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Groundbreaking trial finds levofloxacin effective against multidrug-resistant TB

A clinical trial published in the New England Journal of Medicine showed that the oral antibiotic levofloxacin taken once-daily for six months substantially reduced the risk of developing drug-resistant tuberculosis (TB), and almost halved adults' and children's risk of developing multidrug-resistant TB.

15 Jan 2025

Hormonal shifts in menopause redefine women’s microbiome and risks

Research explores how menopause-induced hormonal shifts affect the microbiome, influencing oral, gut, and urogenital health, and highlights the potential of personalized interventions to enhance well-being.

15 Jan 2025

Study examines how often acne recurs after isotretinoin treatment

Isotretinoin, commonly referred to as Accutane, is the only approved medical treatment capable of inducing long-term remission of severe acne.

15 Jan 2025

Study explores cancer risks of hormonal contraceptives

Many women worry hormonal contraceptives have dangerous side-effects including increased cancer risk. But this perception is often out of proportion with the actual risks.

15 Jan 2025

Pheno Therapeutics granted clinical trial authorization for lead multiple sclerosis therapeutic candidate PTD802

Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics for the treatment of neurological diseases, announced today it has received clinical trial authorization (CTA) from the UK’s MHRA (Medicines and Healthcare products Regulatory Agency) for its lead candidate, PTD802.

From Pheno Therapeutics 15 Jan 2025

Pharmacokinetics of berberine and astragaloside IV in normal and diabetic rats

Announcing a new publication for Acta Materia Medica journal. The UPLC-QqQ-MS/MS method was established, validated, and used for the simultaneous detection of berberine (BBR), astragaloside IV (AST), and the main metabolites to demonstrate the comparative pharmacokinetics of BBR and AST in normal and T2DM rats.

15 Jan 2025

The role of saliva in Hemophilia A coagulation

A recent study led by MedUni Vienna provides new insights into the mechanisms of coagulation in persons with haemophilia A, the most common form of haemophilia. The research team was able to show that saliva contains special vesicles that trigger rapid coagulation of the blood of haemophilic patients. The results, which were recently published in the renowned scientific journal Blood, contribute significantly to a better understanding of the disease.

15 Jan 2025

Australia sees a decline in type 2 diabetes, but disparities persist

Type 2 diabetes incidence in Australia decreased from 2010 to 2019 overall but rose among younger men and specific ethnic groups, highlighting persistent disparities.

13 Jan 2025

HIV drug access remains a major challenge despite promising trial results

Promising new drugs to prevent and treat HIV have the potential to transform the response to the disease. But getting these drugs to those who need it most will be critical, says Beatriz Grinsztejn, president of the International AIDS Society.

10 Jan 2025

A large-scale tongue cancer organoid library for precision oncology

Oral cancer is an increasingly prevalent disease worldwide, with over 300,000 new cases diagnosed each year. Among oral cancers, tongue cancer (TC) is the most common type and often carries a poor prognosis. Surgery combined with chemoradiotherapy is one of the main lines of treatment for high-risk cases of TC.

9 Jan 2025

Oral medications less effective than insulin for preventing large babies in gestational diabetes study

A study comparing oral glucose-lowering agents to insulin for gestational diabetes found no non-inferiority in preventing large-for-gestational-age infants.

9 Jan 2025

Could camembert cheese hold the key to better memory?

Myristamide enhances cognitive function and BDNF in mice, indicating Camembert cheese's potential in combating cognitive decline and supporting brain health.

9 Jan 2025

3D printed bone scaffolds successfully used to rebuild jawbone

Clinicians have successfully used custom-made 3D printed bone scaffolds, printed on-site at The University of Queensland, to rebuild part of a man's jawbone.

8 Jan 2025

Extended Paxlovid courses show mixed results for long COVID symptoms

A study indicates that longer Paxlovid treatments could improve long COVID symptoms in some patients, highlighting the need for tailored antiviral strategies.

8 Jan 2025

AI-based tool identifies subtypes of Type 2 diabetes using glucose monitors

Diabetes has long been lumped into two categories - Type 1, which often appears in childhood, or Type 2, which is associated with obesity and typically develops later in life. But scientists have learned that not all patients with Type 2 diabetes are the same, with some patients varying in body weight, age of onset and other characteristics.

7 Jan 2025

Hidden culprit: Human metapneumovirus identified in severe adult pneumonia case

Severe pneumonia caused by human metapneumovirus in an immunocompetent adult highlights diagnostic challenges and underscores the need for rapid molecular diagnostics to improve outcomes.

6 Jan 2025

Early results of doxy PEP rollout show mixed impact on STIs

As health care services begin offering doxycycline to prevent bacterial sexually transmitted infections (STIs), real-world evidence demonstrates that the postexposure strategy, called doxy PEP, is reducing the rate of syphilis and chlamydia, but has had little to no effect on gonorrhea and needs close monitoring for signals of antibiotic resistance.

6 Jan 2025