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Why exercise is essential for restoring fitness after GLP-1-based weight loss

This randomized controlled trial shows that structured moderate-to-vigorous exercise, alone or combined with liraglutide, improves physical function and cardiorespiratory fitness after diet-induced weight loss in adults with obesity. In contrast, liraglutide alone sustains weight loss but does not significantly improve measured physical fitness outcomes.

26 Jan 2026

Arthritis significantly restricts employment for millions of American adults

According to new research from the University of Delaware, nearly 40% of American adults ages 18 to 64 with arthritis - almost 10 million people - say the medical condition is limiting their ability to work.

21 Jan 2026

$Six week casting proves as effective as surgery for unstable ankle fractures$

Six week casting proves as effective as surgery for unstable ankle fractures

Wearing a cast for six weeks appears to be no less effective than surgery for healing unstable ankle fractures and carries fewer treatment related harms, finds a clinical trial from Finland published by The BMJ today.

14 Jan 2026

HIF1 protein identified as key driver of tendon pain

Overuse of our tendons can cause painful medical conditions for which only limited treatment options exist. Researchers have now deciphered an important molecular mechanism that triggers these problems.

14 Jan 2026

Disease-responsive nanoparticles enable ghrelin mRNA therapy in osteoarthritis

Nitin Joshi, PhD, and Jingjing Gao, PhD, of the Department of Anesthesiology at Mass General Brigham, are the co-senior authors of a paper published in Nature Nanotechnology, "A disease-severity-responsive nanoparticle enables potent ghrelin mRNA therapy in osteoarthritis." Mahima Dewani, PhD, is the lead author of this study.

14 Jan 2026

Mpox clade Ib transmitted in a healthcare setting outside Africa

Mpox is a viral disease usually transmitted from animals to humans and symptoms include fever and skin rashes. In 2023, a new variant of monkeypox virus (MPXV), called clade Ib, emerged in Kamituga in the Democratic Republic of the Congo.

19 Dec 2025

Washington’s homeless hide in plain sight, growing sicker and costing taxpayers more

Every night, Abdullah Ibrahim retreats from the streets into a wooded stretch along the Potomac River.

18 Dec 2025

Rapid adoption of AI in primary care raises safety concerns

From digital scribes to ChatGPT, artificial intelligence (AI) is rapidly entering GP clinics. New University of Sydney research warns that technology is racing ahead of safety checks, putting patients and health systems at risk.

16 Dec 2025

Wheelchair? Hearing aids? Yes. ‘Disabled?' No way.

In her house in Ypsilanti, Michigan, Barbara Meade said, "there are walkers and wheelchairs and oxygen and cannulas all over the place."

11 Dec 2025

Trump’s idea for health accounts has been tried. Millions of patients have ended up in debt.

Sarah Monroe once had a relatively comfortable middle-class life. She and her family lived in a neatly landscaped neighborhood near Cleveland. They had a six-figure income and health insurance. Then, four years ago, when Monroe was pregnant with twin girls, something started to feel off.

9 Dec 2025

Study explores the impact of total knee replacement surgery cancellations across UK hospitals

Thousands of NHS knee replacement operations are cancelled at short notice every year, many for avoidable reasons, according to a new study published today [1 December].

1 Dec 2025

Study finds surprising differences in knee injuries between men and women

One of the largest MRI-based studies comparing knee injuries between men and women reveals surprising differences in injury patterns based on gender and age.

1 Dec 2025

Semaglutide helps older adults lose weight without immediate bone loss

Semaglutide shows potential for weight loss in older adults without harming bone density, but longer studies are essential to assess its effects on bone health.

1 Dec 2025

Fu's subcutaneous needling offers a safe non-pharmacological therapy for muscle-related pain

Chronic muscle tension is a common underlying factor in many pain disorders, causing reduced arterial blood flow, tissue hypoxia, and the release of inflammatory mediators.

28 Nov 2025

Blocking a ‘gerozyme’ reverses cartilage loss in mice

An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in the knee joints of old mice, a Stanford Medicine-led study has found.

28 Nov 2025

New trial to test extended tranexamic acid use for faster ACL surgery recovery

A breakthrough could be coming in the way young people recover from surgery to reconstruct the anterior cruciate ligament (ACL) in the knee, a common sports injury.

21 Nov 2025

New algorithm helps robotic prosthetics support more natural human movement

Researchers have developed a new algorithm that combines two processes for personalizing robotic prosthetic devices to both optimize the movement of the prosthetic limb and - for the first time - also help a human user's body engage in a more natural walking pattern.

20 Nov 2025

Chronic pain in adults linked to increased risk of developing high blood pressure

Chronic pain in adults may increase their risk of high blood pressure, and the location and extent of pain and if they also had depression were contributing factors, according to new research published today in Hypertension, an American Heart Association journal.

17 Nov 2025

Health care costs jump to the fore as candidates jockey to be California governor

California's gubernatorial election is a year away, and the field of primary candidates is still taking shape. But one persistent issue has already emerged as a leading concern: the cost of health care.

10 Nov 2025

GLP-1 drugs calm inflammation beyond diabetes and weight loss

This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

4 Nov 2025