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New method enables simultaneous multi-color imaging with bioluminescent proteins

Imaging live cells with fluorescent proteins has long been a crucial technique for understanding cellular behavior. While bioluminescent proteins offer several advantages over fluorescent proteins, the limited availability of color variants has made it difficult to observe multiple targets simultaneously.

23 Jan 2025

Study identifies new molecular target for treating keloids

Keloids are fibrotic scars that extend beyond the boundaries of the original wound, often causing physical disfigurement and emotional distress.

22 Jan 2025

APOBEC proteins linked to DNA repeat expansion in Huntington's disease

People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time.

22 Jan 2025

Research reveals sex differences in microglia response to injury

A collision happens. Someone is hurt, a head injury, a concussion. Just as the first responders arrive to help the person, inside the brain, another "crew" of responders is busy clearing debris and repairing injured tissue.

21 Jan 2025

Breakthrough study maps critical structure of Nipah virus polymerase

Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical component of the Nipah virus, a highly lethal bat-borne pathogen that has caused outbreaks in humans almost every year since it was identified in 1999.

20 Jan 2025

New research identifies metabolic targets to combat antibiotic-resistant bacterial infections

Targeting unique metabolic pathways in pathogens offers a novel approach to precision antibiotics, addressing the growing challenge of antimicrobial resistance.

17 Jan 2025

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in PTPN2.

17 Jan 2025

Scientists unveil global patterns in early-life gut microbial evolution

Scientists reveal that early-life gut microbiome development follows universal patterns, paving the way for new benchmarks in child health assessments.

15 Jan 2025

PIN1 protein found to be a significant driver of bladder cancer

Like all cancers, bladder cancer develops when abnormal cells start to multiply out of control. But what if we could put a lid on their growth?

15 Jan 2025

Study links epigenetic mechanism to placental blood vessel development

If the development of blood vessels in the placenta is impaired, fetal growth retardation may result. Scientists from the German Cancer Research Center (DKFZ) and the Mannheim Medical Faculty of Heidelberg University discovered that the correct development of functioning blood vessels in the mouse placenta is controlled epigenetically: One of the enzymes that modify gene activity using methyl groups is responsible.

15 Jan 2025

A new strategy for enhancing the production of protein-based drugs

An international team of researchers led by the University of California San Diego has developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.

15 Jan 2025

Research reveals inaccuracies in common gene therapy measurement technique

In a finding with implications for one of the most promising cutting-edge medical treatments, researchers evaluated several measurement techniques commonly used in gene therapy.

13 Jan 2025

Enhanced biosensing technology detects molecules at lower concentrations

An unplugged electric instrument may function, but it sounds much better when it is connected to an amplifier.

13 Jan 2025

Most disease-causing mutations that swap amino acids do so by making proteins less stable

Research shows 60% of missense mutations destabilize proteins, linking protein folding to genetic diseases, including cataracts and neurological disorders.

10 Jan 2025

Sex-specific mitochondrial marker deficiencies linked to early cognitive dysfunction in Alzheimer’s disease

Research reveals sex-specific free-carnitine deficiency in women with cognitive impairment, linking mitochondrial metabolism to Alzheimer's disease progression.

10 Jan 2025

Computer model helps tailor CML treatment to individual patients

Which medicine is best when you are affected by cancer? This can vary from person to person. A new method can help people with a specific type of blood cancer get the best medicine for them.

9 Jan 2025

New antibiotic shows promise in fighting tuberculosis

A consortium including scientists from the Tropical Institute at LMU University Hospital has demonstrated the effectiveness of a new antibiotic.

9 Jan 2025

Groundbreaking G6PD diagnostic test prequalified by WHO to ensure safe malaria treatment

On 18 December 2024, the World Health Organization (WHO) prequalified the first diagnostic test for glucose-6-phosphate dehydrogenase (G6PD) deficiency which can help to safely deliver WHO-recommended treatments to prevent relapse of Plasmodium vivax (P. vivax) infection.

9 Jan 2025

Ingenza partners with HydRegen to advance sustainable biomanufacturing

Ingenza's collaboration with HydRegen focuses on optimizing enzyme expression, paving the way for greener, cost-effective manufacturing of amine chemicals.

From Ingenza Ltd 9 Jan 2025

Gut microbes and the body work together to regulate fat metabolism

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce Thompson Institute at Cornell University's Ithaca campus.

9 Jan 2025