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Did life-saving HIV drugs unintentionally fuel a syphilis comeback?

The introduction of HAART for HIV has coincided with a syphilis resurgence, suggesting unintended public health trade-offs from this medical breakthrough.

27 Apr 2026

Natural compound obakulactone shows therapeutic potential for rheumatoid arthritis

A new study published in Engineering reveals that obakulactone (OL), a natural tetracyclic triterpenoid isolated from Phellodendri cortex, exerts a therapeutic effect on rheumatoid arthritis (RA) by promoting the degradation of acyl coenzyme A thioesterase 1 (ACOT1) via the ubiquitin‒proteasome pathway and restoring the homeostasis of unsaturated fatty acids.

25 Apr 2026

Traditional plant extract may treat bone and mood disorders in postmenopausal women

Postmenopausal women are at higher risk for both osteoporosis and depression, yet no single treatment effectively addresses both conditions because their shared biological basis remains poorly understood.

25 Apr 2026

Bacterial vesicles emerge as powerful tools against antibiotic resistance

Antibiotic resistance is making bacterial infections harder to treat, demanding new therapeutic strategies. A new review highlights bacterial extracellular vesicles (BEVs) as promising nanoscale tools that can kill pathogens, block infection, enhance vaccines, and deliver drugs.

25 Apr 2026

Molecular map reveals how Down syndrome alters brain development

Scientists at UCLA have created one of the first cellular-resolution molecular maps detailing how Down syndrome alters human brain development before birth - a resource that resolves longstanding contradictions in the field and could lay the groundwork for future therapeutic strategies.

25 Apr 2026

Losing weight improves heart muscle contraction in people with obesity and heart failure

In a new research report, a team of scientists led by Johns Hopkins Medicine say people with severe obesity and a common type of heart failure experience weakened heart muscles, and that losing weight may reverse some of these effects.

25 Apr 2026

Researchers uncover new mechanism linking metabolism, immunity, and skeletal health

Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment.

25 Apr 2026

New strategy boosts natural killer cells to fight cancer

Scientists have developed a strategy to boost the cancer-fighting power of natural killer (NK) cells, part of the immune system's first line of defense.

24 Apr 2026

AI-assisted doctors perform better in complex clinical decision making

Artificial intelligence-powered chatbots are getting pretty good at diagnosing some diseases, even when they are complex.

24 Apr 2026

Exploiting a new weakness in 'zombie-like' cells to treat senescence-associated diseases

A new set of drugs exploit a recently-revealed weakness in 'zombie-like' – or senescent – cells that could lead to new treatments for cancer and age-associated diseases.

24 Apr 2026

Influenza D shows strong potential to spill over to humans

The influenza D virus that researchers say has been flying under the radar since its detection in animals in 2011 can vigorously make copies of itself in human cells and lung tissue samples, a new study shows.

24 Apr 2026

"Domino" heart valves from diseased organs could save thousands of children

A surgical innovation called partial heart transplantation could transform care for children with severe heart valve disease, allowing for thousands of additional valve transplants each year, according to a presentation delivered today by Joseph Turek, MD, PhD, at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual Meeting and Scientific Sessions.

24 Apr 2026

People judge weight loss more harshly when GLP-1 drugs are involved, study finds

In four pre-registered studies across Belgium, the US, and the UK, people judged anti-obesity medication users as putting in less effort and, in turn, viewed them as less moral, competent, warm, and deserving than non-users. The findings suggest that effort moralization may help drive stigma around GLP-1-based weight-loss treatment, even when medication is used alongside diet and exercise.

23 Apr 2026

Washington’s hepatitis C elimination initiative improves treatment access, reduces costs

It took less than 22 years after the discovery of the hepatitis C virus (HCV) for a fast-acting, highly effective treatment to become available.

23 Apr 2026

AI model rapidly designs new antibiotic to fight resistant bacteria

Researchers at McMaster University have developed a new generative artificial intelligence (AI) model capable of drastically speeding up drug discovery - and, in early tests, it has already designed a brand-new antibiotic.

23 Apr 2026

Endoscopic procedure may prevent weight regain after GLP-1 discontinuation

An outpatient procedure may offer a way for the estimated 70% of people who discontinue popular weight-loss drugs to avoid regaining the pounds they shed, according to a study to be presented at Digestive Disease Week (DDW) 2026.

23 Apr 2026

Researchers receive NIH grant to accelerate Alzheimer's drug discovery efforts

Dr. Damian Young, investigator at Texas Children's Duncan Neurological Research Institute (Duncan NRI) and director of the Center for Drug Discovery at Baylor College of Medicine, along with collaborators has been awarded a $6.7 million grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), to develop new approaches to rapidly identify potential treatments for Alzheimer's disease and related dementias with the goal of accelerating the discovery of new therapies.

23 Apr 2026

High levels of gut bacterial toxin linked to increased lupus nephritis risk

The body's immune reaction to increased levels of a toxic molecule, part of a bacterial species in the human gut, may reveal who is most at risk of developing lupus nephritis, according to a new study led by NYU Langone Health.

23 Apr 2026

Innovative light probes allow real-time visualization of cellular processes

Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals.

23 Apr 2026

Bioengineered chewing gum reduces cancer-linked oral microbes

Researchers led by Henry Daniell of the School of Dental Medicine have shown that extracts from bioengineered chewing gum reduce the levels of three microbes known to be associated with head and neck squamous cell cancer (HNSCC), paving the way for more effective and affordable therapies.

23 Apr 2026