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New method enables comprehensive analysis of metabolites in biological samples

Researchers from the McCullagh Group in Oxford University's Department of Chemistry have published an innovative method in Nature Protocols today (22 August) that provides comprehensive analysis of metabolites found in cells, tissues and biofluids.

22 Aug 2025

Hypothalamic neurons help maintain blood sugar during daily activities

The brain controls the release of glucose in a wide range of stressful circumstances, including fasting and low blood sugar levels.

21 Aug 2025

Edible microbeads trap fat to support weight loss

Weight-loss interventions, including gastric bypass surgery and drugs that prevent dietary fat absorption, can be invasive or have negative side effects.

21 Aug 2025

How dietary formaldehyde links to worsening diabetes and memory loss

A new review reveals how everyday foods and hidden exposures to formaldehyde may fuel insulin resistance and chip away at memory, but also points to dietary patterns and emerging therapies that could help reduce the risk.

20 Aug 2025

Fish oil supplementation can reduce risk of developing type 2 diabetes in prediabetic individuals

Type 2 diabetes (T2D) has become one of the leading chronic diseases worldwide in terms of both incidence and mortality.

20 Aug 2025

Low FODMAP diet increases GLP-1 and relieves IBS symptoms

This study reveals that a low FODMAP diet alleviates IBS symptoms and increases GLP-1 levels, suggesting new avenues for dietary interventions in gut health.

20 Aug 2025

Fasting supports type 1 diabetes care by reshaping the microbiome

A week of fasting alters the gut microbiome in type 1 diabetes, aligning it with healthy profiles and enhancing cholesterol and weight management.

20 Aug 2025

Could chlorophyll become the next antidiabetic therapy?

Research highlights chlorophyll's role in blood sugar regulation and insulin mimicry, though safety risks and lack of human trials warrant caution.

20 Aug 2025

Review finds coffee linked to longer life and lower disease risk

A new review highlights that coffee consumption is consistently linked to reduced risks of death, cardiovascular disease, diabetes, and some cancers, while also supporting mental and physical well-being. It also cautions on intake during pregnancy and when sugar or cream are added.

19 Aug 2025

Scientists link gut microbes to stronger muscles and healthier aging

Researchers discovered that gut microbes, including Lactobacillus reuteri and L. johnsonii, can enhance muscle strength in aging mice. Co-administration of these strains boosted muscle mass, performance, and reduced inflammation, pointing to a possible microbiome-based strategy for muscle health.

19 Aug 2025

Faulty glucose transport weakens insulin release in Type 2 diabetes

Just as smart traffic management ensures smooth vehicular movement during peak hours, our body relies on a molecular traffic system to manage the surge in glucose levels after a meal.

18 Aug 2025

Study shows promising anti-diabetic potential of coffee's functional components

Three of the compounds demonstrated significant inhibitory effects on α-glucosidase, a key enzyme in carbohydrate digestion. The findings could pave the way for new functional food ingredients targeting type 2 diabetes.

18 Aug 2025

Lactylation drives tumor progression and immune evasion in triple negative breast cancer

Breast cancer maintains its position as the most prevalent malignancy in women worldwide, with triple-negative breast cancer (TNBC) representing the most treatment-resistant subtype due to limited therapeutic targets and frequent relapse.

18 Aug 2025

Detecting diabetes risk by analyzing household data

New research to be presented at the 2025 Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (September 15-19, 2025) shows that early detection of individuals at risk for diabetes is possible by analyzing the electronic records of people living within the same household for risk factors. The study is led by Dr Tainayah Thomas, Stanford University, Palo Alto, CA, USA, and colleagues.

18 Aug 2025

Can ginger help diabetes? Major review says yes, it lowers blood sugar and inflammation effectively

A new systematic review of five meta-analyses confirms that ginger significantly reduces inflammation, lowers blood sugar and HbA1c in type 2 diabetes, and improves antioxidant status. It also effectively reduces nausea in pregnancy, though its impact on vomiting is less consistent.

17 Aug 2025

Portable device enables at-home monitoring of Parkinson’s disease symptoms

The number of people living with Parkinson's disease globally has doubled in the past 25 years.

17 Aug 2025

GIPR signaling opens brain’s gate for GLP-1 weight-loss therapy

A Cell Metabolism study reveals that GIPR signaling in oligodendrocytes enhances brain access and weight-loss efficacy of GLP-1R agonists by increasing vascular permeability and targeting appetite-regulating neurons. This mechanism may explain why GIPR/GLP-1R co-agonists outperform single-agent therapies.

14 Aug 2025

Surprising sweetness differences in popular U.S. infant formulas

A study on infant formulas reveals significant differences in sweetness, highlighting the impact of ingredients on children's nutrition and taste preferences.

14 Aug 2025

Research shows GLP-1 drugs safeguard vision despite small retinopathy risk

A large study of over 185,000 adults with type 2 diabetes found that GLP-1 receptor agonist use was linked to a slight increase in new diabetic retinopathy cases but fewer severe eye complications, including a reduced risk of blindness. Patients with existing retinopathy on these drugs also needed fewer invasive eye treatments over two years.

13 Aug 2025

Curcumin activates SIRT3 to protect bone structure in diabetic mice

In a new Scientific Reports study, curcumin protected bone-forming cells from high-glucose damage by activating the SIRT3/FoxO3a/NRF2 antioxidant pathway and restoring mitochondrial health. In diabetic mice, curcumin improved bone density and oxidative balance, highlighting its potential in osteoporosis prevention.

13 Aug 2025