Therapeutics News and Research

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Repeated sampling offers insight into glioblastoma therapy response

A multi-institutional study from the Accelerating GBM Therapies Through Serial Biopsies TeamLab, led by investigators from the Mass General Brigham Cancer Institute, found that serially testing tumor samples can help detect when a cancer treatment is activating the immune system in recurrent glioblastoma (GBM), even when traditional imaging measures cannot.

8 Oct 2025

X-HiDE project advances toward earlier detection and precision treatment of inflammatory diseases

Facilitating earlier diagnosis and more precise treatment for patients with inflammatory diseases. This is the goal as the X-HiDE research project at örebro University in Sweden now enters its next phase, in collaboration with eleven companies and four other universities in Europe and the USA.

8 Oct 2025

Engineered Salmonella therapy delivers immune payloads to combat cancer

A new research paper was published in Volume 16 of Oncotarget on October 6, 2025, titled "ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response."

8 Oct 2025

Engineered CAR-NK cells show enhanced cancer killing and immune evasion

One of the newest weapons that scientists have developed against cancer is a type of engineered immune cell known as CAR-NK (natural killer) cells. Similar to CAR-T cells, these cells can be programmed to attack cancer cells.

8 Oct 2025

Aptamer expands into targeted radiopharmaceuticals with major top 3 pharma contract

Aptamer Group plc, the developer of next-generation synthetic binders for the life sciences industry, has announced a significant development contract with a top 3 global pharmaceutical company to engineer Optimer® binders as targeted radiopharmaceuticals for potential therapeutic applications.

8 Oct 2025

Second World Congress to spotlight the science behind mitochondrial biology and microbiome research

The Second World Congress on Targeting Extracellular Vesicles (EVs) is scheduled for 15–16 October 2025 in Valencia, Spain. This landmark event, co-organized by the World Mitochondria Society and the International Society of Microbiota, will spotlight the rapidly evolving science where mitochondrial biology and microbiome research intersect via extracellular vesicles.

7 Oct 2025

New computer-driven method helps understand how membrane proteins work at the atomic level

Cellular membrane proteins play many important roles throughout the body, including transporting substances in and out of the cell, transmitting signals, speeding up reactions and helping neighboring cells stick together.

7 Oct 2025

Reelin protein may help heal both "leaky gut" and severe depression

What if a protein could be injected to help heal both "leaky gut" and severe depression? New research from the University of Victoria (UVic), published in Chronic Stress, shows that a glycoprotein called Reelin may one day be able to do just that.

7 Oct 2025

State-of-the-art microchips help understand how sepsis and neurodegenerative diseases damage the brain

In lieu of animal experiments, researchers from the University of Rochester are using state-of-the-art microchips with human tissue to better understand how the brain operates under healthy conditions and is damaged through neurodegenerative diseases or conditions like sepsis.

7 Oct 2025

Discovery opens up new avenues for treating rotavirus infections

Rotavirus causes severe dehydrating diarrhea in infants and young children, contributing to more than 128,500 deaths per year globally despite widespread vaccination efforts.

7 Oct 2025

AI, omics, and systems biology could transform heart drug development

AI, omics, and systems biology can now help scientists design targeted drugs for cardiovascular disease pathways once thought "untreatable."

7 Oct 2025

Researchers design intrinsically disordered proteins with tailored properties

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using computers to accurately predict the 3D structure of any given amino acid sequence.

7 Oct 2025

'Good' gut microbe found to support fetal growth and reduce pregnancy risks

Research led by the University of Cambridge has found the first clear evidence that the 'good' gut bacteria Bifidobacterium breve in pregnant mothers regulates the placenta's production of hormones critical for a healthy pregnancy.

6 Oct 2025

Milken Institute and Ann Theodore Foundation award over $2.5 million for sarcoidosis research

The Milken Institute Science Philanthropy Accelerator for Research and Collaboration (SPARC), in partnership with the Ann Theodore Foundation (ATF), today announced that the Ann Theodore Foundation Breakthrough Sarcoidosis Initiative (ATF-BSI) has awarded five grants totaling more than $2.5 million to interdisciplinary research teams.

6 Oct 2025

New survey reveals Americans' perception of the growing need for plasma-derived medicines

International Plasma Awareness Week (IPAW) takes place globally from October 6-10. The week encourages communities around the world to recognize the vital role of plasma in creating lifesaving medicines and honors those who donate.

6 Oct 2025

AI-designed proteins revolutionize gene editing precision and safety

Researchers at Integra Therapeutics, in collaboration with the Pompeu Fabra University (UPF) Department of Medicine and Life Sciences (MELIS) and the Center for Genomic Regulation (CRG), have designed and experimentally validated new synthetic proteins that can edit the human genome more efficiently than proteins provided by nature.

6 Oct 2025

Highly targeted gene therapy could revolutionize treatment for cancers linked to herpesvirus

In a preclinical study, UC Davis Comprehensive Cancer Center scientists developed a highly targeted gene therapy that could revolutionize treatment for cancers linked to a common herpesvirus, with minimal side effects.

2 Oct 2025

Study finds limited value of CGM data for non-diabetic individuals

Continuous glucose monitors (CGMs) are wearable technologies that track blood sugar in real time and help patients with type 2 diabetes improve blood sugar control.

2 Oct 2025

Engineered CAR T cells show promise against solid tumors

Chimeric antigen receptor (CAR) T cell therapy, which uses a patient's own immune cells to fight cancer, has emerged as a powerful way to treat lymphoma and other blood cancers.

2 Oct 2025

New data analysis method accelerates design of safer covalent inhibitors

Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent Occupancy Kinetic Enrichment via Proteomics) that provides a comprehensive, unbiased view of how a class of drugs, called covalent inhibitors, interacts with proteins throughout the cell.

30 Sep 2025

Therapeutics News and Research

Repeated sampling offers insight into glioblastoma therapy response

X-HiDE project advances toward earlier detection and precision treatment of inflammatory diseases

Engineered Salmonella therapy delivers immune payloads to combat cancer

Engineered CAR-NK cells show enhanced cancer killing and immune evasion

Aptamer expands into targeted radiopharmaceuticals with major top 3 pharma contract

Second World Congress to spotlight the science behind mitochondrial biology and microbiome research

New computer-driven method helps understand how membrane proteins work at the atomic level

Reelin protein may help heal both "leaky gut" and severe depression

State-of-the-art microchips help understand how sepsis and neurodegenerative diseases damage the brain

Discovery opens up new avenues for treating rotavirus infections

AI, omics, and systems biology could transform heart drug development

Researchers design intrinsically disordered proteins with tailored properties

'Good' gut microbe found to support fetal growth and reduce pregnancy risks

Milken Institute and Ann Theodore Foundation award over $2.5 million for sarcoidosis research

New survey reveals Americans' perception of the growing need for plasma-derived medicines

AI-designed proteins revolutionize gene editing precision and safety

Highly targeted gene therapy could revolutionize treatment for cancers linked to herpesvirus

Study finds limited value of CGM data for non-diabetic individuals

Engineered CAR T cells show promise against solid tumors

New data analysis method accelerates design of safer covalent inhibitors

Industry Focus eBook - Biotechnology (4th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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