nostrils, putting the swab in a device, and getting a read-out on your phone in 15 to 30 minutes that tells you if you are infected with the COVID-19 virus.

5 Dec 2020

Lung tissue analysis reveals promising molecular target to ameliorate pulmonary fibrosis

An analysis of lung tissues from patients with different types of pulmonary fibrosis - including cases triggered by COVID-19 - has revealed a promising molecular target to ameliorate the chronic and irreversible disease.

5 Dec 2020

COVID-19 pandemic has led to a decrease in hospital-wide HCV testing

New research from Boston Medical Center finds that the COVID-19 emergency systemic changes made to decrease in-person visits during the pandemic have led to a decrease in hospital-wide Hepatitis C (HCV) testing by 50 percent, and a reduction in new HCV diagnoses by more than 60 percent.

4 Dec 2020

COVID-19 single-shot segmentation for chest CT-based diagnosis

A new study from an artificial intelligence (AI) scientist describes a method to predict COVID-19 from a single chest CT shot.

4 Dec 2020

New antiviral drug completely suppresses SARS-CoV-2 transmission within 24 hours

Treatment of SARS-CoV-2 infection with a new antiviral drug, MK-4482/EIDD-2801 or Molnupiravir, completely suppresses virus transmission within 24 hours, researchers in the Institute for Biomedical Sciences at Georgia State University have discovered.

3 Dec 2020

High seroprevalence of short-lived anti-SARS-CoV-2 antibodies in Paris

A recent study indicates a high seroprevalence of antibodies against SARS-CoV-2 among individuals working in a Paris-based institute.

3 Dec 2020

Guidelines for accurate amplicon-based sequencing of SARS-CoV-2

A new study describes much-needed guidelines for reliable viral sequencing, validated in a large group of clinical samples.

3 Dec 2020

Scientists develop new bioinformatics pipeline to identify viruses in environmental samples

Researchers from the University of Helsinki have developed a novel bioinformatics pipeline called Lazy pipe for identifying viruses in host-associated or environmental samples.

3 Dec 2020

SARS-CoV-2 enters the CNS via multiple routes and causes various neurological disorders

The COVID-19 pandemic has led to millions of deaths across the globe. The causative agent of this disease is the novel coronavirus, SARS-CoV-2.

3 Dec 2020

Novel “multitope” vaccine shows promise in the fight against COVID-19

Researchers have demonstrated the potential of a protein-peptide vaccine to protect against infection with SARS-CoV-2, the agent that causes COVID-19.

3 Dec 2020

New insight into role of autophagy in controlling SARS-CoV-2 infection

A team of researchers at the University of Manitoba in Canada said that nanoparticle targeting of autophagy at the sites could be a potent tool to effectively overcome COVID-19 while preventing the common adverse effects of the drug.

2 Dec 2020

The UK approves Pfizer vaccine for December 2020 roll out

The UK approves Pfizer vaccine and schedules phased vaccination process, commencing December 2020.

2 Dec 2020

A new potential COVID-19 vaccine candidate: YF-S0

A recent study published in the journal Nature describes the safety and efficacy of a live-attenuated yellow fever 17D (YF17D) vector-based vaccine candidate expressing a non-cleavable form of the spike protein of severe acute respiratory coronavirus 2 (SARS-CoV2).

2 Dec 2020

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

A team of researchers at the University of Tokyo in Japan have detected a sarbecovirus, called Rc-o319, which is phylogenetically positioned in the same clade as SARS-CoV-2 in Rhinolophus cornutus bats in Japan.

2 Dec 2020

RNA News and Research

Further Reading

The intranasal route of immunization may offer effective protection against SARS-CoV-2

Potential SARS-CoV-2 Mpro inhibitors identified by in silico screening

COVID-19 genetic risk variants impact diverse immune cell types and severe disease manifestations

Molecular simulations reveal that remdesivir targets two SARS-CoV-2 enzymes

Evolution of the SARS-CoV-2 proteome in 3D during the first six months of the COVID-19 pandemic

Study identifies multiple important genomic differences in BCL malignancies using genomic ancestry

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Lung tissue analysis reveals promising molecular target to ameliorate pulmonary fibrosis

COVID-19 pandemic has led to a decrease in hospital-wide HCV testing

COVID-19 single-shot segmentation for chest CT-based diagnosis

New antiviral drug completely suppresses SARS-CoV-2 transmission within 24 hours

High seroprevalence of short-lived anti-SARS-CoV-2 antibodies in Paris

Guidelines for accurate amplicon-based sequencing of SARS-CoV-2

Scientists develop new bioinformatics pipeline to identify viruses in environmental samples

SARS-CoV-2 enters the CNS via multiple routes and causes various neurological disorders

Novel “multitope” vaccine shows promise in the fight against COVID-19

New insight into role of autophagy in controlling SARS-CoV-2 infection

The UK approves Pfizer vaccine for December 2020 roll out

A new potential COVID-19 vaccine candidate: YF-S0

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

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