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Bruker introduces Ultima Investigator Plus — Multiphoton microscope for tissue imaging

Bruker today announced the release of the Ultima Investigator Plus, the newest modular platform addition to the industry-leading Ultima line of multiphoton microscopes for deep tissue fluorescence imaging.

From Bruker Nano Surfaces and Metrology 30 Mar 2022

New tissue-clearing method could speed the study of many disease-related biological processes

Scientists at Scripps Research have unveiled a new tissue-clearing method for rendering large biological samples transparent.

29 Mar 2022

New technology could replace conventional biopsies and histology with real-time imaging

MediSCAPE, a high-speed 3D microscope designed by Columbia Engineers, can see real-time cellular detail in living tissues to guide surgery, speed up tissue analyses, and improve treatments.

28 Mar 2022

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

Researchers evaluated the stability and expression of mutations in the spike protein of SARS-CoV-2.

24 Mar 2022

Uptake of SARS-CoV-2 spike protein in human cerebrovascular cells

A recent study assessed the uptake of SARS-CoV-2 spike protein in human cerebrovascular cells via the lipid raft ganglioside.

24 Mar 2022

Quantum dots can quantify specific types of cells inside deep tissues of the body

To accurately diagnose and treat diseases, doctors and researchers need to see inside bodies. Medical imaging tools have come a long way since the humble x-ray, but most existing tools remain too coarse to quantify numbers or specific types of cells inside deep tissues of the body.

23 Mar 2022

Scientists find striking lane-like patterns in bacteria populations

It's well understood that populations of species don't distribute at random. Rather, as populations grow, individuals are organized around barriers in the landscape

22 Mar 2022

Antimalarial drugs are also effective at treating a pulmonary disease, study finds

A research team at Colorado State University has discovered that drugs used to treat malaria are also effective at treating a pulmonary disease similar to tuberculosis.

21 Mar 2022

How does the non-structural protein 1 affect COVID-19 pathogenicity?

Researchers discuss the effects of the SARS-CoV-2 non-structural protein 1 (Nsp1), which binds to the ribosomal subunit thus inhibiting translation.

20 Mar 2022

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers constructed a novel fusion inhibitor−based recombinant protein, referred to as 5−Helix, to block SARS-CoV-2 spike-mediated cell-cell fusion.

17 Mar 2022

Researchers develop extraction-free saliva RT-LAMP assay for workplace surveillance of SARS-CoV-2

Researchers developed a saliva-based, extraction-free reverse transcription loop-mediated isothermal amplification workflow for SARS-CoV-2 detection.

17 Mar 2022

SARS-CoV-2 infection model generated from human tonsil epithelial organoids

Researchers evaluate the feasibility of tonsil epithelial cell-derived organoids as an ex vivo model for studying SARS-CoV-2 infection.

15 Mar 2022

Sustainable material-based biosensors for SARS-CoV-2 detection

Researchers conducted a brief review on biosensors based on sustainable materials for SARS-CoV-2 detection.

15 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

CRIPSR identifies cell-type-specific ACE2 modifiers

Researchers compile a list of candidate genes to identify the surface abundance of functional regulators of ACE2.

9 Mar 2022

Intersectional, anterograde transsynaptic targeting system used to reveal two different brain circuits

Osaka Metropolitan University uses new “intersectional, anterograde transsynaptic targeting system” to reveal two different mouse brain circuits: the retina/primary visual cortex to the superior colliculus and the bilateral motor cortex to the dorsal striatum.

8 Mar 2022

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

In a recent study posted to the medRxiv*preprint server, a team of researchers from Israel developed and validated novel reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR) assays. The new assays enable the rapid and high throughput identification and differentiation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 and BA.2 variants.

8 Mar 2022

Identification of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding

Researchers discovered compounds able to inhibit SARS-CoV-2 macrodomain 1 and adenosine diphosphate-ribose binding via high throughput screening.

7 Mar 2022

Canopy Biosciences launches next-generation ChipCytometry™ instrument for spatial biology with sub-cellular resolution

Canopy Biosciences, a Bruker Company, today announced the commercial launch of the CellScape™ system, the next generation in ChipCytometry™ instrumentation, advancing the cutting-edge for quantitative in situ spatial phenotyping.

From Bruker Nano Surfaces and Metrology 7 Mar 2022