Monoclonal Antibody News and Research

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Monoclonal antibodies (MAbs) are produced from a single B cell clone and can bind to a single type of antigen binding site. MAbs are homogenous antibodies that cannot form lattices with monomeric proteins as they can bind to only a single epitope on the antigen. Developed in the 1970s, MAbs can be produced against any given substance. Thus they can be used to detect and purify any substance of interest. This has made MAbs a powerful tool of molecular biology, biochemistry, and medicine.

Researchers report promising results of potential reversal agent

In patients with acute coronary syndromes, coronary artery stenting, or a history of prior heart attacks, antiplatelet therapy can be lifesaving.

18 Mar 2019

Antibody-drug conjugate effectively targets surface protein in childhood neuroblastomas

Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells.

14 Mar 2019

CAR-T cell therapy could be on the horizon for patients with lupus

Researchers have developed a novel CAR-T cell therapy that can reduce B cell numbers known to cause the inflammatory responses in lupus.

7 Mar 2019

EAF4 module determines physicochemical, biophysical attributes of monoclonal antibodies

Postnova Analytics Inc. reports how its Electrical Asymmetrical Flow Field Flow Fractionation and Size Exclusion Chromatography modules have been used to determine the physicochemical and biophysical attributes of monoclonal antibodies.

From Postnova Analytics 6 Mar 2019

Study shows precision medicines could aid more breast cancer patients via RNA-targeting

When women or men receive the worrisome diagnosis of breast cancer, that news comes with an important piece of information, namely, whether their cancer is HER2-positive or HER2-negative.

8 Feb 2019

Immunotherapy drug found to be effective in patients with advanced Merkel cell carcinoma

A multi-center phase II clinical trial investigating pembrolizumab as a first-line and programmed cell death-1 therapy in patients with advanced Merkel cell carcinoma reports lasting tumor control, generally manageable side effects and improved overall survival.

8 Feb 2019

A new approach towards future treatment of diabetes

It is said that the eyes are the window to the soul, but they may also open the door for discovering new ways to achieve immune tolerance to transplanted islets in type 1 diabetes, according to research from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine.

3 Feb 2019

Investigational Ebola treatment found to be safe in adults

The investigational Ebola treatment mAb114 is safe, well-tolerated, and easy to administer, according to findings from an early-stage clinical trial published in The Lancet.

25 Jan 2019

Researchers identify marker protein that offers both diagnostic and therapeutic function

Of all gastrointestinal cancers, pancreatic cancer is one of the most aggressive. Because of this, it has a very low 5-year survival rate of just 5% and a median survival time below 6 months. Additionally, treatment is difficult, with only surgery shown to provide a cure. However, the vast majority of patients have tumors that cannot be removed surgically or their cancer is too advanced or spread too far to be treatable.

24 Jan 2019

Sartorius Stedim Biotech launches NBE product characterization service

Sartorius Stedim Biotech, a leading international supplier for the biopharmaceutical industry, announced the launch of services for new biological entities, called NBE Product Characterization.

From Sartorius 24 Jan 2019

Lab-Scale Clarification of Mammalian Cell Cultures Expressing Recombinant Antibodies

Tina Stoschek and Marcus Gerlach discuss maximizing mAb generation using lab-scale clarification of cell cultures expressing recombinant antibodies.

From Sartorius 23 Jan 2019

Monoclonal antibody pembrolizumab prolongs survival in patients with squamous cell carcinoma

Squamous cell carcinoma is one of the most common cancers of the skin and mucosa. Treatment options for the advanced stage have been very limited for patients with tumors of the head and neck, i.e. in the mouth, the pharynx or the larynx: If recurrences or metastases occur during or after platinum-based chemotherapy, the disease is generally considered incurable.

18 Jan 2019

High-performing MS device reaches new level in characterizing protein impurities

In response to current regulatory guidance a Mass Spectrometry-based Host Cell Protein detection approach with faster, more accurate and wider-ranging detection is essential.

10 Jan 2019

FDA approves initiation of first-in-human trial of DNA-encoded monoclonal antibody

The Wistar Institute, along with partners Penn Medicine and Inovio Pharmaceuticals, Inc., announce that the FDA has approved the initiation of a first-in-human clinical trial investigating the safety and tolerability of a novel synthetic DNA-encoded monoclonal antibody therapeutic technology for the prevention of Zika virus infection.

9 Jan 2019

IONTAS founder and pioneer in phage display technology attends Nobel Prize Award Ceremony

Dr. John McCafferty celebrates the success of phage display technology with Nobel Prize in Chemistry Laureates.

From FairJourney Biologics 12 Dec 2018

New antibody can reduce swelling attacks in patients with hereditary angioedema

Patients with hereditary angioedema experience recurrent and sometimes life-threatening swelling attacks. Researchers from Charité - Universitätsmedizin Berlin have tested an antibody capable of reducing the frequency of these swelling attacks by more than 90 percent.

28 Nov 2018

New method could improve outcome of leukemia patients receiving stem-cell transplants

Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients' healthy tissue - often with fatal consequences.

28 Nov 2018

NIH-funded study finds how hantaviruses infect the lungs

A human protein associated with asthma is key to how hantaviruses infect the lungs and sometimes cause a life-threatening pulmonary condition known as hantavirus pulmonary syndrome, according to researchers supported by the National Institutes of Health.

26 Nov 2018

Vanderbilt researchers isolate antibody that can neutralize West Nile virus

Researchers at Vanderbilt University Medical Center and colleagues have isolated a human monoclonal antibody that can "neutralize" the West Nile virus and potentially prevent a leading cause of viral encephalitis (brain inflammation) in the United States.

21 Nov 2018

Study reveals impact of residual inflammatory risk on clinical outcomes after PCI

Patients who have persistently high levels of inflammation following percutaneous coronary intervention for coronary artery disease are significantly more likely to die from any cause or to have a heart attack within a year, according to a study of 7,026 patients published in the European Heart Journal.

19 Nov 2018

Monoclonal Antibody News and Research

Further Reading

Researchers report promising results of potential reversal agent

Antibody-drug conjugate effectively targets surface protein in childhood neuroblastomas

CAR-T cell therapy could be on the horizon for patients with lupus

EAF4 module determines physicochemical, biophysical attributes of monoclonal antibodies

Study shows precision medicines could aid more breast cancer patients via RNA-targeting

Immunotherapy drug found to be effective in patients with advanced Merkel cell carcinoma

A new approach towards future treatment of diabetes

Investigational Ebola treatment found to be safe in adults

Researchers identify marker protein that offers both diagnostic and therapeutic function

Sartorius Stedim Biotech launches NBE product characterization service

Lab-Scale Clarification of Mammalian Cell Cultures Expressing Recombinant Antibodies

Monoclonal antibody pembrolizumab prolongs survival in patients with squamous cell carcinoma

High-performing MS device reaches new level in characterizing protein impurities

FDA approves initiation of first-in-human trial of DNA-encoded monoclonal antibody

IONTAS founder and pioneer in phage display technology attends Nobel Prize Award Ceremony

New antibody can reduce swelling attacks in patients with hereditary angioedema

New method could improve outcome of leukemia patients receiving stem-cell transplants

NIH-funded study finds how hantaviruses infect the lungs

Vanderbilt researchers isolate antibody that can neutralize West Nile virus

Study reveals impact of residual inflammatory risk on clinical outcomes after PCI

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