Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

Understanding mitochondrial biology in alcohol-associated liver disease and cancer

For decades, giant mitochondria-known as megamitochondria-have been recognized in liver biopsies from patients with alcohol-associated liver disease (ALD).

1 Jun 2026

Scientists rethink GLP-1 delivery to improve dosing, tolerability, and adherence

The review highlights nanocarriers, microspheres, hydrogels, microneedles, long-acting formulations, and co-formulations as promising but mostly early-stage strategies that still require stronger long-term clinical evidence.

27 May 2026

How the right diet could support the gut bacteria that matter most

This review examines how gut keystone bacteria shape microbiome stability, disease risk, and responses to diet. It highlights why better identification methods, experimental validation, and precision diet-probiotic strategies are needed to restore gut homeostasis.

26 May 2026

Retatrutide reshapes metabolism in obesity and type 2 diabetes, study finds

Retatrutide altered circulating metabolites and lipids linked to fatty acid oxidation and insulin resistance in people with obesity, with or without type 2 diabetes. These biomarker changes suggest improved metabolic health, but the post-hoc analysis remains hypothesis-generating and does not prove direct clinical benefit.

26 May 2026

Chronic liver disease threatens millions across Europe, report finds

Europe is facing a growing chronic liver disease threat, according to a new Series published today in The Lancet Regional Health – Europe, that engaged more than 75 co-authors from 30 countries and was led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by the "la Caixa" Foundation.

25 May 2026

Pioneering cell therapy offers hope for advanced liver disease

A new type of cell therapy shows promise as the first treatment for advanced liver disease, following results from a clinical trial.

25 May 2026

Novel RNA modification mechanism drives metabolic fatty liver disease progression

Nonalcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder with a complex pathogenesis. Although epitranscriptomic modifications such as N6-methyladenosine (m6A) have been implicated in NAFLD, the role of N1-methyladenosine (m1A) and its regulators is largely unexplored.

25 May 2026

Optimized extended PCLS culture system extends tissue viability up to two weeks

Precision-cut liver slice (PCLS) technology has long been regarded as a promising ex vivo platform because it preserves the native multicellular architecture of liver tissue.

22 May 2026

Oral drug improves platelet recovery during chemotherapy in gastrointestinal cancer patients

An oral medication already approved for thrombocytopenia in patients with liver disease significantly improved platelet recovery and helped patients with gastrointestinal cancers maintain platelet counts needed to continue chemotherapy as scheduled, according to results from a phase 2 clinical trial led by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and Mass General Hospital.

21 May 2026

Fatty liver disease linked to higher risk of heart attacks

Researchers at Mass General Brigham Heart and Vascular Institute found that people with hepatic steatosis, commonly called "fatty liver disease," have a higher amount of noncalcified, rupture-prone coronary plaque and face nearly twice the rate of cardiovascular events compared to those without steatosis.

20 May 2026

Global consortium renames polycystic ovary syndrome to reflect science

First, it was named after two men. Then, it was named for a false premise. Now, after more than a century, one of the most common hormone disorders affecting women worldwide has a name that reflects the science.

18 May 2026

Endoscopic sleeve gastroplasty outperforms oral semaglutide in short-term weight loss

A comparative study, presented at ESGE Days 2026, has found that endoscopic sleeve gastroplasty (ESG) is associated with significantly greater short-term weight loss than oral semaglutide in adults with obesity.

15 May 2026

New imaging technique maps 38000 liver cells to solve fibrosis

The liver is often called a "silent organ," as it can sustain significant damage without obvious symptoms. But when injury is prolonged, whether from alcohol, poor diet, or chronic hepatitis virus infection, it triggers fibrosis: a progressive hardening and scarring of liver tissue.

14 May 2026

Research links specific diets to reduced biological age

Older Australians who reduce either dietary fat or animal-based protein show signs of reduced biological age, new research from the University of Sydney shows.

11 May 2026

Urges for cardiologists to screen patients for UPF intake

The European Society of Cardiology identifies ultra-processed foods as a key cardiovascular risk, urging a shift in dietary guidelines for better heart health.

11 May 2026

Liver fat may disrupt post-meal glucagon control in early type 2 diabetes

Researchers found that MASLD, rather than type 2 diabetes alone, was linked to higher fasting glucagon levels in adults with newly diagnosed diabetes and matched controls. In people with early type 2 diabetes, higher liver fat was specifically associated with exaggerated early post-meal glucagon responses, independent of insulin sensitivity, visceral fat, amino acids, or NEFAs.

10 May 2026

Asthma medication formoterol shows promise for treating fatty liver disease

MUSC researchers are tackling MASH, or metabolic dysfunction-associated steatohepatitis, a liver disease affecting hundreds of millions worldwide.

8 May 2026

Specific health labels may better motivate reduced alcohol consumption

Although the United States requires a warning label on alcoholic beverages, alcohol-related deaths have risen steadily over the past two decades.

5 May 2026

WHO report shows measurable progress in reducing global hepatitis infections

Global efforts to combat viral hepatitis are delivering measurable progress in reducing infections and deaths, but the disease remains a major global health challenge, according to a new World Health Organization (WHO) report released today at the World Hepatitis Summit.

28 Apr 2026