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Tissue-mimicking hydrogels drive cell reprogramming via matrix remodeling

The mechanical properties of tissue matrix are crucial for maintaining cell health and function. With aging, tissue matrix loses its mechanical integrity and exhibits altered biophysical properties, which are closely associated with various diseases including neurodegenerative diseases and cancers.

30 Sep 2025

Scientists map step-by-step activation of brain receptors

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, know that even slight changes in their activity level can mean the difference between normal function and serious neurological disorders.

24 Sep 2025

Patented antibacterial polymer technology prevents secondary cavities

The Basic to Breakthrough series chronicles how investments from the Department of Energy's (DOE) Office of Science at our National Laboratories have led to new technologies that are changing our world.

22 Sep 2025

Digital twin of lung cancer cell offers new insights into tumor growth and treatment

An enhanced computer model is now helping to provide fresh insights into cancer-cell growth and how it can be stopped. The digital cell model represents another step towards individualized cancer treatment.

18 Sep 2025

UCL launches landmark trial of Alzheimer’s blood test

A major UCL-led clinical trial, aiming to transform the diagnosis of Alzheimer's disease through a simple blood test, is now welcoming its first participants who will be recruited via memory clinics across the UK.

11 Sep 2025

Citrus flavonoid hesperidin lowers oxidative damage in cell experiments

Researchers tested hesperidin extracted from citrus peels and found it reduced inflammatory cytokines and oxidative stress markers in cultured immune cells. The findings highlight hesperidin’s strong in vitro anti-inflammatory and antioxidant potential, warranting further in vivo research.

11 Sep 2025

Axxam and B'SYS partner to expand access to validated ion channel cell lines for high-throughput electrophysiology

Axxam S.p.A., a premier provider of integrated early drug discovery services, and B'SYS GmbH, a specialist in ion channel biology, are pleased to announce a strategic collaboration focused on enabling access to validated ion channel cell lines for hit and lead identification through high-throughput electrophysiological screening.

From Axxam S.p.A 8 Sep 2025

Neutrophil peptide found to trigger dangerous heart arrhythmias

Following injury from a heart attack, immune cells called neutrophils release a peptide that punctures stressed heart cells and destabilizes their electrical activity.

4 Sep 2025

Rose petal-inspired sensors revolutionize wearable sweat monitoring

Wearable sensors can help prevent critical health issues by continuously monitoring physiological factors in real time.

28 Aug 2025

Synthetic Psychedelics: A Growing Public Health Concern

In this interview, Jonathan Ferguson discusses how knowledge of an emerging public health concern identified at Pittcon 2024 has evolved a year on.

From Pittcon 26 Aug 2025

Innovative cryo-microscopy offers precise views of rapid cell activity

Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a formidable task.

25 Aug 2025

How a single gene reshapes pain perception through polyamine signaling

Researchers have identified SLC45A4 as a neuronal polyamine transporter genetically linked to human chronic pain. Loss of this gene in mice disrupts polyamine balance, alters spinal GABA levels, and reduces heat and tonic pain sensitivity.

24 Aug 2025

New method enables comprehensive analysis of metabolites in biological samples

Researchers from the McCullagh Group in Oxford University's Department of Chemistry have published an innovative method in Nature Protocols today (22 August) that provides comprehensive analysis of metabolites found in cells, tissues and biofluids.

22 Aug 2025

University of Vienna team develops method to measure molecular charges

An international research team led by the University of Vienna has succeeded in developing a new method to directly measure partial charges in molecules. The results, now published in Nature, provide new insights into molecular interactions and offer potential applications in drug development and materials science.

22 Aug 2025