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Novel sequencing method could be useful for COVID-19 research

Researchers at the University of Chicago and the Cleveland Clinic have presented a novel single-cell RNA sequencing method that could be a useful application for research into the current coronavirus disease 2019 (COVID-19) pandemic.

20 Sep 2020

New partnership aims to advance predictive tests for multiple myeloma in Ireland

By combining genomic testing and next generation sequencing technology, a new partnership led by RCSI researchers aims to advance predictive tests for multiple myeloma, the second most common blood cancer in Ireland.

18 Sep 2020

Study invalidates Ebselen and other broad-spectrum SARS-CoV-2 Mpro inhibitors

Other novel compounds with Mpro inhibitory activity have also been claimed to have antiviral activity. These include ebselen, disulfiram, tideglusib, carmofur, shikonin, and PX-12. A new research paper discusses the role of these molecules as potential Mpro inhibitors in the prevention of SARS-CoV-2 infection.

18 Sep 2020

Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

In a study published in the preprint server bioRxiv, researchers from the Kyoto Prefectural University of Medicine and Osaka University Japan, discuss how they engineered ACE2 to enhance its affinity to RBD in human cells.

17 Sep 2020

Candidate monoclonal antibody shows hope as COVID-19 treatment

Researchers in the United States have described the effectiveness of a candidate monoclonal antibody currently being evaluated in a Phase 1 trial as a therapy for coronavirus disease 2019 (COVID-19) and its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Sep 2020

SMART researchers discover a new way to manufacture human red blood cells

Researchers from Singapore-MIT Alliance for Research and Technology, MIT's research enterprise in Singapore, have discovered a new way to manufacture human red blood cells (RBCs) that cuts the culture time by half compared to existing methods and uses novel sorting and purification methods that are faster, more precise and less costly.

14 Sep 2020

Researchers develop a simple and low-cost platform for diagnosing tropical fevers

Dengue, zika, and chikungunya viruses are transmitted by mosquitoes and cause tropical fevers with similar symptoms, making accurate diagnosis complicated.

10 Sep 2020

Tattoo ink could be the key to improving cancer detection

The humble ink in a tattoo artist's needle could be the key to improving the detection of cancer, thanks to new research from the USC Viterbi Department of Biomedical Engineering.

2 Sep 2020

Negligible ACE2 expression in human beta-cells

Now, a new study published on the preprint server bioRxiv reports that even though the fatality rate is significantly higher in diabetics, there is no evidence that this is due to direct viral infection of pancreatic beta cells, which produce the key hormone in glucose homeostasis, namely insulin.

1 Sep 2020

Cancer cells reshape, destroy or integrate into blood vessels to spread

In laboratory studies, Johns Hopkins Kimmel Cancer Center and Johns Hopkins University researchers observed a key step in how cancer cells may spread from a primary tumor to a distant site within the body, a process known as metastasis.

1 Sep 2020

DeNovix launches 21 CFR Part 11 Compliance Ready software for CellDrop Automated Cell Counters

DeNovix Inc. announces the launch of EasyApps Secure, a 21 CFR Part 11 Compliance Ready software option for CellDrop Automated Cell Counters.

From DeNovix Inc. 31 Aug 2020

Researchers identify roles of matrix stiffness and mechanotransduction in cardiac reprogramming

Cardiovascular disease is the leading cause of death in humans. Worldwide, as the population ages, the burden of treating heart failure is increasing; opportunities for heart transplantation cannot keep pace.

31 Aug 2020

Researchers reveal how bacteria adhere to cellulose fibers in the gut

Researchers have revealed a new molecular mechanism by which bacteria adhere to cellulose fibers in the human gut. Thanks to two different binding modes, they can withstand the shear forces in the body.

28 Aug 2020

Study may help develop new types of non-addictive pain therapies

A team of scientists from ASU's School of Molecular Sciences and the Biodesign Institute have recently published a study in Nature Communications that helps clarify the contributions to an ion channel's temperature - dependent activation. This in turn should aid in the development of new types of non-addictive pain therapies.

27 Aug 2020

Study suggests memory B cells persist following COVID-19 recovery

Researchers at Tel Aviv University in Israel have gained valuable insights into the serological and B cell response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

26 Aug 2020

Study could help understand the evolution of nervous systems in animals and humans

When it comes to brain cells, one size does not fit all. Neurons come in a wide variety of shapes, sizes, and contain different types of brain chemicals. But how did they get that way?

20 Aug 2020

Acidic niche within lymph nodes plays integral role in regulating T cell activation

In the fight against cancer, the immune system is the first line of defense. The lymphatic system specifically is essential to protecting the body against foreign invaders.

19 Aug 2020

Fluorescent molecules in urine can help monitor malignant melanoma

What if you could simply provide a urine sample rather than undergo a painful surgical procedure to find out if your cancer was responding to treatment? It may seem too good to be true, but researchers at Pavol Jozef Šafárik University in Košice, Slovakia, have identified fluorescent molecules in urine that may allow patients with malignant melanoma to do just that.

11 Aug 2020

Study may help optimize materials used in implants, enhance their safety

Using highly complex analytical techniques, a group of researchers from Charité - Universitätsmedizin Berlin were able to observe in detail how different metals are released from joint implants and accumulate in the surrounding bone tissue.

11 Aug 2020

Researchers establish new 3D in vitro model for pulmonary arterial hypertension

Pulmonary arterial hypertension is a rare--albeit deadly--disease that affects the arteries of the lung. In PAH, abnormal growth of cells of the vascular media--or the elastic wall--of the pulmonary arteries, called pulmonary arterial smooth muscle cells, results in thickening of the walls.

7 Aug 2020