Drug Discovery News and Research

RSS

The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Discovery of key proteins that regulate mitophagy could unlock new Parkinson's disease treatments Researchers At WEHI ...

Researchers at WEHI in collaboration with a team at the University of Vienna have discovered two proteins that act as regulators for mitophagy.

23 Jul 2024

Research shows the ability of proteins to predict onset of many diverse diseases

Research on thousands of proteins measured from a drop of blood demonstrates the ability of proteins to predict the onset of many diverse diseases.

22 Jul 2024

New study aims to examine how sleep patterns affect neurocognition in older women

Alzheimer's disease, the most common type of dementia, currently affects twice as many women as men, with minority populations predicted to witness the most significant increase in cases in the coming years, according to the Centers for Disease Control and Prevention.

16 Jul 2024

Optibrium appoints James Halle as Chief Commercial Officer

Key appointment brings extensive software commercial experience to drive global growth.

From Optibrium Ltd. 16 Jul 2024

Harnessing brain proteins for enhanced diabetes and weight-loss drugs

A network of proteins found in the central nervous system could be harnessed to increase the effectiveness and reduce the side effects of popular diabetes and weight-loss drugs, according to new research from the University of Michigan.

15 Jul 2024

ARPA-H funding boosts Wyss Institute's RNA therapeutic project

With the award for up to $27 million from the Advanced Research Projects Agency for Health (ARPA-H), a collaborative research project at the Wyss Institute for Biologically Inspired Engineering at Harvard University will advance a disease-agnostic novel RNA therapeutic with the potential to treat diverse diseases, and to be effectively and rapidly deployable.

15 Jul 2024

Revolutionary AI model improves early dementia diagnosis

Cambridge scientists have developed an artificially-intelligent tool capable of predicting in four cases out of five whether people with early signs of dementia will remain stable or develop Alzheimer’s disease.

13 Jul 2024

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Dispen3D is setting new standards in single-cell biology, enabling researchers to conduct high-precision experiments that drive advancements in drug discovery, personalized medicine, and regenerative therapies.

From SEED Biosciences 12 Jul 2024

FDA approved PDE4 inhibitor roflumilast for atopic dermatitis

On July 9th, 2024, the U.S. FDA approved Arcutis Biotherapeutics' ZORYVE® (roflumilast) for treating atopic dermatitis (AD), the most common type of eczema affecting millions in the U.S. This once-daily, steroid-free cream could become a new standard of care for AD.

From Sino Biological Inc. 12 Jul 2024

Innovative technique speeds up search for antimicrobial drug candidates

A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria.

11 Jul 2024

Researchers identify neurons in a small brain region that delay feeding initiation

Do you grab a fork and take a first bite of cake, or say no and walk away? Our motivation to eat is driven by a complex web of cells in the brain that use signals from within the body, as well as sensory information about the food in front of us, to determine our behaviors.

11 Jul 2024

60 years in the making: Nanoparticles revolutionize nucleotide delivery

Researchers trace the 60-year evolution of lipid nanoparticles (LNPs) for nucleic acid delivery, highlighting their potential to revolutionize gene therapy with safer and more effective treatments.

10 Jul 2024

Newcells Biotech appoints Emile Shaffu as Director of Sales

Newcells Biotech, a leading drug discovery partner specializing in developing in vitro models and bespoke assay services to improve the prediction of in vivo human outcomes, today announced the appointment of Emile Shaffu as Director of Sales.

From Newcells Biotech 9 Jul 2024

Case Western Reserve University receives $1.5M grant for oral drug trial to prevent blindness in RP patients

There's only one U.S. Food and Drug Administration-approved therapy for an inherited retinal disease, and dozens of retinitis pigmentosa (RP) genes for which no therapy is available.

8 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Protein biomarkers in spinal fluid offer promise for early progressive supranuclear palsy diagnosis

Progressive supranuclear palsy (PSP), a mysterious and deadly neurological disorder, usually goes undiagnosed until after a patient dies and an autopsy is performed.

3 Jul 2024

Pioneering Live Cell Imaging - Yokogawa's Impact and Innovations

In this interview, NewsMedical speaks with Kevin Jan from Yokogawa about the future of live cell imaging technologies.

From Yokogawa Life Science 3 Jul 2024

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

A major challenge in developing a vaccine for HIV is that the virus mutates fast - very fast. Although a person initially becomes infected with one or a few HIV strains, the virus replicates and mutates quickly, resulting in a "swarm" of viral strains existing in a single body.

2 Jul 2024

Modulating gene expression using small molecules

The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the proteins and most of the regulatory molecules in the cell.

2 Jul 2024

Optibrium demonstrates accelerated lead optimization in complex agrochemical development

Optibrium, a leading developer of software and AI solutions for molecular design today announced the publication of a peer-reviewed study in Journal of Computer-Aided Molecular Design, ‘From UK-2A to florylpicoxamid: Active learning to identify a mimic of a macrocyclic natural product’

From Optibrium Ltd. 2 Jul 2024

Drug Discovery News and Research

Further Reading

Discovery of key proteins that regulate mitophagy could unlock new Parkinson's disease treatments Researchers At WEHI ...

Research shows the ability of proteins to predict onset of many diverse diseases

New study aims to examine how sleep patterns affect neurocognition in older women

Optibrium appoints James Halle as Chief Commercial Officer

Harnessing brain proteins for enhanced diabetes and weight-loss drugs

ARPA-H funding boosts Wyss Institute's RNA therapeutic project

Revolutionary AI model improves early dementia diagnosis

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

FDA approved PDE4 inhibitor roflumilast for atopic dermatitis

Innovative technique speeds up search for antimicrobial drug candidates

Researchers identify neurons in a small brain region that delay feeding initiation

60 years in the making: Nanoparticles revolutionize nucleotide delivery

Newcells Biotech appoints Emile Shaffu as Director of Sales

Case Western Reserve University receives $1.5M grant for oral drug trial to prevent blindness in RP patients

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Protein biomarkers in spinal fluid offer promise for early progressive supranuclear palsy diagnosis

Pioneering Live Cell Imaging - Yokogawa's Impact and Innovations

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

Modulating gene expression using small molecules

Optibrium demonstrates accelerated lead optimization in complex agrochemical development

Free guide: Microplate reader solutions eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®