Nucleic Acid News and Research

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World Health Organization issues notice for in vitro diagnostics users

Nucleic acid testing (NAT) technologies that use real-time polymerase chain reaction (RT-PCR) for detection of SARS-CoV-2.

14 Dec 2020

Research shows how epithelial cells ward off viruses

A team led by Ludwig-Maximilians-Universitaet in Munich Researcher Veit Hornung has shown that a protein found in skin cells recognizes a specific nucleic acid intermediate that is formed during virus replication. This recognition process subsequently induces a potent inflammatory response.

11 Dec 2020

Rapid lateral flow immunoassay enables fluorescence detection of SARS-Cov-2 RNA

The COVID-19 pandemic has highlighted the need for rapid and accurate nucleic acid detection at the point of care. To meet this need, scientists from the Suzhou Institute of Biomedical Engineering and Technology have developed a novel amplification-free rapid SARS-CoV-2 nucleic acid detection platform based on hybrid capture fluorescence immunoassay (HC-FIA).

11 Dec 2020

MEDS433 hinders SARS-CoV-2 replication

A paper that recently appeared in the preprint server bioRxiv* reports the powerful activity of a compound named MEDS433 against this virus.

10 Dec 2020

Paper-based electrochemical sensor can enable rapid detection of SARS-CoV-2

As the COVID-19 pandemic continues to spread across the world, testing remains a key strategy for tracking and containing the virus.

7 Dec 2020

Novel modular design approach to antibody nanocage generation

A new study shows the benefits of using computational design to create antibody nanocages that have the required orientation.

7 Dec 2020

Advances in Microplate Technology at SLAS 2021

Porvair Sciences will exhibit its latest specialist microplates and microplate instrumentation at the forthcoming SLAS 2021 Digital International Conference and Exhibition (January 25-27th 2021).

From Porvair Sciences Limited 3 Dec 2020

Chinese woman still sheds SARS-CoV-2 over four months post-infection

A new study by Chinese scientists explore an unusual case of extended viral shedding in a 68-year-old woman up to four months post-infection.

1 Dec 2020

Nucleic acid-hydrolyzing scFv 3D8 exhibits potent antiviral effects on SARS-CoV-2

3D8, a 27-kDa recombinant antibody fragment, was found in autoimmune-prone Murphy Roths Large mice. The single-chain variable fragment (scFv) has the nucleic acid hydrolyzing activity and is shown to degrade DNA or mRNA of viruses in infected cells.

30 Nov 2020

HIV and TB laboratory systems used to scale up COVID-19 testing in Africa

Many countries in resource-limited settings have high HIV, malaria, tuberculosis, hepatitis, and/or sexually transmitted infection (STI) burdens.

30 Nov 2020

Wuhan mass screening program finds 300 asymptomatic cases

A mass screening programme of more than 10 million Wuhan residents identified 300 asymptomatic cases, but none were infectious - according to a study involving the University of East Anglia.

30 Nov 2020

$Multiple fractionation approach for measuring cancer biomarker enrichment in exosomes$

Multiple fractionation approach for measuring cancer biomarker enrichment in exosomes

Postnova Analytics reports that researchers from the University of Utah have used a novel combination of Asymmetrical Flow Field-Flow Fractionation and Centrifugal Field-Flow Fractionation to measure cancer biomarker enrichment in exosomes.

From Postnova Analytics 27 Nov 2020

Computational model can help predict cellular drug targets against COVID-19

A computational model of a human lung cell has been used to understand how SARS-CoV-2 draws on human host cell metabolism to reproduce by researchers at the University of Warwick.

25 Nov 2020

Digital warm-start CRISPR assay enables sensitive quantitative detection of SARS-CoV-2 in clinical samples

In a recent medRxiv* preprint paper, researchers from the University of Connecticut Health Center in the United States unveil their digital warm-start CRISPR (WS-CRISPR) method for stringent and sensitive quantitative detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples of patients with coronavirus disease (COVID-19).

24 Nov 2020

Measurement of Cancer Biomarker Enrichment in Exosomes

Postnova Analytics reports that researchers from the University of Utah (Salt Lake City, USA) have used a novel combination of Asymmetrical Flow Field-Flow Fractionation and Centrifugal Field-Flow Fractionation to measure cancer biomarker enrichment in exosomes.

From Postnova Analytics 24 Nov 2020

Greensboro North Carolina Company’s Dedication to Ensuring Laboratories have COVID-19 Supplies Now Offers One-Stop-Shop for PCR Instruments, Extraction Systems and Kits, POC COVID-19 Test Kits, and Supplies.

GREENSBORO, NC — (November 20, 2020) – Greensboro-based, Carolina Liquid Chemistries Corp. (CLC) has been tirelessly working since the beginning of the COVID-19 outbreak to provide high-quality testing kits and instruments to healthcare providers and laboratories as quickly as possible.

From Carolina Liquid Chemistries Corp. 23 Nov 2020

Chicago seroprevalence study shows COVID-19 cases 16 times higher than currently predicted

A startling new case study of Chicago, led by a team of researchers at Northwestern University in Illinois, USA, suggests a 16-fold higher incidence of SARS-CoV-2 infection than previously thought. This is judging from seroprevalence (antibody presence blood testing) figures, rather than the number of RT-PCR-positives reported there (via swab sample testing of symptomatic patients).

23 Nov 2020

New multiplex assay can be used for epidemiological surveillance, management of COVID-19

Scientists from Northwell Health Laboratories have developed a new diagnostic multiplex assay that can be used for epidemiological surveillance and clinical management of COVID-19.

17 Nov 2020

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

The hunt for antivirals has reached an unprecedented pace in light of the coronavirus 2019 (COVID-19) pandemic. The causal agent for this disease – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – has already infected over 52 million people worldwide, and has subsequently claimed over 1.3 million lives. However, among the innumerable promising drug candidates that help battle the virus and mitigate its damage, none have yet made it to the clinic.

12 Nov 2020

Spike-based DNA vaccine shows excellent protection against SARS-CoV-2 in a hamster model

A study conducted at the United States Army Research Institute of Infectious Diseases shows how a relatively simple full-length DNA vaccine against spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit neutralizing antibody response in an animal model – even after a single shot with simple jet injection technique.

11 Nov 2020

Nucleic Acid News and Research

World Health Organization issues notice for in vitro diagnostics users

Research shows how epithelial cells ward off viruses

Rapid lateral flow immunoassay enables fluorescence detection of SARS-Cov-2 RNA

MEDS433 hinders SARS-CoV-2 replication

Paper-based electrochemical sensor can enable rapid detection of SARS-CoV-2

Novel modular design approach to antibody nanocage generation

Advances in Microplate Technology at SLAS 2021

Chinese woman still sheds SARS-CoV-2 over four months post-infection

Nucleic acid-hydrolyzing scFv 3D8 exhibits potent antiviral effects on SARS-CoV-2

HIV and TB laboratory systems used to scale up COVID-19 testing in Africa

Wuhan mass screening program finds 300 asymptomatic cases

Multiple fractionation approach for measuring cancer biomarker enrichment in exosomes

Computational model can help predict cellular drug targets against COVID-19

Digital warm-start CRISPR assay enables sensitive quantitative detection of SARS-CoV-2 in clinical samples

Measurement of Cancer Biomarker Enrichment in Exosomes

Greensboro North Carolina Company’s Dedication to Ensuring Laboratories have COVID-19 Supplies Now Offers One-Stop-Shop for PCR Instruments, Extraction Systems and Kits, POC COVID-19 Test Kits, and Supplies.

Chicago seroprevalence study shows COVID-19 cases 16 times higher than currently predicted

New multiplex assay can be used for epidemiological surveillance, management of COVID-19

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

Spike-based DNA vaccine shows excellent protection against SARS-CoV-2 in a hamster model

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Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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