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Unveiling the dual role of HIV integrase in viral replication

The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most common HIV strain.

24 Oct 2025

Researchers identify nervous system components driving gastrointestinal cancer growth

Australian researchers have identified two nervous system components that drive tumor growth in gastrointestinal cancers, creating promising new avenues for treatment with existing approved therapies.

24 Oct 2025

GemPharmatech collaborates with MSK Cancer Center to accelerate discovery of therapeutic antibodies

GemPharmatech, a global leader in preclinical research solutions and genetically-engineered mouse models, today announced a collaboration with Memorial Sloan Kettering Cancer Center (MSK) to accelerate the discovery of new therapeutic antibodies.

23 Oct 2025

New York Regional Diabetes Research Center established with $10.8 million NIH grant

Albert Einstein College of Medicine has received a five-year, $10.8 million grant from the National Institutes of Health (NIH) to create the New York Regional Diabetes Research Center (NYR-DRC), a newly expanded multi-institutional center co-led with the Icahn School of Medicine at Mount Sinai and Weill Cornell Medicine.

23 Oct 2025

Semaglutide can offer important heart benefits that go beyond weight loss

A new analysis of the SELECT trial – the largest and longest clinical trial to date examining the cardiovascular benefits of semaglutide (a medication used to support weight loss and diabetes management) – confirms it also lowers the risk of major heart problems in people who are overweight or obese and already have heart disease, even if they don't have diabetes.

23 Oct 2025

Biodesix announces expanded Bio-Rad Laboratories partnership agreement to develop Droplet Digital™ PCR high complexity assays

Biodesix, Inc., a leading diagnostics solutions company, today announced the signing of an expanded partnership agreement under which Biodesix will conduct the development, clinical validation, and regulatory submissions of in vitro diagnostic (IVD) assays to enable highly sensitive detection of multiple genomic markers focused on oncology applications, utilizing Bio-Rad's Droplet Digital™ PCR (ddPCR™) technology on Bio-Rad's QX600 platform.

23 Oct 2025

Analysis highlights the differing physical side effects of antidepressants

Antidepressants can differ widely in how they physically affect the body, including around a 4 kg difference in weight change between certain drugs (approximately 2.5 kg weight loss from agomelatine and 2kg weight gain from maprotiline), confirms a systematic review and meta-analysis published in The Lancet.

22 Oct 2025

New technology can track beneficial bacteria after fecal microbiota transplants

Researchers at the Icahn School of Medicine at Mount Sinai and their collaborators have developed a new technology to track beneficial bacteria after fecal microbiota transplants (FMT).

22 Oct 2025

$VT3989 shows promising antitumor activity in refractory mesothelioma patients$

VT3989 shows promising antitumor activity in refractory mesothelioma patients

The first-in-class YAP-TEAD inhibitor VT3989 continued to be well tolerated and demonstrated notable initial antitumor activity, particularly in patients with refractory mesothelioma, according to results from a trial led by researchers from The University of Texas MD Anderson Cancer Center.

22 Oct 2025

Discovery offers a breakthrough approach to combat prostate tumor growth

Prostate cancer relies on genetic "switches", called enhancers, that can turn on tumor-promoting genes.

22 Oct 2025

Fortress, filter, and gatekeeper: New insights into how the blood-brain barrier safeguards the brain

Researchers provide a comprehensive overview of the blood-brain barrier (BBB), detailing its cellular architecture, transport mechanisms, and role in protecting the brain from toxins. The paper highlights how BBB dysfunction contributes to neurological diseases and explores emerging technologies to overcome drug delivery challenges.

21 Oct 2025

Epigenetic editing enables safer and more effective T cell therapies

Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that enables safe modification of multiple genes in primary human T cells, addressing a key manufacturing and scalability challenge in next-generation cell therapies.

21 Oct 2025

New study offers hope for patients with treatment-resistant focal epilepsy

About one-third of patients with focal epilepsy, a common form of the neurological disorder, are believed to respond poorly to available therapies.

21 Oct 2025

Cyclana Bio raises £5M to advance drug discovery for endometriosis

Cyclana Bio, a biotechnology company pioneering tissue-level approaches to women's health, today announced the close of a £5M pre-seed funding round, co-led by NfX and Eka VC, and including Cocoa VC, Wilbe, and Angel investors.

21 Oct 2025

Genetic and inflammatory factors amplify the link between earlier menopause and cognitive risk

Women are significantly more likely than men to develop Alzheimer's disease. Earlier age at menopause is associated with a greater risk for late-life cognitive decline and Alzheimer's disease.

21 Oct 2025

Study reveals protein plaques in neurodegeneration function as enzymes, breaking down ATP

A new study led by Rice University's Pernilla Wittung-Stafshede has revealed that protein clumps, or plaques that clog the brain, associated with Parkinson's disease are not merely waste; they can actively drain energy from brain cells.

21 Oct 2025

Novel combination therapy shows promise for advanced neuroendocrine tumors

A novel combination therapy pairing a DNA-synthesis inhibitor with a targeted radiopharmaceutical may improve outcomes for patients with advanced neuroendocrine tumors, according to new clinical trial data presented this week at the European Society for Medical Oncology (ESMO) Congress 2025.

21 Oct 2025

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer's Disease by Impairing Microglial Function."

17 Oct 2025

Scientists discover why a powerful leukemia drug fails in most patients

Researchers from Rutgers Health and other institutions have discovered why a powerful leukemia drug eventually fails in most patients – and found a potential way to overcome that resistance.

17 Oct 2025

Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1

A class of antivirals called Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1 (HSV-1), the common infection behind oral herpes, according to new research published in Antiviral Research on July 25.

17 Oct 2025