Carcinoma News and Research

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Carcinoma is cancer that begins in the skin or in tissues that line or cover internal organs.

Study may lead to more refined approaches for head and neck cancers

By targeting an enzyme that plays a key role in head and neck cancer cells, researchers from the UCLA School of Dentistry were able to significantly slow the growth and spread of tumors in mice and enhance the effectiveness of an immunotherapy to which these types of cancers often become resistant.

24 Mar 2021

YAP inhibitors could facilitate targeted treatment of basal-like breast cancer

Targeted treatment of basal-like breast cancer could be facilitated by YAP inhibitors in the future. As reported by an MDC team headed by Walter Birchmeier in the scientific journal Cancer Research, this type of cancer requires the support of the YAP protein to stimulate the growth of cancer stem cells.

22 Mar 2021

Study characterizes shifting neoantigen burden between primary and metastatic tumors within HNSCC

Oncotarget published "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma" which reported that prior work has characterized changes in the mutation burden between primary and recurrent tumors; however, little work has characterized the changes in neoantigen evolution.

18 Mar 2021

Newly identified drugs can help treat oral and esophageal carcinomas

Discovering and treating tumors before they spread throughout the body is key for cancer patients to achieve positive outcomes. When tumor cells spread, which is known as metastasis, they can take over other organs and lead to death.

17 Mar 2021

Chromatin-regulating enzyme found to be a key driver of common lung cancer

A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer.

15 Mar 2021

Cannabis compound inhibits SARS-CoV-2 replication in human lung cells

Researchers in the United States have conducted a study showing that a cannabis plant compound inhibited infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human lung cells.

14 Mar 2021

Studies reveal how kidney tumors' microenvironments change in response to immunotherapy

In the last two decades, immunotherapy has emerged as a leading treatment for advanced renal carcinoma cancer (more commonly known as kidney cancer).

11 Mar 2021

Study examines m6A regulators and m6A-related genes through integrated bioinformatic analysis

Announcing a new article publication for BIO Integration journal. In this article the authors Jingdun Xie, Zhenhua Qi, Xiaolin Luo, Fang Yan, Wei Xing, Weian Zeng, Dongtai Chen and Qiang Li; from Sun Yat-sen University, Guangzhou, Guangdong, China discuss integration analysis of m6A regulators and m6A-related genes in hepatocellular carcinoma (HCC).

10 Mar 2021

New tumor-penetrating therapy may improve outcomes in patients with pancreatic cancer

Every 12 minutes, someone in the United States dies of pancreatic cancer, which is often diagnosed late, spreads rapidly and has a five-year survival rate at approximately 10 percent.

9 Mar 2021

Researchers establish organoid culture models from prostate tumor biopsies

Scientists at Urology Research Laboratory of the Department for BioMedical Research, University of Bern and Urology Department of the Inselspital of Bern, have established organoid culture models from prostate tumor biopsies.

8 Mar 2021

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria.

5 Mar 2021

Cell surface marker CD47 may allow early diagnosis of severe COVID-19

A new study reports the potential of the cell surface marker, CD47, as a biomarker for hyperinflammation, a characteristic feature of severe COVID-19.

4 Mar 2021

Novel dual-targeting drug could become a next-generation treatment for EBV-related cancers

A Hong Kong Baptist University-led research team has developed a novel drug which has the potential to become a next-generation treatment for cancers associated with Epstein-Barr virus (EBV).

2 Mar 2021

Study findings help explain the diversity of cancers in different Li-Fraumeni patients

The most frequently mutated gene in human cancers is called p53. Patients with Li-Fraumeni syndrome, which is a rare disorder that increases the risk of developing several types of cancer, often have an increased risk to develop cancers at early ages if they inherit p53 mutations.

23 Feb 2021

Study shows how m6A regulators influence metabolic heterogeneity of hepatocellular carcinoma

Cancer cells acquire growth advantages over normal cells in myriad ways. Changes in cell programming allow these cells to grow in an uncontrolled fashion, thereby forming the cancer mass.

23 Feb 2021

Study could lead to new strategies to prevent various cancers

Chronic inflammation drives the development of various cancers, including those of the skin, colon and pancreas. Investigators at Massachusetts General Hospital (MGH) who previously demonstrated high expression levels of an immune molecule called interleukin-33 (IL-33) during cancer-promoting inflammation have now uncovered the details behind the molecule's effects.

22 Feb 2021

Xenograft model for invasive lobular carcinoma simulates tumor with high accuracy

Invasive lobular carcinoma (ILC) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast.

22 Feb 2021

Gastroesophageal reflux disease is linked with higher risks of larynx and esophageal cancers

Results from a large prospective study indicate that gastroesophageal reflux disease (GERD), which also causes heartburn symptoms, is linked with higher risks of various cancers of the larynx (or voice box) and esophagus.

22 Feb 2021

Molecular imaging can predict response to novel metastatic breast cancer treatment

Molecular imaging can successfully predict response to a novel treatment for ER-positive, HER2-negative metastatic breast cancer patients who are resistant to hormonal therapy.

17 Feb 2021

Study: Targeted therapy prolongs survival in patients with advanced bladder cancer

In a new study led by researchers at Yale Cancer Center, the drug enfortumab vedotin (EV) significantly prolonged survival as compared with standard chemotherapy in patients with locally advanced or metastatic urothelial carcinoma or bladder cancer, who had previously received platinum-based treatment and a PD-1–PD-L1 inhibitor.

15 Feb 2021

Carcinoma News and Research

Further Reading

Study may lead to more refined approaches for head and neck cancers

YAP inhibitors could facilitate targeted treatment of basal-like breast cancer

Study characterizes shifting neoantigen burden between primary and metastatic tumors within HNSCC

Newly identified drugs can help treat oral and esophageal carcinomas

Chromatin-regulating enzyme found to be a key driver of common lung cancer

Cannabis compound inhibits SARS-CoV-2 replication in human lung cells

Studies reveal how kidney tumors' microenvironments change in response to immunotherapy

Study examines m6A regulators and m6A-related genes through integrated bioinformatic analysis

New tumor-penetrating therapy may improve outcomes in patients with pancreatic cancer

Researchers establish organoid culture models from prostate tumor biopsies

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Cell surface marker CD47 may allow early diagnosis of severe COVID-19

Novel dual-targeting drug could become a next-generation treatment for EBV-related cancers

Study findings help explain the diversity of cancers in different Li-Fraumeni patients

Study shows how m6A regulators influence metabolic heterogeneity of hepatocellular carcinoma

Study could lead to new strategies to prevent various cancers

Xenograft model for invasive lobular carcinoma simulates tumor with high accuracy

Gastroesophageal reflux disease is linked with higher risks of larynx and esophageal cancers

Molecular imaging can predict response to novel metastatic breast cancer treatment

Study: Targeted therapy prolongs survival in patients with advanced bladder cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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