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Pseudogene lncRNAs regulate cancer stem cell behavior and signaling

Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to therapy due to their innate capacity for self-renewal and differentiation.

11 Apr 2026

Dynamic AI models detect body tipping points to forecast disease before symptoms

The editorial, "Dynamics-driven medical big data mining: dynamic approaches to early disease forecasting and individualized care," published in Intelligent Medicine (February 2026, Volume 6, Issue 1), was written by Lu Wang (Tianjin Medical University), Han Lyu (Beijing Friendship Hospital, Capital Medical University), and Bin Sheng (Shanghai Jiao Tong University).

10 Apr 2026

Study maps DNA methylation changes driving MDS stem cell dysfunction

Published on April 01, 2026, in Volume 2, article number 19 of the journal Immunity & Inflammation, a collaborative team led by Prof. Cao at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, along with Dr. Liangding Hu at the Fifth Medical Center of Chinese PLA General Hospital, and Professors Qian Zhang and Yanmei Han at the National Key Laboratory of Immunity and Inflammation, Naval Medical University, has generated the first base-resolution DNA methylome of human MDS HSCs.

9 Apr 2026

OICR funds four Ontario teams to develop next-generation cancer therapies

Better cancer care depends on better treatment options. That's why the Ontario Institute for Cancer Research (OICR) is supporting four Ontario-based research teams working to develop the next generation of cancer therapies that are designed to be more effective at destroying tumors, have reduced side effects, and make cancer less likely to return.

9 Apr 2026

Never married adults face higher risk of developing cancer

Adults who have never been married face a significantly higher risk of developing cancer than those who have been married, according to a large U.S. study of more than 4 million cases.

8 Apr 2026

Clusterin inhibition offers new hope for treating cervical gastric-type adenocarcinoma

Gastric-type adenocarcinoma (GAS) is one of the most aggressive non-human papillomavirus (HPV)-associated cervical adenocarcinomas and remains especially difficult to diagnose and treat.

8 Apr 2026

Study reveals how hyperdiploidy creates rare pre-leukemic clones in children

B-cell acute lymphoblastic leukemia is the most common form of childhood cancer. In this type of cancer, which affects blood cells, one of the most common abnormalities is the presence of cells with an excess of chromosomes (hyperdiploidy), a condition that leads to chromosomal instability.

8 Apr 2026

Blocking nitric oxide suppresses tumor growth in aggressive pediatric neuroblastoma

The tumor begins before birth. Somewhere in the developing fetus, neural crest cells that should have matured into adrenal tissue or sympathetic ganglia take a wrong turn, and a child is born harboring a malignancy that may not declare itself for months.

7 Apr 2026

Dual perspective AI model achieves high accuracy in early lung cancer diagnosis

Lung cancer remains the leading cause of cancer-related deaths worldwide, accounting for nearly one in five cancer deaths - around 1.8 million lives lost each year.

7 Apr 2026

Advances in nanomedicine improve anthelmintic drug delivery and effectiveness

Announcing a new article publication in BIO Integration. According to World Health Organization (WHO) reports, parasitic infections substantially affect the world's population and are responsible for more than 16 million annual deaths in developing countries.

2 Apr 2026

Study reveals CAR T approach for hard-to-treat solid tumors

Chimeric antigen receptor T-cell therapy - CAR T for short - has been a major advance in treating blood cancers like leukemia and lymphoma.

30 Mar 2026

Study links atrial fibrillation to poorer brain clearance and cognitive decline

Researchers found that people with atrial fibrillation had lower MRI-based glymphatic activity and poorer cognitive performance than healthy controls, with the greatest impairment seen in non-paroxysmal AF. In patients who underwent catheter ablation, glymphatic activity improved after sinus rhythm was restored, suggesting a possible link between heart rhythm, brain waste clearance, and cognition.

30 Mar 2026

Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

Researchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-linked chromatin changes and later amplifies tumour outgrowth after oncogenic mutation.

29 Mar 2026

Molecular test shows high sensitivity in detecting bile duct cancer

When patients develop a narrowing or blockage in the bile ducts – the tubes connecting the liver, gallbladder and intestines – physicians must determine whether the cause is cancer or a benign condition.

27 Mar 2026

Study reveals how inflammation disrupts lymph node structure in lymphoma

In aggressive lymphomas, inflammatory messengers reprogram the "conductors" of the immune system, causing lymph nodes structure to collapse.

26 Mar 2026

Obesity-driven organ enlargement may boost cancer risk

Scientists at City of Hope® and TGen (part of City of Hope) are the first to explain a major mechanism for why gaining excess weight increases your risk of cancer.

26 Mar 2026

Detailed cell atlas reveals earliest changes in prostate cancer

Prostate cancer affects one in five Australian men, making it the most common cancer in the country.

25 Mar 2026

iXCells Biotechnologies joins international collaboration to evaluate chemotherapeutic toxicity in human organoids

iXCells Biotechnologies ("iXCells"), a leading provider of human cell-based solutions and custom iPSC services, today announced it has entered an international collaboration with Rosebud Biosciences ("Rosebud"), Kantify, and Incite to evaluate off-target chemotherapeutic toxicities in patient-specific organoids.

From iXCells Biotechnologies 25 Mar 2026

Breast reduction surgery is linked to lower diabetes and heart risk

Findings suggest breast reduction surgery is associated with lower long-term diabetes and cardiovascular risks, enhancing women's metabolic health.

24 Mar 2026

New nanoparticle therapy overcomes T cell exhaustion in solid tumors

Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one day serve as a universal immunotherapy for cancers that form solid tumors, including common variants such as cancers of the breast, liver and colon.

18 Mar 2026