Respiratory News and Research

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SARS-CoV-2 cell entry affinity varies across different host species

A new study from India, currently available on the preprint server bioRxiv*, estimated the probability and readiness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect cells of different animal species – and revealed many of them that could act as disease carriers.

12 May 2020

Clinical trial to test the efficacy of defibrotide medicine for reducing COVID-19 death rate

The Neurosciences Institute, mixed centre of the Spanish National Research Council and the Miguel Hernández University of Elche, have collaborated on the first clinical trial conducted in the world to test whether the defibrotide medicine, which has already been authorized to treat a severe obstruction of the hepatic sinusoidal veins of people who have undergone a bone marrow transplant, can be used as therapy against COVID-19.

12 May 2020

Study illuminates the impact of COVID-19 on hospitals and health systems

In the third week of March 2020, as the COVID-19 pandemic escalated, large hospitals in the Northeast experienced a 26 percent decline in average per-facility revenues based on estimated in-network amounts as compared to the same period in 2019.

12 May 2020

Sanford director receives major grant to advance broad-spectrum antivirals for respiratory diseases

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce that Sumit Chanda, Ph.D., has received a $10.2 million, four-year grant from the Department of Defense to develop and advance broad-spectrum antivirals for respiratory diseases.

12 May 2020

Novel telemedicine platform protects health professionals caring for patients with infectious diseases

Physician-scientists have developed a communication management system built on a telemedicine platform that can help minimize the exposure of health care professionals to highly infectious diseases while still providing personalized patient care, according to a new report published online in the Annals of the American Thoracic Society.

12 May 2020

COVID-19 patients improve after experimental heart cell therapy

Four of six critically ill COVID-19 (coronavirus) patients significantly improved after receiving an experimental therapeutic designed to reduce inflammation, a major cause of death from this disease, according to a case series published by Cedars-Sinai and Capricor Therapeutics.

12 May 2020

‘No intubation’: Seniors fearful of COVID-19 are changing their living wills

Last month, Minna Buck revised a document specifying her wishes should she become critically ill.

12 May 2020

Millions stuck at home with no plumbing, kitchen or space to stay safe

In nearly half a million American homes, washing hands to prevent COVID-19 isn't as simple as soaping up and singing "Happy Birthday" twice while scrubbing.

12 May 2020

Leica Microsystems Donate an Advanced Microscopy System to Charité’s Institute of Virology to Progress Covid-19 Research

Since the start of the current coronavirus outbreak, the Institute of Virology on Campus Charité Mitte, led by Director Prof. Dr. Christian Drosten, has been at the forefront of viral research into SARS-CoV-2, the virus that causes Covid-19.

From Leica Microsystems GmbH 12 May 2020

Potential for COVID-19 transmission from human eye

A new study published on the preprint server bioRxiv* in May 2020 reports the presence of ACE2 receptors in the eye at high concentrations. These molecules are the entry points for the SARS-CoV-2 virus that is causing the ongoing COVID-19 pandemic.

12 May 2020

Does cholesterol play a role in COVID-19?

A new study published on the preprint server bioRxiv in May 2020 suggests that the strikingly increased mortality in COVID-19 patients who are either old or also have high blood pressure, diabetes, cardiovascular disease is due to high tissue cholesterol levels. It also indicates the role of a healthy diet, by showing that polyunsaturated fatty acids (PUFA) in blood oppose the effects of cholesterol and thus the risk for severe COVID-19 symptoms.

12 May 2020

Symptomatic COVID-19 patients less likely to be smokers

As the COVID-19 pandemic rages in many parts of the world, a new study shows that smoking may not play a significant role in increasing the severity of illness in these patients. The study is published on the preprint server medRxiv* in May 2020.

12 May 2020

SARS-CoV-2 binds heparan sulfate, preventing host cell infection

A new study published in May 2020 on the preprint server bioRxiv shows that the SARS-CoV-2 virus can bind to a sugar molecule called heparan sulfate (HS), thereby hindering its entry into the host cell.

12 May 2020

Antiviral cocktail may help treat mild COVID-19 patients

The skyrocketing number of cases due to the coronavirus pandemic has taken a massive toll on the health systems in many countries. Since the advent of the coronavirus disease (COVID-19), hundred of research teams are racing to find an effective vaccine and treatment to combat the deadly infection. Now, a team of researchers in Hong Kong suggests that combining three existing antivirals may help treat COVID-19 patients.

12 May 2020

Smart health system to monitor people in COVID-19 quarantine

The global coronavirus pandemic has spread to 187 countries and territories, infecting more than 4.17 million people. Most countries, especially those with a skyrocketing caseload, grapple with a lack of hospital beds and facilities to cater to every patient infected with the virus. Now, a team of researchers may have the solution to this problem – a smart health system to monitor patients who are in home isolation.

12 May 2020

Hydroxychloroquine is not effective against COVID-19, extensive U.S. study shows

Over the past few months, doctors resorted to repurposing medicines that have already been approved for other diseases to treat coronavirus patients. One drug that was widely used in the pandemic, hydroxychloroquine, has been found to be ineffective in treating the viral infection.

11 May 2020

SARS-CoV-2 could spread through surface of the eyes

Researchers from Johns Hopkins University School of Medicine have found that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus could spread via ocular or eye surfaces. This is because the receptor where the virus binds – the ACE2, is also expressed on human eyes, they note.

11 May 2020

Genomic sequences from all over the world help fight SARS-CoV-2

As the COVID-19 pandemic rages across the world, killing hundreds of thousands and infecting over 4.1 million, researchers are racing against time to understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 genome has now been sequenced in many different regions of the world, and researchers are collaborating by sharing information to better understand the make-up and mutations that the virus has undergone.

11 May 2020

Varied performance of SARS-CoV-2 antibody tests in detecting protective immunity

The performance of commercially available serological tests in real patient samples and the correlates of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provided by IgG antibodies are still a matter of debate. A new bioRxiv preprint paper cross-examines the performance of several assays and proclaims the plaque reduction neutralization test (PRNT) as a method of choice.

11 May 2020

Microbiome controls the fitness of our immune system

Working alongside colleagues in Mainz, Bern, Hannover and Bonn, researchers from Charité - Universitätsmedizin Berlin, the Berlin Institute of Health and the German Rheumatism Research Center Berlin were able to show how the microbiome helps to render the immune system capable of responding to pathogens.

11 May 2020