Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Specific gut microbes have the capacity to affect normal skeletal growth and maturation

Microbes are often seen as pathogens that cause disease, but the picture is actually more complex than that limited view.

28 Jan 2020

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

American and British teams led by Drs Kohn (University of California, Los Angeles), Malech (NIH), Williams (Boston Children's) and Trasher (Great Ormond Street Institute of Child Health) published yesterday in Nature Medicine the conclusive results of a gene therapy trial conducted in the United States and Great Britain in 9 patients with X-linked Chronic Septic Granulomatosis (X-CGD), a rare and severe immune dysfunction. Six of them are free of treatment for complications generated by the disease.

28 Jan 2020

Novel nanoparticle eats away portions of plaques that cause heart attacks

Michigan State University and Stanford University scientists have invented a nanoparticle that eats away - from the inside out - portions of plaques that cause heart attacks.

27 Jan 2020

T. gondii parasite employs a sophisticated manipulation to suppress host's immune response

Toxoplasma gondii is best known as the parasite that may lurk in a cat's litter box. Nearly a third of the world's population is believed to live with a chronic Toxoplasma infection.

24 Jan 2020

Iron overload, variant gene and malaria resistance linked in African study

A new study shows that a rare genetic mutation giving rise to a variant of the TP53 gene called P47S causes several linked biological processes.

24 Jan 2020

Being exposed to diesel exhaust particles raises pneumococcal disease risk

Air pollution is a long-standing global problem, which is responsible for 7 million deaths each year, with 7 percent of these attributed to pneumonia. A new study highlights how air pollution affects the airways making the body susceptible to developing the pneumococcal disease.

23 Jan 2020

Immune system cells facilitate the invasive capacity of glioblastoma

In a study published in Brain Communications, a new Open Access publication of the well-known journal Brain, the team led by Carlos Barcia, researcher at Institut de Neurociències of the Universitat Autònoma de Barcelona, analyzed the role of immune cells in the expansion of glioblastoma, the most aggressive brain tumor.

23 Jan 2020

New method reveals how giant viruses infect amoeba

Host cells infected with giant viruses behave in a unique manner. To gain deeper insight into the infection mechanism of giant viruses, scientists at Tokyo University of Science developed a specialized algorithm that can track the movement of host cells.

23 Jan 2020

Arginine depletion could form the basis for potential rheumatoid arthritis therapies

A group from the MedUni Vienna has identified a role for the endogenous amino acid arginine in the growth of osteoclasts in rheumatoid arthritis.

23 Jan 2020

Study shows how gene therapy may help protect against vision loss in multiple sclerosis

New research by Dorothy P. Schafer, PhD, at the University of Massachusetts Medical School, reveals the molecular process in which synaptic connections in the brain are damaged in multiple sclerosis and how this contributes to neurodegenerative symptoms.

21 Jan 2020

Discovery of potent immune cell that can destroy multiple types of cancer

The immune system is the body’s defense against harmful pathogens that may enter the body. Immune cells, such as white blood cells and macrophages work hand in hand to fight off disease-causing microorganisms, including cancer.

21 Jan 2020

Study reveals new mechanism involved in the pathogenesis of IBD

Inflammatory bowel disease is a category of refractory inflammatory disease, of which ulcerative colitis and Crohn's disease are the main types.

21 Jan 2020

Estrogen plays a role in expansion of liver metastases in non-sex-specific cancers

It is known that the tumor microenvironment plays an important role in the progression of cancer. But could estrogen present in this microenvironment facilitate the growth of liver metastases in women affected by colon, pancreatic and lung cancers?

17 Jan 2020

Study shows how cancer-causing genes promote metastasis

Cancer-promoting genes MYC and TWIST1 co-opt immune system cells to enable cancer cells to spread, but blocking a key step in this process can help prevent the disease from developing.

14 Jan 2020

Study provides insights into how viral infection can continue to affect immunity

The strength of the immune system in response to respiratory infections is constantly changing, depending on the history of previous, unrelated infections, according to new research from the Crick.

From The Francis Crick Institute 14 Jan 2020

Mice study offers new insight on irritable bowel syndrome

Sometimes the end of an intestinal infection is just the beginning of more misery. Of those who contract traveler's diarrhea, for example, an unlucky few go on to develop irritable bowel syndrome (IBS), a chronic inflammation of the intestinal tract.

12 Jan 2020

Rejuvenating the BCG Vaccine

A new primate study published in the journal Nature in January 2020, reports that the almost century-old BCG vaccine against tuberculosis, may be used differently to achieve better protection against lung tuberculosis. While more work remains to be carried out before the findings can be accepted as the basis for clinical practice, they are extremely promising in the fight against this killer.

10 Jan 2020

Pathios appoints Stuart Hughes as CEO and announces US$8.8M Series A financing round

Pathios Therapeutics Limited, an innovative biotech company focused on the development of first-in-class therapies for autoimmune diseases and cancer, today announced a US$8.8M Series A financing round with leading international healthcare investors Canaan and Australia’s Medical Research Commercialization Fund managed by Brandon Capital.

9 Jan 2020

Persistent TB infection of macrophages puts the brakes on immune engines, study shows

Scientists from Trinity College Dublin have discovered both how TB puts the brakes on our immune engines and how we can kick-start those engines back into gear - providing hope that improved treatment options could soon be on the horizon.

8 Jan 2020

Immune cells could help kill cancer cells, finds study

Researchers from UCL Cancer Institute have found that a subset of immune cells can kill cancer cells when activated.

8 Jan 2020

Macrophage News and Research

Further Reading

Specific gut microbes have the capacity to affect normal skeletal growth and maturation

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

Novel nanoparticle eats away portions of plaques that cause heart attacks

T. gondii parasite employs a sophisticated manipulation to suppress host's immune response

Iron overload, variant gene and malaria resistance linked in African study

Being exposed to diesel exhaust particles raises pneumococcal disease risk

Immune system cells facilitate the invasive capacity of glioblastoma

New method reveals how giant viruses infect amoeba

Arginine depletion could form the basis for potential rheumatoid arthritis therapies

Study shows how gene therapy may help protect against vision loss in multiple sclerosis

Discovery of potent immune cell that can destroy multiple types of cancer

Study reveals new mechanism involved in the pathogenesis of IBD

Estrogen plays a role in expansion of liver metastases in non-sex-specific cancers

Study shows how cancer-causing genes promote metastasis

Study provides insights into how viral infection can continue to affect immunity

Mice study offers new insight on irritable bowel syndrome

Rejuvenating the BCG Vaccine

Pathios appoints Stuart Hughes as CEO and announces US$8.8M Series A financing round

Persistent TB infection of macrophages puts the brakes on immune engines, study shows

Immune cells could help kill cancer cells, finds study

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