Hyperglycemia News and Research

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Hyperglycemia occurs when you have a higher than usual level of glucose in your blood. This can happen shortly after you have eaten a big meal and is not a problem if your glucose level returns to normal. Cells remove glucose from the blood in response toinsulin. If your pancreas doesn't make enough insulin, glucose can't enter the cells and remains in the blood. Blood glucose levels can also get too high if cells areunable to respond to insulin properly (insulinresistance). Without glucose, your cells are unable to make energy and can't function properly.

Metformin’s blood sugar control starts in the brain, not just the liver, study finds

Low, clinically relevant doses of metformin lower blood glucose by inhibiting the Rap1 protein in specific neurons of the hypothalamus, revealing a brain-first mechanism. This action is essential for metformin’s effect at therapeutic doses and highlights new directions for diabetes treatment.

3 Aug 2025

AI spots hidden diabetes risk even when test results look normal

Researchers used continuous glucose monitoring and multimodal data from over 3,000 people to reveal hidden patterns in glucose spikes across normoglycemia, prediabetes, and type 2 diabetes. Their AI-driven model exposed high individual variability and offers a personalized path for early detection and prevention of diabetes.

3 Aug 2025

New study shows brain's role in diabetic ketoacidosis

More than a decade ago, researchers found that an acute complication of type 1 diabetes, diabetic ketoacidosis (DKA), can be resolved with the hormone leptin, even in the absence of insulin.

1 Aug 2025

Analysis shows low pre-pregnancy glucose increases risk of preterm birth

An analysis of data from more than 4.7 million Chinese women showed that those who had low blood sugar levels prior to conception were more likely to have certain adverse pregnancy outcomes-such as their baby being born preterm or with low birth weight.

30 Jul 2025

Date vinegar lowers blood sugar and cholesterol in type 2 diabetes

This study reveals that red date vinegar intake improves blood glucose and lipid profiles in type 2 diabetes, indicating potential for metabolic risk reduction.

22 Jul 2025

Uncovering unexpected impacts of popular GLP-1 diabetes drugs

GLP-1 drugs show promise in diabetes management, offering heart and kidney benefits, but also highlight the need for vigilance regarding new health risks.

17 Jun 2025

Meal and sleep timing play key roles in diabetes prevention

High-resolution digital tracking reveals how daily habits, meal timing, sleep, and physical activity shape metabolic risk for type 2 diabetes. Meal timing, sleep patterns, and activity windows each play distinct roles in insulin resistance and glucose control.

12 Jun 2025

Variability in blood sugar response depends on individual's metabolic health status

A study led by researchers at Stanford Medicine shows that differences in blood sugar responses to certain carbohydrates depend on details of an individual's metabolic health status.

4 Jun 2025

New marker identifies the functional maturity and heterogeneity of stem cell–derived islet organoids

Over 500 million people worldwide suffer from diabetes-a disease that contributes to major complications such as stroke, kidney failure, cancer, and Alzheimer's disease.

4 Jun 2025

Choosing better carbs in low-carb diets boosts health outcomes

A long-term study of the Framingham Heart Study Offspring cohort found that low-carbohydrate diets emphasizing high-quality carbs, like whole grains, fruits, and vegetables, were linked to reduced inflammation and oxidative stress. Diets low in carbohydrate quality offered no such benefits.

29 May 2025

Cutting back on sugary drinks may protect men’s fertility, review finds

Regular consumption of sugar-sweetened beverages is associated with lower sperm count, motility, and increased DNA damage, potentially impairing male reproductive health. This narrative review highlights dose-response effects, mechanisms, and research gaps, calling for further studies on diverse populations.

22 May 2025

Targeting brain neurons to successfully treat type 2 diabetes

Successfully treating type 2 diabetes may involve focusing on brain neurons, rather than simply concentrating on obesity or insulin resistance, according to a study published today in the Journal of Clinical Investigation.

15 May 2025

Disrupted body clocks raise risk of early death, study finds

A large cohort study from China and the U.S. shows that Circadian Syndrome (CircS)—a cluster of metabolic and behavioral disruptions—is linked to higher all-cause and cause-specific mortality. The risk increases with the number of CircS components, especially among adults aged 40–60.

29 Apr 2025

Largest study to date reveals high blood sugar accelerates heart damage in healthy youth

In the present study, 1,595 adolescents drawn from the University of Bristol's Children of the 90s cohort were followed up from age 17 until 24 years. To assess the prevalence of prediabetes, which refers to high fasting blood glucose levels, two alternative cutpoints were used, a stricter cutpoint of ≥5.6 mmol/L recommended by the American Diabetes Association, and ≥6.1 mmol/L , which is the present recommendation in many countries.

29 Apr 2025

India, China, and the US will drive global diabetes burden by 2050, study finds

Global diabetes deaths and disability are rising, particularly in India, China, and the US, with type 2 diabetes (T2DM) driving the trend. Type 1 diabetes (T1DM) burdens are declining, but inequalities are widening, and projections show a steep rise in T2DM by 2050.

9 Apr 2025

New insights into miRNA roles in diabetic cardiomyopathy immune regulation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetic cardiomyopathy (DCM), an independent diabetes complication, is characterized by abnormalities in myocardial structure, function, and metabolism, including diminished myocardial contractility, myocardial hypertrophy, and fibrosis.

5 Mar 2025

One-hour glucose tolerance test could revolutionize postpartum diabetes screening

Caring for a baby is a full-time job, often causing new mothers to overlook their own health needs. This situation is exemplified by the low compliance with postpartum glucose screening among women who had gestational diabetes-a condition that significantly increases their risk of developing type 2 diabetes later in life.

3 Mar 2025

Review highlights next-generation cancer therapies targeting PIK3CA mutations

A newly published review in Genes & Diseases explores the oncogenic activation of PIK3CA in cancer and highlights emerging targeted therapies designed to improve treatment efficacy while reducing side effects.

25 Feb 2025

Eat this, not that: The best (and worst) foods for longevity

A comprehensive review of 41 studies analyzing over one million participants found that consuming nuts, whole grains, fruits, vegetables, and fish is linked to lower all-cause mortality, while processed and unprocessed red meat and sugar-sweetened beverages increase mortality risk.

19 Feb 2025

Study uncovers molecular mechanisms behind insulin resistance in skeletal muscle

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide.

19 Feb 2025