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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

AI tool reveals how TB drugs kill bacteria at the molecular level

Tuberculosis (TB) is the world's deadliest infectious disease—and one of the hardest to cure. Standard treatment requires a cocktail of multiple drugs over at least six months, and one in five patients have a type of TB that resists these first-line medications.

25 Aug 2025

New molecular mechanism offers hope for treating depression in the elderly

Major depressive disorder (MDD) is one of the most common psychiatric illnesses worldwide, but its molecular causes have still not been clearly identified.

25 Aug 2025

How a single gene reshapes pain perception through polyamine signaling

Researchers have identified SLC45A4 as a neuronal polyamine transporter genetically linked to human chronic pain. Loss of this gene in mice disrupts polyamine balance, alters spinal GABA levels, and reduces heat and tonic pain sensitivity.

24 Aug 2025

Next-gen sequencing reveals the regulatory potential of the non-coding genome

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark achievements of the Human Genome Project (HGP), scientists have increasingly focused on deciphering the non-coding regions of the human genome, which comprise approximately 98% of the genetic material.

23 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

Single-cell proteomic analysis uncovers hidden layers of blood cell formation

In the past decade there has been significant interest in studying the expression of our genetic code down to the level of single cells, to identify the functions and activities of any cell through the course of health or disease.

21 Aug 2025

Yale researchers uncover new RNA editing tools for safer genetic surgery

The ability to correct disease-causing genetic mistakes using genome editors holds great promise in medicine, but it is not without risk.

21 Aug 2025

Computational approach provides insight into neural progenitor cells and their role in brain disorders

For much of the 20th century it was thought that the adult brain was incapable of regeneration. This view has since shifted dramatically and neurogenesis – the birth of new neurons – is now a widely accepted phenomenon in the adult brain, offering promising avenues for treating many neurological conditions.

21 Aug 2025

Virus inside the fungus drives deadly fungal infections

Researchers have discovered that a virus living inside the fungus Aspergillus fumigatus significantly boosts the fungus's ability to survive stress and cause severe infections in mammals.

21 Aug 2025

Breakthroughs in diagnosis and therapy for transthyretin amyloidosis

Transthyretin amyloidosis (ATTR) is caused by the misfolding and aggregation of the transthyretin (TTR) protein, leading to multi-organ damage.

21 Aug 2025

How the Vutara VXL simplifies single-molecule imaging

Explore how the Bruker Vutara VXL advances single-molecule imaging across DNA, RNA, and proteins

From Bruker Nano Surfaces and Metrology 20 Aug 2025

COVID-19 accelerates vascular aging in women

Research shows COVID-19 accelerates vascular aging, especially in women, with implications for long-term cardiovascular health and recovery strategies.

20 Aug 2025

Scientists link gut microbes to stronger muscles and healthier aging

Researchers discovered that gut microbes, including Lactobacillus reuteri and L. johnsonii, can enhance muscle strength in aging mice. Co-administration of these strains boosted muscle mass, performance, and reduced inflammation, pointing to a possible microbiome-based strategy for muscle health.

19 Aug 2025

Researchers gain better understanding of how nerve cells can be protected against ALS

By analyzing millions of messenger RNA molecules (mRNA) during the course of ALS, researchers at Stockholm University, in collaboration with scientists at the Paris Brain Institute and Örebro University, have identified why certain nerve cells are resistant to the disease and what happens in the sensitive nerve cells when they are affected.

19 Aug 2025

HPV16 reprograms immune cells to weaken cancer defenses

The most common cancer-causing strain of human papillomavirus (HPV), HPV16, undermines the body's defenses by reprogramming immune cells surrounding the tumor, according to new research from the Keck School of Medicine of USC.

19 Aug 2025

How a Réunion Island outbreak sparked France’s record chikungunya season

Mainland France recorded its earliest-ever local chikungunya outbreaks in May 2025, with 10 clusters (27 cases) across five regions, driven by travelers importing the virus from Réunion Island. The surge highlights growing vulnerability to mosquito-borne diseases in Europe as Aedes albopictus expands northward.

18 Aug 2025