Therapeutics News and Research

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FDA grants Orphan Drug Designation to Myelo001 for treatment of Acute Radiation Syndrome

Myelo Therapeutics GmbH announced today that the US Food and Drug Administration has granted an Orphan Drug Designation to its orally applied new chemical entity Myelo001 for the treatment of Acute Radiation Syndrome.

25 Sep 2018

Cerevance starts dosing in Phase I clinical trial of CVN424 for treatment of Parkinson's disease

Cerevance, a clinical-stage drug discovery and development company focused on brain diseases, today announced the start of dosing in a Phase I first-in-human clinical trial of CVN424, an oral compound being developed for symptomatic treatment of Parkinson's disease.

25 Sep 2018

NIRS-IVUS imaging identifies patients and plaques vulnerable to subsequent adverse cardiac events

Results from the Lipid-Rich Plaque study demonstrate the correlation between the presence of non-flow-limiting, non-intervened upon, lipid-rich plaques detected by NIRS-IVUS imaging and the development of a major adverse cardiac event from a de novo culprit lesion at both the patient level (vulnerable patients) and segment level (vulnerable plaques) within 24 months post intravascular imaging.

25 Sep 2018

Special Focus Issue takes wide view of complementary and integrative medicine in cancer

A Special Focus Issue on Integrative Oncology takes a wide-ranging view of the possible approaches and potential therapeutic benefits of complementary and integrative medicine in multiple age groups, nations, and special populations.

25 Sep 2018

Clinical study shows efficacy, safety of novel drug-eluting stent with improved radiographic visibility

This first randomized clinical study of a polymer-coated zotarolimus-eluting stent (Resolute Onyx) that utilizes a novel thin-strutted metallic platform allowing for better x-ray visibility was shown to be non-inferior to an ultrathin-strutted bioresorbable polymer-coated sirolimus-eluting stent (Orsiro) that uses a cobalt-chromium strut platform.

25 Sep 2018

Gene therapy approach could help treat mitochondrial diseases

Researchers have developed a genome-editing tool for the potential treatment of mitochondrial diseases: serious and often fatal conditions which affect 1 in 5,000 people.

24 Sep 2018

Ancora Heart announces positive data of study evaluating AccuCinch Ventricular Repair System

Ancora Heart, Inc., a company developing a novel therapy to address heart failure, today announced positive clinical data from the company's recently expanded U.S. early feasibility study evaluating the safety of the investigational AccuCinch Ventricular Repair System designed for the treatment of heart failure and functional mitral regurgitation.

24 Sep 2018

Gilead Sciences plans to launch authorized generic versions of Epclusa and Harvoni in the US

Gilead Sciences, Inc. announced today plans to launch authorized generic versions of Epclusa and Harvoni, Gilead's leading treatments for chronic hepatitis C virus, in the United States, through a newly created subsidiary, Asegua Therapeutics LLC.

24 Sep 2018

Lumos acquires license for LUM-201 drug that promotes secretion of growth hormone

Lumos Pharma, Inc., a clinical stage biopharmaceutical company focused on development and commercialization of therapeutics for rare and neglected diseases, today announced that it has acquired the license for LUM-201, an investigational orally administered small molecule that promotes secretion of growth hormone from the pituitary gland, from Ammonett Pharma LLC.

24 Sep 2018

Study: Transcatheter mitral valve repair reduces mortality for patients with mitral regurgitation

A multicenter clinical trial has found that a minimally invasive procedure called transcatheter mitral valve repair significantly reduced hospitalizations and mortality for heart failure patients with moderate-to-severe or severe functional mitral regurgitation.

24 Sep 2018

Most patients who underwent transcatheter valve replacement experience prosthesis-patient mismatch

In the largest multi-institutional study to date, led by researchers from Penn Medicine, the team found that among patients who underwent a transcatheter aortic valve replacement, a high number experienced severe and moderate cases of prosthesis-patient mismatch--meaning the implanted heart valve is too small for the patient which can lead to inadequate blood flow.

24 Sep 2018

New research suggests power of zebrafish as tool for cancer drug discovery

The lab of Leonard Zon, MD, at Boston Children's Hospital has long been interested in making blood stem cells in quantity for therapeutic purposes.

24 Sep 2018

Transcatheter mitral-valve repair in patients with heart failure

A new heart device called the MitraClip (from Abbott) has been shown to benefit patients with heart failure and reduce death rates among them significantly.

23 Sep 2018

USC research uncovers previously unknown genetic risk factor for dementia

New research from USC has uncovered a previously unknown genetic risk factor for Alzheimer's disease and related dementias. The study provides insights on how these conditions, and other diseases of aging, might one day be treated and prevented.

21 Sep 2018

Dopamine neurons may involve in conditions ranging from Parkinson's disease to schizophrenia

Dopamine neurons are located in the midbrain, but their tendril-like axons can branch far into the higher cortical areas, influencing how we move and how we feel.

21 Sep 2018

Sesen Bio to present its three-month Phase 3 VISTA Trial data at Global Congress

Sesen Bio, Inc., a late-stage clinical company developing fusion protein therapies for the treatment of cancer, today announced that the company will present its three-month Phase 3 VISTA Trial data during a poster session at the Global Congress on Bladder Cancer 2018.

20 Sep 2018

LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines

Applied DNA Sciences Inc. announced today that LineaRx, Inc., its wholly-owned subsidiary focused on next-generation biotherapeutics, has signed a Joint Development Agreement with Takis S.R.L. and Evvivax S.R.L., biotechnology companies focused on the discovery and development of DNA based anti-cancer vaccines for the human and animal markets, respectively.

20 Sep 2018

ALSAM Foundation invests additional $2 million for drug discovery and development projects

The ALSAM Foundation recently invested an additional $2 million to continue the Therapeutic Innovation Grants Program at the CU Skaggs School of Pharmacy and Pharmaceutical Sciences.

20 Sep 2018

Celltrion and Emory University sign 'Incubation' agreement to develop new drug candidates for atherosclerosis

Celltrion, Inc. signed an 'Incubation' agreement with Emory University in Atlanta to support the research and development of new drug candidates for atherosclerosis.

20 Sep 2018

Geroscience takes center stage in Journal of the American Medical Association

Geroscience--the burgeoning research field that focuses on the genetic, molecular, and cellular mechanisms that make aging a major risk factor for most chronic diseases as we age--takes center stage in the Journal of the American Medical Association, the world's most widely circulated medical journal.

20 Sep 2018

Therapeutics News and Research

FDA grants Orphan Drug Designation to Myelo001 for treatment of Acute Radiation Syndrome

Cerevance starts dosing in Phase I clinical trial of CVN424 for treatment of Parkinson's disease

NIRS-IVUS imaging identifies patients and plaques vulnerable to subsequent adverse cardiac events

Special Focus Issue takes wide view of complementary and integrative medicine in cancer

Clinical study shows efficacy, safety of novel drug-eluting stent with improved radiographic visibility

Gene therapy approach could help treat mitochondrial diseases

Ancora Heart announces positive data of study evaluating AccuCinch Ventricular Repair System

Gilead Sciences plans to launch authorized generic versions of Epclusa and Harvoni in the US

Lumos acquires license for LUM-201 drug that promotes secretion of growth hormone

Study: Transcatheter mitral valve repair reduces mortality for patients with mitral regurgitation

Most patients who underwent transcatheter valve replacement experience prosthesis-patient mismatch

New research suggests power of zebrafish as tool for cancer drug discovery

Transcatheter mitral-valve repair in patients with heart failure

USC research uncovers previously unknown genetic risk factor for dementia

Dopamine neurons may involve in conditions ranging from Parkinson's disease to schizophrenia

Sesen Bio to present its three-month Phase 3 VISTA Trial data at Global Congress

LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines

ALSAM Foundation invests additional $2 million for drug discovery and development projects

Celltrion and Emory University sign 'Incubation' agreement to develop new drug candidates for atherosclerosis

Geroscience takes center stage in Journal of the American Medical Association

Industry Focus eBook - Microbiome (1st edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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