Immunomodulatory News and Research

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Hydrogel-based treatment achieves innervation and pulp-dentin regeneration

The dental pulp is susceptible to microbial infection, which often results in inflammation, necrosis, and defects in the pulp-dentin complex. Traditional treatment strategies suffer from multiple limitations and do not promote neural regeneration.

16 Dec 2025

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

Psoriasis caused by changes in the fat metabolism of skin cells

A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously unknown molecular mechanism that contributes to the development of psoriasis - and at the same time represents a potential biomarker for a new treatment concept.

11 Dec 2025

Engineered herpes virus activates potent immune responses against glioblastoma

Researchers at Mass General Brigham have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells.

4 Dec 2025

Black cumin: A promising natural agent with potential against chronic diseases

Black cumin seeds contain diverse secondary metabolites, including thymoquinone, flavonoids, triterpenoids and alkaloids, that demonstrate broad antimicrobial, antioxidant, anti-inflammatory and anticancer activity. Early preclinical and limited clinical evidence shows therapeutic potential across chronic diseases, supported by mechanistic and structure activity relationship findings.

24 Nov 2025

Kimchi consumption strengthens antigen recognition and immune regulation

Amid concerns about the simultaneous spread of multiple respiratory diseases, such as colds and influenza, with the change of seasons in current times, a recent clinical study has scientifically proven that kimchi, a traditional Korean fermented food, enhances the function of human immune cells and maintains the balance of the immune system.

24 Nov 2025

Pairing antiviral therapy with immune modulation restores lung repair in lethal Influenza

Recovery from deadly influenza infection may hinge on helping the lungs heal in addition to stopping the virus, according to a new study in mice, which shows that pairing modest antiviral therapies with immune modulation can restore damaged tissues and lung function, even after severe infection has taken hold.

20 Nov 2025

Can black cumin help fight obesity?

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20 Nov 2025

New patch may help heal the heart after a heart attack

A new patch developed by Texas A&M University researcher Dr. Ke Huang may offer a way to help the heart heal after a heart attack.

19 Nov 2025

What makes truffles more than a delicacy? They’re packed with bioactive compounds

Italian researchers reviewed the chemical composition and biological potential of truffles, identifying them as rich sources of antioxidants, polysaccharides, sterols, and vitamins. The review highlights their promise as functional foods and natural therapeutics, while emphasizing the need for sustainable cultivation and clinical validation.

11 Nov 2025

New precision therapies reshape the future of pancreatitis treatment

Pancreatitis remains a major global health burden, encompassing acute pancreatitis (AP), chronic pancreatitis (CP), and autoimmune pancreatitis (AIP).

11 Nov 2025

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Cervical squamous cell carcinoma (CESC), the most prevalent subtype of cervical cancer, remains a major global health burden driven primarily by persistent high-risk HPV infection and genetic susceptibility.

7 Nov 2025

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Lowering the transcription factor PU.1 reprograms microglia into a neuroprotective, lymphoid-like state that compacts amyloid, blocks tau spread, and preserves synapses in Alzheimer’s disease. Microglial CD28 signaling helps restrain inflammation, revealing a regulatory switch that may inform future immunotherapies targeting microglia rather than neurons.

6 Nov 2025

How walnuts combat inflammation and oxidative stress in the body

This review in Food Science & Nutrition synthesizes evidence showing that walnuts (Juglans regia L.) exert potent antioxidant, anti-inflammatory, apoptosis-regulatory, and immunomodulatory effects through bioactive compounds influencing mitochondrial, cytokine, and redox pathways.

3 Nov 2025

Exploring the gut-brain-immune axis in neurodegeneration

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), represent a growing global health burden, particularly in aging populations.

28 Oct 2025

Scientists identify Bidara leaf extracts as the most effective natural antimicrobial source

Researchers tested methanolic extracts from the leaves, bark, roots, stems, and fruits of Ziziphus mauritiana (Bidara) and found the leaves had the strongest antibacterial and antifungal effects. The study highlights the plant’s antimicrobial potential while emphasizing the need for further bioactive compound identification and toxicity testing.

22 Oct 2025

Stressful life factors early in life may triple the risk of developing psoriasis later

New longitudinal research reveals that severe stress caused by changes in family structure like divorce or separation experienced during the first year of life may triple the risk of developing psoriasis later in life.

21 Oct 2025

Genetic inflammatory signature defines depression subtypes and treatment response

Researchers led by Prof. Alessandro Serretti at Kore University of Enna have identified a genetic inflammatory signature that defines specific depression subtypes and influences how patients respond to antidepressant medications, according to new peer-reviewed research published today in Genomic Psychiatry.

21 Oct 2025

Decline in vitamin D levels observed during the Covid-19 pandemic

Routine data from laboratories reveal a decline in vitamin D levels during the Covid-19 pandemic, especially in older women and urban dwellers.

21 Oct 2025

How shifting antibodies fuel aging and the new therapies aiming to slow it

This review uncovers how aging reshapes immunoglobulins, particularly IgG, IgM, and IgA, driving inflammation, cellular senescence, and tissue degeneration. By dissecting B-cell dysfunction, glycosylation changes, and Fc receptor pathways, it reveals immunoglobulins as both biomarkers and potential therapeutic targets in aging.

14 Oct 2025

Immunomodulatory News and Research

Hydrogel-based treatment achieves innervation and pulp-dentin regeneration

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Psoriasis caused by changes in the fat metabolism of skin cells

Engineered herpes virus activates potent immune responses against glioblastoma

Black cumin: A promising natural agent with potential against chronic diseases

Kimchi consumption strengthens antigen recognition and immune regulation

Pairing antiviral therapy with immune modulation restores lung repair in lethal Influenza

Can black cumin help fight obesity?

New patch may help heal the heart after a heart attack

What makes truffles more than a delicacy? They’re packed with bioactive compounds

New precision therapies reshape the future of pancreatitis treatment

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

How walnuts combat inflammation and oxidative stress in the body

Exploring the gut-brain-immune axis in neurodegeneration

Scientists identify Bidara leaf extracts as the most effective natural antimicrobial source

Stressful life factors early in life may triple the risk of developing psoriasis later

Genetic inflammatory signature defines depression subtypes and treatment response

Decline in vitamin D levels observed during the Covid-19 pandemic

How shifting antibodies fuel aging and the new therapies aiming to slow it

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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