Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

Biliary epithelial cells found to actively prevent liver fibrosis development

Many liver diseases share a common characteristic: fibrosis, that is, the progressive accumulation of scarring in the liver tissue.

28 Apr 2026

Modeling the synergy of maternal screening and newborn HBV vaccination

Hepatitis B virus (HBV) infection acquired at birth or during early infancy can lead to lifelong health complications, including chronic liver disease. Despite longstanding recommendations for prenatal screening, an estimated 12% to 16% of pregnant individuals in the US are not screened for hepatitis B. This gap leaves a portion of newborns at risk for undetected exposure.

28 Apr 2026

Advanced heart, kidney and metabolic disease linked to higher cancer risk

People with advanced heart, kidney and metabolic disease may face a higher risk of developing cancer, according to new research published today in the American Heart Association's peer-reviewed scientific journal Circulation: Population Health and Outcomes.

27 Apr 2026

Study identifies key risk factors driving MASLD across populations

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32% of the US adult population.

23 Apr 2026

Specific intestinal fungi play role in the pathogenesis of MASLD and cardiovascular disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for cardiovascular disease (CVD). While gut bacteria have been linked to CVD, the role of intestinal fungi in subclinical coronary atherosclerosis (SCA) remains unclear.

23 Apr 2026

Microplastics in the liver may drive global liver disease rates

There is considerable evidence that microplastics and nanoplastics are present in the livers of humans, and wild animal populations on land and in the ocean.

23 Apr 2026

Paxlovid speeds recovery but does not reduce severe COVID outcomes in vaccinated adults

Paxlovid (nirmatrelvir-ritonavir) does not reduce hospital admissions or deaths in vaccinated adults at higher risk of severe COVID-19, despite helping them recover faster, according to results from two national trials published today in the New England Journal of Medicine.

22 Apr 2026

Tirzepatide vs. semaglutide: Study compares cost and health outcomes in obesity

In a US societal-perspective lifetime simulation based on SURMOUNT-5 data, tirzepatide was projected to deliver lower total costs and better health outcomes than semaglutide for adults with obesity or overweight without type 2 diabetes.

22 Apr 2026

Immune cell interactions drive liver inflammation and fibrosis

When the liver is injured - for example, due to bile accumulation - immune cells become activated. In mouse experiments, the Würzburg team observed that certain immune cells undergo functional changes in response to liver damage, adopting a highly pro-inflammatory state.

21 Apr 2026

Eating oranges daily may shift lipid patterns in fatty liver disease

A 4-week trial on 'Navelina' oranges shows potential effects on lipid metabolism in fatty liver disease, revealing intriguing but non-significant patterns.

20 Apr 2026

AGA update calls for better surveillance of hepatocellular carcinoma

A new update from the American Gastroenterological Association (AGA) urges stronger prevention efforts and better early-detection tools for hepatocellular carcinoma (HCC), the leading cause of cancer-related death in patients with cirrhosis, and the third most common cause of cancer-related death worldwide.

17 Apr 2026

Synthetic biology approach boosts growth of implanted liver tissue

In patients developing end-stage liver disease, the damage has become too severe for the liver's normally extraordinary regenerative capacity to repair or compensate for it. Once this "point of no return" has been reached, the only option is an organ transplant.

17 Apr 2026

Circulating exosomal microRNAs offer a non-invasive biomarker for MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a global public health challenge with rapidly rising prevalence, especially in China. Despite advances in treatment, the underlying molecular mechanisms remain incompletely understood. A new research article published in the Chinese Medical Journal on March 16, 2026, provides critical insights into the role of exosomal microRNAs (miRNAs) in MASLD pathogenesis.

17 Apr 2026

Donor-derived dendritic cells teach the immune system to accept new livers

UPMC and University of Pittsburgh clinician-scientists have weaned and kept multiple liver transplantation patients off of all immunosuppressant drugs for more than three years through a first-in-human clinical trial of a unique "immune priming" therapy.

17 Apr 2026

Researchers discover a molecular signature to flag dysfunctional aging cells

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation and reversed liver damage in mice - even while the animals remained on an unhealthy diet.

16 Apr 2026

BMI increases in early childhood may reflect muscle growth, not fat

A new study published in The Journal of Nutrition, a peer-reviewed journal of the American Society for Nutrition, offers new insights into a decades-old puzzle in childhood obesity. The study found that while body mass index (BMI) starts to rise in early childhood during a stage known as adiposity rebound, when BMI increases after an initial decline, the waist-to-height ratio, a measure that better reflects body fat, continues to drop. This suggests that the BMI increase at this age mainly reflects growth in lean tissues such as muscle and bone, rather than extra body fat.

16 Apr 2026

Gut-liver changes drive foodborne infection severity in fatty liver disease

A research team led by the University of California, Irvine's Joe C. Wen School of Population & Public Health has uncovered a critical biological link explaining why individuals with metabolic dysfunction–associated steatotic liver disease (MASLD), or fatty liver disease, face significantly worse outcomes from certain foodborne infections.

15 Apr 2026

Semaglutide improves liver function independently of weight loss

Researchers at Toronto's Sinai Health have found that semaglutide – the active ingredient in popular weight loss drugs that mimic the gut hormone GLP-1 – acts directly on a subset of liver cells to improve organ function and does so independently of weight loss.

15 Apr 2026

Liver cancer burden rising globally amid shift to metabolic risks

Primary liver cancer continues to pose a major global health challenge, ranking as the third leading cause of cancer-related deaths worldwide.

15 Apr 2026

Waist-to-height ratio outperforms BMI in predicting hypertension risk

New waist-to-height cut-offs to assess fat mass and obesity predicted the risk of hypertension better than body mass index, according to a new study from the University of Eastern Finland and the Robert Wood Johnson Medical School at Rutgers University in the US.

14 Apr 2026