Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Pharmacological stimulation of nicotinic receptor could be strategy to treat lung inflammation

It has been amply proven that smoking can cause serious diseases such as emphysema and cancer. A new study, however, shows that pharmacological stimulation of a specific type of nicotinic receptor in cells of the immune system could be a strategy to treat inflammatory lung disease.

20 Oct 2017

Cells lining blood vessels in the lungs exposed to bacterial toxins don’t die easy, UIC study says

Cells lining blood vessels in the lungs that are exposed to bacterial toxins don't die easy, according to a new study led by researchers at the University of Illinois at Chicago College of Medicine.

10 Oct 2017

Researchers uncover promising targets for development of drugs against leishmaniasis

Brazilian researchers at the University of São Paulo's Bioscience Institute (IB-USP) are starting to unravel the molecular mechanisms by which the parasite that causes cutaneous leishmaniasis manages to circumvent the host organism's defenses and infect new cells.

5 Oct 2017

Drug targeting approach could lead to improved therapies for immune-related diseases

A new technique that targets drugs to specific cells could lead to improved therapies for diseases caused by an overactive immune response.

25 Sep 2017

Researchers identify molecular pathway that causes immune cells to promote cancer

Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles have identified new findings about an immune cell - called a tumor-associated macrophage - that promotes cancer instead of fighting it.

21 Sep 2017

Researchers identify exosomes as missing link to insulin resistance in type 2 diabetes

Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes. But the mechanism by which this occurs has remained cloaked, until now.

21 Sep 2017

Regeneration ability may lie with the body's innate immune system, study shows

The answer to regenerative medicine's most compelling question -- why some organisms can regenerate major body parts such as hearts and limbs while others, such as humans, cannot -- may lie with the body's innate immune system, according to a new study of heart regeneration in the axolotl, or Mexican salamander, an organism that takes the prize as nature's champion of regeneration.

21 Sep 2017

Poliovirus therapy triggers longer-lasting immune response against malignant tumors

An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells to evade the immune system.

20 Sep 2017

Researchers identify natural protective factor against chronic inflammation in diabetes patients

In type 2 diabetes, chronic inflammation drives cardiovascular disease, the leading cause of death among people with the condition. Researchers at Joslin Diabetes Center now have identified an unexpected natural protective factor that works against this inflammation.

20 Sep 2017

Scientists discover markers for progressive multiple sclerosis

Scientists have uncovered two closely related cytokines -- molecules involved in cell communication and movement -- that may explain why some people develop progressive multiple sclerosis (MS), the most severe form of the disease.

18 Sep 2017

Insmed reports top-line data from Phase 3 study of new treatment in patients with NTM lung disease

Insmed Incorporated, a global biopharmaceutical company focused on the unmet needs of patients with rare diseases, today announced top-line data from its Phase 3 CONVERT study.

13 Sep 2017

Component of fire ant venom shows promise as a psoriasis treatment

In a new study involving laboratory mice, researchers have found that solenopsin and similar compounds could be beneficial for psoriasis.

11 Sep 2017

Immune response to parasite varies depending on what time infection occurs, study shows

Does the time of day matter when our body is infected by a parasite? According to new research from McGill University, it matters a great deal.

11 Sep 2017

Fatty acid-derived bioactive molecule helps improve heart function after heart attack in mice

Heart attacks provoke an acute immune response. Leukocytes rush to the heart muscle to remove dead cells and begin building scar tissue. This is followed by a second immune response, the resolving phase that allows healing.

7 Sep 2017

Molecular map shows novel way to stop dangerous bioweapon

During World War II, the Soviet Red Army was forced to move their biological warfare operations out of the path of advancing Nazi troops. Among the dangerous cargo were vials of Francisella tularensis, the organism that causes tularemia and one of the world's most infectious pathogens.

6 Sep 2017

Protein distribution channel may be new target for combating pathogenic bacterium

A bacterium that attacks people suffering from chronic lung disease and compromised immune systems could be halted by disrupting the distribution channels the organism uses to access the nutrient-rich cytoplasm of its host cell.

31 Aug 2017

Targeting bone marrow protein could be effective way to improve stem cell transplants

Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during systemic infection, creating new blood cells, including immune cells, in a process known as hematopoiesis.

28 Aug 2017

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Whenever an organism is damaged, the cells surrounding the wound receive signals to proliferate more intensely so as to regenerate the injured tissue.

26 Aug 2017

Research reveals underlying reason for intense pain in patients with shingles

Chickenpox is a typical childhood illness. In most cases, it is benign, and the symptoms disappear within ten days. However, its causative agent, Varicella zoster virus (VZV), remains in the organism forever. In some cases, the virus can be reactivated years later, causing a different disease known as herpes zoster, or shingles.

24 Aug 2017

Researchers identify important adenovirus receptor in macrophages of mice

Adenoviral infections have a mild disease progression in healthy people, but it can be dangerous for immunocompromised people.

24 Aug 2017

Macrophage News and Research

Further Reading

Pharmacological stimulation of nicotinic receptor could be strategy to treat lung inflammation

Cells lining blood vessels in the lungs exposed to bacterial toxins don’t die easy, UIC study says

Researchers uncover promising targets for development of drugs against leishmaniasis

Drug targeting approach could lead to improved therapies for immune-related diseases

Researchers identify molecular pathway that causes immune cells to promote cancer

Researchers identify exosomes as missing link to insulin resistance in type 2 diabetes

Regeneration ability may lie with the body's innate immune system, study shows

Poliovirus therapy triggers longer-lasting immune response against malignant tumors

Researchers identify natural protective factor against chronic inflammation in diabetes patients

Scientists discover markers for progressive multiple sclerosis

Insmed reports top-line data from Phase 3 study of new treatment in patients with NTM lung disease

Component of fire ant venom shows promise as a psoriasis treatment

Immune response to parasite varies depending on what time infection occurs, study shows

Fatty acid-derived bioactive molecule helps improve heart function after heart attack in mice

Molecular map shows novel way to stop dangerous bioweapon

Protein distribution channel may be new target for combating pathogenic bacterium

Targeting bone marrow protein could be effective way to improve stem cell transplants

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Research reveals underlying reason for intense pain in patients with shingles

Researchers identify important adenovirus receptor in macrophages of mice

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