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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Research shows way to directly target genes within specific cell type

The cornerstone of genetics is the loss-of-function experiment. In short, this means that to figure out what exactly gene X is doing in a tissue of interest—be it developing brain cells or a pancreatic tumor—you somehow cut out, switch off or otherwise destroy gene X in that tissue and then watch what happens.

1 Nov 2016

Researchers identify two new potential drug targets for treating atherosclerosis

Researchers at Brigham and Women's Hospital have found two new potential drug targets for treating arterial diseases such as atherosclerosis.

31 Oct 2016

New biological mechanism generates cells to fight against Candida albicans infections, find researchers

Researchers from the Universitat de València and the Cedar Sinai Medical Center in Los Angeles have partnered to describe a biological mechanism that generates cells which are better equipped to fight off serious infections caused by the Candida albicansfungus.

26 Oct 2016

New approach could overcome large immunosuppressive tumors

Harnessing the body's own immune system to destroy tumors is a tantalizing prospect that has yet to realize its full potential. However, a new advance from MIT may bring this strategy, known as cancer immunotherapy, closer to becoming reality.

24 Oct 2016

UCSF researchers find active HIV in tissue samples of patients treated with antiretrovirals

While successful treatment of HIV with antiretroviral medications leads to undetectable levels of virus in the blood, controls the disease and leads to much longer lifespans, scientists know that HIV continues to reside in tissues.

21 Oct 2016

Research shows metabolism of macrophages can be attuned to prevent spread of cancer

Scientists at VIB and KU Leuven have discovered a crucial factor in the spread of cancer. A team led by professor Massimiliano Mazzone has demonstrated that the metabolism of macrophages, a particular type of white blood cell, can be attuned to prevent the spread of cancer.

20 Oct 2016

Optical and PET/CT activity-based probes could help in non-invasive imaging of atherosclerotic plaques

Researchers at Stanford University have demonstrated for the first time the use of a dual optical and PET/CT activity-based probe to detect atherosclerotic plaques. The study is published in the October issue of the Journal of Nuclear Medicine.

20 Oct 2016

Natural compound isolated from onions contains anti-ovarian cancer properties, research finds

Research from Kumamoto University, Japan has found that a natural compound isolated from onions, onionin A (ONA), has several anti-ovarian cancer properties.

20 Oct 2016

Finnish researchers identify molecular mechanism that controls migration of early macrophages

Leukocytes which arise during the embryonic period regulate iron metabolism and the growth of the mammary gland in adults.

17 Oct 2016

UT Southwestern researchers discover protein that leads to brain cell death during stroke

One particular protein is the final executioner of events that result in the death of brain cells during stroke, researchers from UT Southwestern Medical Center and their collaborators report. This finding could ultimately lead to new ways to protect against brain damage.

7 Oct 2016

Added benefit not proven for melanoma drug, IQWiG finds

Talimogene laherparepvec has been approved since December 2015 for adults with advanced melanoma.

7 Oct 2016

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer's.

7 Oct 2016

BGU researchers elucidate molecular mechanism that could lead to new therapies for ALS

Researchers from Ben-Gurion University of the Negev have published a new study that describes a novel molecular mechanism that could lead to the development of new therapies for Amyotrophic Lateral Sclerosis (ALS).

4 Oct 2016

Antibody protection may help control infection caused by TB bacteria

A study led by investigators from the Ragon Institute of MGH, MIT and Harvard finds evidence that antibody protection may help control infection with the bacteria that causes tuberculosis (TB).

4 Oct 2016

Research identifies potential treatment target for chemoresistant cancer cells

A team of researchers has discovered that chemoresistant lung cancer cells suppress immune functions and strengthen resistance to chemotherapy by producing interleukin-34 (IL-34)—a type of cytokine.

3 Oct 2016

DHA intake can prevent known trigger of lupus, study finds

A team of Michigan State University researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders.

30 Sep 2016

Researchers discover how signals from infectious bacteria get to inflammasome sensors

Researchers at St. Jude Children's Research Hospital have discovered the way signals from infectious bacteria gain entry into the cytoplasm of host cells to activate disease-fighting inflammasomes.

29 Sep 2016

New project clarifies molecular processes involved in hidden HIV reservoir

In spite of ever more effective therapies, HIV keeps managing to survive in the body. A comprehensive project conducted by the Austrian Science Fund FWF has clarified the molecular processes which contribute to this effect.

27 Sep 2016

Researchers identify new immune cell that protects mice from lung infections during chemotherapy

St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy.

27 Sep 2016

Novartis gets three FDA approvals for expanded use of biologic drug to treat rare autoinflammatory diseases

Novartis announced today that the US Food and Drug Administration has granted three simultaneous approvals for the expanded use of Ilaris (canakinumab) to treat three rare and distinct types of Periodic Fever Syndromes.

24 Sep 2016

Macrophage News and Research

Further Reading

Research shows way to directly target genes within specific cell type

Researchers identify two new potential drug targets for treating atherosclerosis

New biological mechanism generates cells to fight against Candida albicans infections, find researchers

New approach could overcome large immunosuppressive tumors

UCSF researchers find active HIV in tissue samples of patients treated with antiretrovirals

Research shows metabolism of macrophages can be attuned to prevent spread of cancer

Optical and PET/CT activity-based probes could help in non-invasive imaging of atherosclerotic plaques

Natural compound isolated from onions contains anti-ovarian cancer properties, research finds

Finnish researchers identify molecular mechanism that controls migration of early macrophages

UT Southwestern researchers discover protein that leads to brain cell death during stroke

Added benefit not proven for melanoma drug, IQWiG finds

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

BGU researchers elucidate molecular mechanism that could lead to new therapies for ALS

Antibody protection may help control infection caused by TB bacteria

Research identifies potential treatment target for chemoresistant cancer cells

DHA intake can prevent known trigger of lupus, study finds

Researchers discover how signals from infectious bacteria get to inflammasome sensors

New project clarifies molecular processes involved in hidden HIV reservoir

Researchers identify new immune cell that protects mice from lung infections during chemotherapy

Novartis gets three FDA approvals for expanded use of biologic drug to treat rare autoinflammatory diseases

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