Preclinical News and Research

RSS

Bridging innovation and equity to end cervical cancer worldwide

Each year, more than 340,000 women die from cervical cancer, with the majority of deaths occurring in low- and middle-income countries.

13 Oct 2025

Advances in nanomaterials revolutionize therapy for myocardial ischemia-reperfusion injury

Ischemic heart disease is the leading cause of death globally, causing approximately 9 million deaths annually.

10 Oct 2025

How much caffeine is safe during pregnancy? New review finds no clear threshold

Caffeine's impact on pregnancy is nuanced; moderate consumption may not lead to major complications, but risks to fetal growth persist without a safe threshold.

10 Oct 2025

The ISSCR releases new resource to accelerate the development of PSC-derived therapies

The International Society for Stem Cell Research (ISSCR) is proud to announce the release of Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies, a comprehensive, interactive new resource designed to accelerate the translation of human pluripotent stem cell (PSC)-derived therapies into clinical trials and commercial use.

9 Oct 2025

GLP-1 therapeutics may have the potential to treat alcohol and drug addiction

A popular class of therapies for treating diabetes and obesity may also have the potential to treat alcohol and drug addiction, according to a new paper published in the Journal of the Endocrine Society.

9 Oct 2025

Discovery of vascular-associated fibroblastic cells opens new path for diabetes treatment

Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the cells that produce insulin-a critical hormone that regulates blood sugar in the body.

8 Oct 2025

UCSF team uncovers breakthrough immunotherapy for colon cancer liver metastases

Advanced colon cancer is the leading cause of cancer-related death in young American men and the second highest worldwide. In the majority of these patients, as the cancer advances it metastasizes to the liver.

8 Oct 2025

New brain circuit discovery offers hope for chronic pain relief

Acute or short-lived pain, despite its bad reputation, is usually a lifesaver. It acts as a transient negative sensory experience that helps us avoid danger.

8 Oct 2025

Engineered Salmonella therapy delivers immune payloads to combat cancer

A new research paper was published in Volume 16 of Oncotarget on October 6, 2025, titled "ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response."

8 Oct 2025

COMBINEDBrain and MUSC join forces to launch pediatric CNS biorepository

COMBINEDBrain, a leader in advancing translational neuroscience research, and the Medical University of South Carolina (MUSC), one of the nation's premier academic health centers, are excited to announce a strategic partnership to establish a cutting-edge biorepository for pediatric central nervous system (CNS) tissue and biofluids.

7 Oct 2025

Reelin protein may help heal both "leaky gut" and severe depression

What if a protein could be injected to help heal both "leaky gut" and severe depression? New research from the University of Victoria (UVic), published in Chronic Stress, shows that a glycoprotein called Reelin may one day be able to do just that.

7 Oct 2025

Researchers identify a central controller of mitochondrial dynamics in disease

A key switch for cellular energy balance has been discovered in cells: it could potentially become the target of new therapies for diseases ranging from Parkinson's to rare disorders caused by defects in the cell's powerhouses, the mitochondria.

6 Oct 2025

Study reveals new strategy to block TNBC metastasis and restore chromosomal stability

Triple negative breast cancer (TNBC) is one of the most aggressive and hardest forms of breast cancer to treat, but a new study led by Weill Cornell Medicine suggests a surprising way to stop it from spreading. Researchers have discovered that an enzyme called EZH2 drives TNBC cells to divide abnormally, which enables them to relocate to distant organs.

6 Oct 2025

Highly targeted gene therapy could revolutionize treatment for cancers linked to herpesvirus

In a preclinical study, UC Davis Comprehensive Cancer Center scientists developed a highly targeted gene therapy that could revolutionize treatment for cancers linked to a common herpesvirus, with minimal side effects.

2 Oct 2025

Neurological outcomes after cardiac arrest found to be similar across income levels

People who have a cardiac arrest in their own homes have similar neurological outcomes regardless of socioeconomic background, according to research presented at the European Emergency Medicine Congress today (Wednesday).

2 Oct 2025

How the University of Manchester used Bruker equipment to map the dynamics of complex protein

Discover how Bruker and the University of Manchester joined forces to discover more on the dynamics of complex protein.

From Bruker BioSpin Group 2 Oct 2025

Small molecule AVJ16 shows promise in targeting lung cancer growth

Researchers have discovered a promising new approach to lung cancer treatment. A small molecule called AVJ16 selectively blocks the cancer-driving protein IGF2BP1, halting tumor growth in preclinical studies and killing cancer cells in patient-derived models—while leaving healthy cells unharmed.

29 Sep 2025

How maternal microbes shape babies’ gut health and disease risk

Early microbial exposures from maternal microbes, milk components, and the environment shape infant gut development and long-term disease risk. The review highlights mechanisms, preventive levers, and research gaps in supporting healthy microbiome inheritance across generations.

29 Sep 2025

Cannabidiol shows promise for obesity and metabolic syndrome

Cannabidiol (CBD) shows promise in regulating appetite, glucose and lipid metabolism, and inflammation in preclinical models of obesity and metabolic syndrome. However, human evidence is still limited, highlighting the need for rigorous trials before clinical use.

29 Sep 2025

Can a mango a day keep diabetes away?

The study reveals that daily mango consumption may enhance insulin sensitivity and reduce body fat in prediabetic adults, emphasizing whole fruits' advantages.

29 Sep 2025

Preclinical News and Research

Bridging innovation and equity to end cervical cancer worldwide

Advances in nanomaterials revolutionize therapy for myocardial ischemia-reperfusion injury

How much caffeine is safe during pregnancy? New review finds no clear threshold

The ISSCR releases new resource to accelerate the development of PSC-derived therapies

GLP-1 therapeutics may have the potential to treat alcohol and drug addiction

Discovery of vascular-associated fibroblastic cells opens new path for diabetes treatment

UCSF team uncovers breakthrough immunotherapy for colon cancer liver metastases

New brain circuit discovery offers hope for chronic pain relief

Engineered Salmonella therapy delivers immune payloads to combat cancer

COMBINEDBrain and MUSC join forces to launch pediatric CNS biorepository

Reelin protein may help heal both "leaky gut" and severe depression

Researchers identify a central controller of mitochondrial dynamics in disease

Study reveals new strategy to block TNBC metastasis and restore chromosomal stability

Highly targeted gene therapy could revolutionize treatment for cancers linked to herpesvirus

Neurological outcomes after cardiac arrest found to be similar across income levels

How the University of Manchester used Bruker equipment to map the dynamics of complex protein

Small molecule AVJ16 shows promise in targeting lung cancer growth

How maternal microbes shape babies’ gut health and disease risk

Cannabidiol shows promise for obesity and metabolic syndrome

Can a mango a day keep diabetes away?

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics