Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Eliminating dietary sugar may disrupt gut health and promote inflammation

Eliminating sugar from your diet may be more detrimental than previously thought, according to an animal study being presented Saturday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill.

14 Jun 2026

Excess weight identified as key driver for cardiovascular-kidney-metabolic syndrome

The first-ever clinical guideline for cardiovascular-kidney-metabolic syndrome, or CKM syndrome, identifies excess weight, especially in the abdomen, as a key driver for the syndrome. T

9 Jun 2026

Why exercise matters for obesity even when the scale barely moves

AHA's scientific statement reveals exercise's vital role in obesity management, boosting cardiovascular health and supporting long-term weight loss efforts.

4 Jun 2026

Scientists rethink GLP-1 delivery to improve dosing, tolerability, and adherence

The review highlights nanocarriers, microspheres, hydrogels, microneedles, long-acting formulations, and co-formulations as promising but mostly early-stage strategies that still require stronger long-term clinical evidence.

27 May 2026

Retatrutide reshapes metabolism in obesity and type 2 diabetes, study finds

Retatrutide altered circulating metabolites and lipids linked to fatty acid oxidation and insulin resistance in people with obesity, with or without type 2 diabetes. These biomarker changes suggest improved metabolic health, but the post-hoc analysis remains hypothesis-generating and does not prove direct clinical benefit.

26 May 2026

HonorHealth Research Institute tests steam therapy for diabetes treatment

HonorHealth Research Institute is looking to become the first research facility in the nation to begin a new clinical trial that aims to modify the lining of the digestive tract with the use of steam energy to control type II diabetes without the use of drugs.

21 May 2026

Gut-localized drug avoids systemic safety risks while reversing hormonal imbalances in mice

Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders in women of reproductive age. It can cause irregular periods, infertility, weight gain, insulin resistance, and elevated male hormone levels. Current treatments mainly focus on managing symptoms rather than addressing underlying causes.

20 May 2026

Global consortium renames polycystic ovary syndrome to reflect science

First, it was named after two men. Then, it was named for a false premise. Now, after more than a century, one of the most common hormone disorders affecting women worldwide has a name that reflects the science.

18 May 2026

Integrated care needed for lifelong Polyendocrine Ovarian Syndrome management

Polycystic Ovary Syndrome, which has just been renamed Polyendocrine Ovarian Syndrome (PMOS), is the most common hormonal and metabolic disorder affecting women of reproductive age, impacting up to 13% of this population and contributing to nearly 40% of infertility cases worldwide.

18 May 2026

Olive waste extract may help lower fat and improve muscle markers

A polyphenol-rich olive oil byproduct may enhance muscle health, reducing fat mass and improving antioxidant markers in adults with metabolic risk factors.

18 May 2026

Healthy plant-based foods may improve pregnancy cardiometabolic markers

Higher-quality plant-based diets were associated with more favorable cardiometabolic biomarkers in pregnant U.S. women, especially higher HDL-C and lower TG/HDL-C ratio. Indices that emphasized healthy plant foods, rather than simply penalizing animal foods, showed the strongest links with insulin resistance and lipid markers.

15 May 2026

Adult weight gain strongly linked to higher obesity-related cancer risk

New research presented at this year's European Congress on Obesity (ECO 2026) in Istanbul, Turkey (12-15 May) shows that people who gain the highest amount of weight across adulthood are at greatly increased risk of certain obesity related cancers.

13 May 2026

Why experts say PCOS needs a new name

A Lancet Health Policy paper reports an international consensus process that selected polyendocrine metabolic ovarian syndrome (PMOS) as the new name for polycystic ovary syndrome (PCOS). The change aims to shift the focus away from ovarian cysts and better reflect the condition’s endocrine, metabolic, and ovarian features.

13 May 2026

Gut microbes may reveal why diabetes raises heart disease risk

Integrated gut microbiome and plasma metabolomics profiling identified distinct microbial and metabolic signatures in people with T2DM and T2DM-CAD. In a small exploratory cohort, Bacteroides sp._CAG_875 and 12-ketoLCA emerged as candidate markers that may help distinguish diabetic patients with coronary complications, pending larger validation.

13 May 2026

Perimenopausal women face higher risk of low heart health

Perimenopausal women were two times more likely to have a low cardiovascular health score compared to women having regular menstrual cycles, according to an analysis of nationwide U.S. data published today in the Journal of the American Heart Association, an open-access, peer-reviewed journal of the American Heart Association.

13 May 2026

Maternal insulin resistance linked to higher abdominal fat in girls

Girls born to mothers with higher insulin resistance during the third trimester are more likely to have more abdominal fat at age 7, according to research presented at the 28th European Congress of Endocrinology in Prague.

12 May 2026

Study links metabolic dysfunction to cognitive impairment in bipolar disorder

While they share similar depressive and cognitive symptoms, the biological underpinnings of bipolar disorder and major depressive disorder are distinct.

11 May 2026

Urges for cardiologists to screen patients for UPF intake

The European Society of Cardiology identifies ultra-processed foods as a key cardiovascular risk, urging a shift in dietary guidelines for better heart health.

11 May 2026

Liver fat may disrupt post-meal glucagon control in early type 2 diabetes

Researchers found that MASLD, rather than type 2 diabetes alone, was linked to higher fasting glucagon levels in adults with newly diagnosed diabetes and matched controls. In people with early type 2 diabetes, higher liver fat was specifically associated with exaggerated early post-meal glucagon responses, independent of insulin sensitivity, visceral fat, amino acids, or NEFAs.

10 May 2026

Metformin targets the gut instead of the liver to lower glucose

For decades, physicians and scientists thought metformin, the leading Type 2 diabetes medication taken by millions worldwide, mainly targets the liver to suppress glucose production.

8 May 2026