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New book serves as reference guide for CNS drugs

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set Medicinal Chemistry for Pharmacy Students serves as a reference guide to pharmacists on aspects of the chemical basis of drug action.

1 Dec 2020

Nucleic acid-hydrolyzing scFv 3D8 exhibits potent antiviral effects on SARS-CoV-2

3D8, a 27-kDa recombinant antibody fragment, was found in autoimmune-prone Murphy Roths Large mice. The single-chain variable fragment (scFv) has the nucleic acid hydrolyzing activity and is shown to degrade DNA or mRNA of viruses in infected cells.

30 Nov 2020

A mutant SARS-CoV-2 subspecies from minks may evade antibody detection

In a recent research letter published on the bioRxiv preprint server, scientists from Japan discovered that the mutation of spike glycoprotein in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) derived from farmed minks can also be found in the group of individuals with coronavirus disease (COVID-19) and subsequently evade detection by our immune system.

30 Nov 2020

Researchers discover molecular mechanism of long-term memory

Researchers at the University of Basel have discovered a molecular mechanism that plays a central role in intact long-term memory. This mechanism is also involved in physiological memory loss in old age.

30 Nov 2020

UC San Diego chosen to lead an international $28-million grant for HIV/AIDS clinical trials

University of California San Diego Collaborative Clinical Trials Unit has been selected by the National Institutes of Health to lead and administer an international seven-year, $28-million grant for science-driven clinical trials that deliver innovative, efficient results needed to turn the corner on the HIV/AIDS pandemic.

30 Nov 2020

Mollusc-derived compounds potential medicines for COVID-19 and other respiratory diseases

A research team has reviewed the existing literature on compounds derived from molluscs used for treating respiratory diseases.

30 Nov 2020

What are the risks associated with human challenge trials for SARS-CoV-2 vaccine candidates?

Researchers from the University of Haifa, Israel, and WAW Statistical Consulting Ltd, UK, designed a model that helps determine the risks faced by participants in a hypothetical COVID-19 dosing study.

30 Nov 2020

Are SARS-CoV-2 protease inhibitors effective antivirals in treating COVID-19?

Many antiviral development studies have focused on the possibility of inhibiting the main viral protease (Mpro), and papain-like protease (PLpro), given their central role in viral replication. A new study draws attention to the high odds that these may not have anti-infective activity because of the redundant pathways present in human host cells.

30 Nov 2020

Excessive use of antibiotics during COVID-19 pandemic could intensify drug resistance

A new study published in the journal Science of The Total Environment in November 2020 discusses this potentially serious issue along with its wider consequences.

30 Nov 2020

Overcoming pediatric drug-resistant TB crisis

World Children's Day marks the day, over three decades ago, on which world leaders adopted the historic Convention of the Rights of the Child, promising to every child to promote and protect their rights, including the right to life and the right to health.

30 Nov 2020

Could the keto diet help prevent or mitigate severe COVID-19?

A new study published in the journal of Translational Medicine reports that the ketogenic diet (KD) may be useful in this area, with its track history of effectual reduction of fat mass, anti-inflammatory and immunomodulatory effects, and consequent improvement of cardiovascular health.

30 Nov 2020

Women face greater risk for heart failure and heart attack death than men, study finds

Women face a 20% increased risk of developing heart failure or dying within five years after their first severe heart attack compared with men.

30 Nov 2020

TRPC1 protein responds to weak magnetic fields to promote muscle health, shows study

As people age, they progressively lose muscle mass and strength, and this can lead to frailty and other age-related diseases. As the causes for the decline remain largely unknown, promoting muscle health is an area of great research interest.

29 Nov 2020

Study pinpoints specific areas of the brain where serotonin promotes patience

We've all been there. Whether we're stuck in traffic at the end of a long day, or eagerly anticipating the release of a new book, film or album, there are times when we need to be patient.

27 Nov 2020

Resveratrol shows potential as SARS-CoV-2 antiviral, study finds

A recent study reveals that resveratrol, a phenolic compound produced by spermatophytes, can inhibit the viral replication SARS-CoV-2.

27 Nov 2020

Could beta-blockers be a potential treatment for COVID-19?

News-Medical spoke to researchers about their latest research into beta-blockers, and how they could potentially be used to treat COVID-19.

27 Nov 2020

Ipom-F inhibits SARS-CoV-2 infection in vitro

An international team of researchers showed the small molecule inhibitor, ipomoeassin F (Ipom-F), blocks the translocation/insertion of the three protein targets for SARS-CoV-2 infection.

27 Nov 2020

Serotonin is vital to the regulation of patience

Delayed gratification is vital to human survival. It allows us to suppress our impulses to behave in ways that gain instant gratification to reap rewards later.

27 Nov 2020

Transgenic mouse model could recapitulate severe COVID-19 in humans

Researchers in the United States and Canada have described the potential for a transgenic mouse model to serve as an effective platform for the study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe disease course in humans.

26 Nov 2020

CARD8 protein regulates inflammatory process in atherosclerosis, study shows

The protein CARD8 regulates several inflammatory proteins in people with atherosclerosis. This is shown in a new study by örebro researchers published in the scientific journal Scientific Reports.

26 Nov 2020