Efficacy News and Research

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Viral immunotherapy shows promise to treat pediatric brain tumors

A viral immunotherapy using a herpes virus to treat brain tumors has been shown to be safe and well-tolerated in a pediatric study from the University of Alabama at Birmingham and Children's of Alabama.

4 Jul 2018

New blood test can help determine the state of a person's internal clock

With a new blood test, researchers at the Charité - Universitätsmedizin Berlin can determine the state of the internal clock of a person. Once the internal rhythm of patient is known, drugs could be administered at particular times of day making them more effective and with fewer side effects than standard therapy.

2 Jul 2018

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

New Rekovelle analysis shows AMH is robust predictor of ovarian response to fertility treatment

Ferring Pharmaceuticals announced today a new analysis of data from the Phase 3 ESTHER-1 trial showing that natural variations in anti-Müllerian hormone levels during and between a woman's menstrual cycle have no clinically relevant impact on ovarian response when using AMH to dose Rekovelle for ovarian stimulation.

2 Jul 2018

Mathematical model assesses efficacy, cost-effectiveness of screening strategies for HCV

It is currently recommended in Europe that screening for hepatitis C virus should target people at high risk of infection.

2 Jul 2018

Psychedelics and their role in treatment of mental health disorders

Psychedelics such as LSD, magic mushrooms, mescaline etc. have garnered renewed interest in the scientific world because of the possible role they could play in mental health problems. Ketamine remains the only hallucinogen at present that is used clinically as an anesthetic agent. The others are all classified under banned drugs.

2 Jul 2018

Higher doses of rifampin kill more TB bacteria in sputum without increasing adverse effects

Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, killed more TB bacteria in sputum cultures, and the higher doses did so without increasing the adverse effects of treatment, according to a randomized controlled trial published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

29 Jun 2018

Review discusses complexity of immune-suppressive mechanisms in tumor milieu of cancers

Cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.

29 Jun 2018

Heroin could could help patients with narcolepsy

A new study has found that users of heroin have high levels of a brain chemical called hypocretin. This hypocretin leads to “wakefulness” among the users and understanding this could help patients with narcolepsy.

29 Jun 2018

Special training for teachers may mean big results for students with autism

Special training for teachers may mean big results for students with autism spectrum disorder, according to Florida State University and Emory University researchers.

28 Jun 2018

URI researchers working to develop novel medication to treat alcohol use disorder

Alcohol abuse is among the leading causes of preventable death in the United States, killing more than 88,000 people a year, according to the Centers for Disease Control.

28 Jun 2018

DNA methylation predicts survival outcome in patients with glioma

A new study has shown that survival rates among patients with glioma double if the tumor carries a methylated MGMT gene.

28 Jun 2018

Researchers examine whether taking a hallucinogen can curb cocaine use

Unlike with alcohol or nicotine, there is not a pharmacological option available to individuals addicted to cocaine to help them stop using the drug. However, researchers at the University of Alabama at Birmingham believe the tool to help individuals treat their addiction may very well exist.

28 Jun 2018

FDA approves cannabis based drug for severe form of epilepsy

The U.S. Food and Drug Administration (FDA) on the 25th of June 2018 approved Epidiolex oral solution that is essentially cannabidiol or the active component of marijuana or cannabis. As of now the drug is approved for use in two rare forms of epilepsy - Lennox-Gastaut syndrome and Dravet syndrome. The approval comes for individuals over two years of age.

28 Jun 2018

Cardiac specialists review benefits of 'prehabilitation' before heart surgery for older, frail patients

High risk, frail heart patients might derive benefits from "prehabilitation," a strategy designed to enhance the recovery process after heart surgery by maintaining or improving the patient's overall physical and mental status before surgery, according to a group of eminent cardiac specialists writing in the Canadian Journal of Cardiology.

27 Jun 2018

Researchers receive grant to evaluate efficacy of tobacco cessation methods

Researchers at The University of Kansas Cancer Center have received a five-year National Institutes of Health R0-1 grant to compare and evaluate the efficacy of optimized versus non-optimized tobacco cessation approaches for African American smokers.

27 Jun 2018

Study shows benefits, safety of long-lasting radionuclide therapy for patients with advanced NETs

A first-in-human study presented at the 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging demonstrates the benefits and safety of a new, long-lasting type of radionuclide therapy for patients with advanced, metastatic neuroendocrine tumors.

26 Jun 2018

Are wearable defibrillators a suitable alternative to surgically implanted devices?

Wearable defibrillators may be a safe and effective alternative to surgically implanted devices among children with ventricular arrythmias that increase the risk of sudden cardiac death, according to a new study.

26 Jun 2018

Novel theranostic agent designed for precise tumor diagnosis and therapy

A novel, intelligent theranostic agent for precise tumor diagnosis and therapy has been developed that remains as small molecules while circulating in the bloodstream, can then self-assemble into larger nanostructures in the tumor, and be activated by the tumor microenvironment for therapy guided by photoacoustic imaging.

26 Jun 2018

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

More than 60 percent of breast cancer cases involve defects in the same biochemical chain of events within cancer cells-- known as the PI3 kinase (PI3K) pathway--but efforts to develop therapies targeting this pathway have met with little success after hundreds of mostly failed clinical trials. And researchers still don't understand why.

26 Jun 2018

Efficacy News and Research

Viral immunotherapy shows promise to treat pediatric brain tumors

New blood test can help determine the state of a person's internal clock

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

New Rekovelle analysis shows AMH is robust predictor of ovarian response to fertility treatment

Mathematical model assesses efficacy, cost-effectiveness of screening strategies for HCV

Psychedelics and their role in treatment of mental health disorders

Higher doses of rifampin kill more TB bacteria in sputum without increasing adverse effects

Review discusses complexity of immune-suppressive mechanisms in tumor milieu of cancers

Heroin could could help patients with narcolepsy

Special training for teachers may mean big results for students with autism

URI researchers working to develop novel medication to treat alcohol use disorder

DNA methylation predicts survival outcome in patients with glioma

Researchers examine whether taking a hallucinogen can curb cocaine use

FDA approves cannabis based drug for severe form of epilepsy

Cardiac specialists review benefits of 'prehabilitation' before heart surgery for older, frail patients

Researchers receive grant to evaluate efficacy of tobacco cessation methods

Study shows benefits, safety of long-lasting radionuclide therapy for patients with advanced NETs

Are wearable defibrillators a suitable alternative to surgically implanted devices?

Novel theranostic agent designed for precise tumor diagnosis and therapy

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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