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Epigallocatechin gallate can shrink cancerous tumours

A compound found in green tea could be a weapon in treatments for tackling cancer, according to newly-published research at the University of Strathclyde in Glasgow, Scotland.

23 Aug 2012

Laminin-111 protein therapy could treat Duchenne muscular dystrophy

A novel treatment in development at the University of Nevada School of Medicine for the most common form of muscular dystrophy is advancing towards human trials with a $308,000 boost from the Muscular Dystrophy Association.

23 Aug 2012

TREM-1 gene disrupts inflammatory process implicated in liver cancer

Researchers at the Georgia Health Sciences University Cancer Center have identified a gene that disrupts the inflammatory process implicated in liver cancer.

23 Aug 2012

RNA switches can better equip and regulate viruses for many therapeutic applications

Numerous viruses are used in the service of science today. They serve as gene taxis to transfer therapeutic genes into body cells or as therapeutic viruses targeted to infect and destroy cancer cells. For such applications, the viruses are often equipped with additional genes, such as for immune mediators or for proteins inducing programmed cell death. However, these gene products can harm the body if they are released at the wrong moment or at excessive levels.

22 Aug 2012

Researchers report how Alzheimer's protein deposits disrupt signalling between nerve cells

How abnormal protein deposits in the brains of Alzheimer's patients disrupt the signalling between nerve cells has now been reported by researchers in Bochum and Munich, led by Dr. Thorsten M-ller from the Medizinisches Proteom-Center of the Ruhr-Universit-t, in the journal Molecular and Cellular Proteomics. They varied the amount of APP protein and related proteins associated with Alzheimer's disease in cell cultures, and then analysed how this manipulation affected other proteins in the cell.

22 Aug 2012

Coronary artery calcium tool proves effective in detecting risk of cardiovascular disease

Heart calcium scans are far superior to other assessment tools in predicting the development of cardiovascular disease in individuals currently classified at intermediate risk by their doctors, according to researchers at Wake Forest Baptist Medical Center.

22 Aug 2012

Mof protein plays a key role in epigenetics of stem cells

How do stem cells preserve their ability to become any type of cell in the body? And how do they "decide" to give up that magical state and start specializing? If researchers could answer these questions, our ability to harness stem cells to treat disease could explode. Now, a University of Michigan Medical School team has published a key discovery that could help that goal become reality.

22 Aug 2012

Study identifies how genetic mutations in the nervous system cause Duane Syndrome

A research team from King's College London and the University of Exeter Medical School has identified how a genetic mutation acts during the development of nerves responsible for controlling eye muscles, resulting in movement disorders such as Duane Syndrome, a form of squint.

22 Aug 2012

NIAID announces 14 grants for basic research to identify new HIV vaccine approaches

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded 14 grants totaling $7.8 million in first-year funding for basic research to identify new approaches for designing a safe and effective HIV vaccine.

22 Aug 2012

Chemists develop new lab test to examine how DNA damage disrupts protein synthesis

Transcription is a cellular process by which genetic information from DNA is copied to messenger RNA for protein production. But anticancer drugs and environmental chemicals can sometimes interrupt this flow of genetic information by causing modifications in DNA.

22 Aug 2012

Healthcare announces important changes to the U.S. product label for Optison

GE Healthcare today announced important changes to the U.S. product label for Optison (Perflutren Protein-Type A Microspheres Injectable Suspension, USP), a contrast agent that may improve the visualization of the left ventricular border - an area of the heart that is critical to see in order to diagnose certain heart diseases such as hypertrophic cardiomyopathy.

22 Aug 2012

Investigators discover biological explanation for why low levels of oxygen advance SMA symptoms

Investigators at Nationwide Children's Hospital may have discovered a biological explanation for why low levels of oxygen advance spinal muscular atrophy (SMA) symptoms and why breathing treatments help SMA patients live longer. The findings appear in Human Molecular Genetics.

22 Aug 2012

Study highlights Nek9 protein as decisive factor in cell division

A study by the Institute for Research in Biomedicine (IRB Barcelona) and the Center for Genomic Regulation (acronym in Catalan CRG) highlights the protein Nek9 as a decisive factor in cell division, a fundamental process for both the development of an organism and tissue maintenance.

22 Aug 2012

HDL cholesterol benefits reduced with high C-reactive protein

The cardioprotective effects of high-density lipoprotein cholesterol are compromised in the presence of elevated high-sensitivity C-reactive protein, report researchers.

21 Aug 2012

Genetic key to severe malaria resistance uncovered

Researchers have identified two genetic variants linked with human resistance to severe malaria.

21 Aug 2012

New silicon chips help identify patients with lupus

Researchers at the Stanford University School of Medicine and Intel Corp. have collaborated to synthesize and study a grid-like array of short pieces of a disease-associated protein on silicon chips normally used in computer microprocessors.

21 Aug 2012

Healthy brown-bag lunch can combat obesity in school children

As the new school year approaches, parents have to decide what their children will eat for lunch. Should they help the kids brown bag it or remember to take their lunch money? While this might not seem to be a major issue, it is - because the importance of school lunch rises with the rates of childhood obesity, say University of Alabama at Birmingham experts.

21 Aug 2012

MitoTarget Project and neurodegenerative diseases: an interview with Rebecca Pruss, Ph.D., CSO of Trophos

The MitoTarget Project was a project funded by the European Commission, under their FP7 programme. It was funding for a call published in 2007.

21 Aug 2012

Study identifies mode of death of cone photoreceptor cells in animal model of RP

Research conducted at the Angiogenesis Laboratory at Massachusetts Eye and Ear Infirmary, has for the first time, identified the mode of death of cone photoreceptor cells in an animal model of retinitis pigmentosa (RP).

21 Aug 2012

Study utilizes integrative approach to probe biology of bipolar disorder

The more that we understand the brain, the more complex it becomes. The same can be said about the genetics and neurobiology of psychiatric disorders. For "Mendelian" disorders, like Huntington disease, mutation of a single gene predictably produces a single clinical disorder, following relatively simple genetic principals. Compared to Mendelian disorders, understanding bipolar disorder has been extremely challenging. Its biology is not well understood and its genetics are complex.

21 Aug 2012

G Protein News and Research

Epigallocatechin gallate can shrink cancerous tumours

Laminin-111 protein therapy could treat Duchenne muscular dystrophy

TREM-1 gene disrupts inflammatory process implicated in liver cancer

RNA switches can better equip and regulate viruses for many therapeutic applications

Researchers report how Alzheimer's protein deposits disrupt signalling between nerve cells

Coronary artery calcium tool proves effective in detecting risk of cardiovascular disease

Mof protein plays a key role in epigenetics of stem cells

Study identifies how genetic mutations in the nervous system cause Duane Syndrome

NIAID announces 14 grants for basic research to identify new HIV vaccine approaches

Chemists develop new lab test to examine how DNA damage disrupts protein synthesis

Healthcare announces important changes to the U.S. product label for Optison

Investigators discover biological explanation for why low levels of oxygen advance SMA symptoms

Study highlights Nek9 protein as decisive factor in cell division

HDL cholesterol benefits reduced with high C-reactive protein

Genetic key to severe malaria resistance uncovered

New silicon chips help identify patients with lupus

Healthy brown-bag lunch can combat obesity in school children

MitoTarget Project and neurodegenerative diseases: an interview with Rebecca Pruss, Ph.D., CSO of Trophos

Study identifies mode of death of cone photoreceptor cells in animal model of RP

Study utilizes integrative approach to probe biology of bipolar disorder

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