Clinical Trial News and Research

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Transcendental Meditation may offer lasting benefits for heart health in high-risk Black adults

A newly published randomized controlled trial in Frontiers in Medicine has found that the practice of Transcendental Meditation® (TM) may significantly reduce the risk of major adverse cardiovascular events (MACE) in Black men and women at high risk for heart disease.

5 Jun 2025

Early heart ultrasound may predict birth complications in babies

An echocardiography of the baby's little heart soon after the onset of labour can predict the outcome of the birth and in particular whether the baby will adequately tolerate the contractions or will be more likely to go into distress, necessitating a caesarean section or an operative delivery.

5 Jun 2025

Study: Deceased-donor kidney transplants do not benefit all patients equally

A major international study, being presented today at the 62nd ERA Congress, reveals that the long-accepted survival advantage of deceased-donor kidney transplantation does not extend equally to every patient and every donor organ.

5 Jun 2025

Genetic mutation identified as key factor in immunotherapy resistance for melanoma

Tests in 1,225 patients with the most deadly form of skin cancer reveal for the first time a genetic trait among most of those who did not respond to the latest cancer treatments, known as immune checkpoint inhibitors.

5 Jun 2025

DANTE trial reveals promising outcomes for shortened immunotherapy in advanced melanoma

Reducing the length of immunotherapy treatment for an advanced skin cancer did not significantly diminish disease control when compared to giving treatments over a longer period, according to breakthrough research led by the Universities of Sheffield and Leeds and Sheffield Teaching Hospitals NHS Foundation Trust.

5 Jun 2025

Nicotinamide riboside shows promise in treating Werner syndrome symptoms

Werner syndrome (WS) is a rare genetic disorder that causes premature aging and serious complications. In the first clinical trial of its kind, researchers from Japan with the company Niagen Bioscience, investigated the effects of nicotinamide riboside (NR), a vitamin B3 derivative, in patients with WS.

5 Jun 2025

P2Y12 inhibitors linked to lower rates of cardiovascular events compared to aspirin

Giving a P2Y12 inhibitor anti-clotting drug to patients with coronary artery disease is associated with lower rates of cardiovascular death, heart attack and stroke compared with traditional aspirin, with no increased risk of major bleeding, finds a study published by The BMJ today.

5 Jun 2025

Type 2 diabetes drug shows improvements for patients with progressive liver disease

The sodium glucose cotransporter 2 (SGLT-2) inhibitor drug dapagliflozin, widely used to treat type 2 diabetes, also shows improvements for patients with progressive liver disease, finds a clinical trial from China published by The BMJ today.

5 Jun 2025

Statins show no additional benefit for depression treatment

Lipid-lowering medicines, known as statins, are prescribed in cases of high cholesterol levels, to reduce the risk of atherosclerosis, heart attack and stroke.

4 Jun 2025

AI-designed drug shows early promise for lung fibrosis patients in clinical trial

Researchers report that rentosertib, an AI-discovered TNIK inhibitor, showed promising safety and potential to improve lung function in patients with idiopathic pulmonary fibrosis in a 12-week phase 2a clinical trial. The highest dose group demonstrated a trend toward increased forced vital capacity, especially among patients not receiving standard antifibrotic therapy, supporting further clinical investigation.

4 Jun 2025

SWOG S2302 Pragmatica-Lung study demonstrates value of streamlined clinical trials in real world settings

The SWOG S2302 Pragmatica-Lung trial, which broke new ground with its streamlined pragmatic design, unusually broad eligibility criteria, and reduced data collection, has quickly answered its primary question, finding that the investigational combination it tested did not significantly extend overall survival compared to standard of care treatments.

4 Jun 2025

Does lithium offer hope for long COVID brain fog and fatigue? New trial gives mixed results

A randomized clinical trial found that low-dose lithium aspartate did not improve cognitive dysfunction or fatigue in long COVID patients. Higher doses showed possible benefits in a small exploratory substudy, but larger trials are needed.

4 Jun 2025

New mouse model sheds light on smell loss and neural regeneration

A new study suggests that stem cells thought to be dormant may offer clues to why our sense of smell declines or is lost.

3 Jun 2025

Can tech reduce drinking and boost sleep for young adults?

The Yale-led study explores the effectiveness of digital interventions in improving sleep and reducing alcohol use among young adults, with encouraging results.

3 Jun 2025

PfSPZ-LARC2 malaria vaccine advances to new age groups after successful safety review

Physician-scientists at Groupe de Recherche Action en Santé (GRAS) in Burkina Faso have successfully completed initial safety evaluations in 30 adult Burkinabés as the first phase of a clinical trial of Sanaria PfSPZ-LARC2 Vaccine, which is designed to prevent infection with Plasmodium falciparum malaria.

3 Jun 2025

Transforming IBS treatment through psychedelic medicine

In a comprehensive Genomic Press Interview published today, Dr. Erin E. Mauney reveals how her pioneering research brings psychedelic medicine into gastroenterology for the first time, potentially transforming treatment for millions suffering from intractable irritable bowel syndrome (IBS).

3 Jun 2025

Female athletes show unique heart adaptations compared to males

Intensive exercise- and sport changes the heart of an athlete. Research led by Amsterdam UMC shows that the hearts of female athletes have different characteristics than those of male athletes.

3 Jun 2025

Asthma drug once hoped to treat alcohol use disorder fails to meet expectations in UCLA trial

A drug that once showed promise as a treatment for alcohol use disorder did not work as expected, a new UCLA clinical trial found.

3 Jun 2025

High-fiber plant-based diet could benefit patients at risk for developing multiple myeloma

Results from a new clinical trial suggest that a high-fiber plant-based diet could benefit patients at risk for developing multiple myeloma, the second most common type of blood cancer.

2 Jun 2025

First-in-class antibody-drug conjugate shows high response rates in rare blood cancer trial

The first-in-class antibody-drug conjugate (ADC) pivekimab sunirine (PVEK) demonstrated promising efficacy and high response rates for patients with blastic plasmacytoid dendric cell neoplasm (BPDCN), according to data from a Phase I/II study led by researchers from The University of Texas MD Anderson Cancer Center.

2 Jun 2025

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Clinical Trial News and Research

Transcendental Meditation may offer lasting benefits for heart health in high-risk Black adults

Early heart ultrasound may predict birth complications in babies

Study: Deceased-donor kidney transplants do not benefit all patients equally

Genetic mutation identified as key factor in immunotherapy resistance for melanoma

DANTE trial reveals promising outcomes for shortened immunotherapy in advanced melanoma

Nicotinamide riboside shows promise in treating Werner syndrome symptoms

P2Y12 inhibitors linked to lower rates of cardiovascular events compared to aspirin

Type 2 diabetes drug shows improvements for patients with progressive liver disease

Statins show no additional benefit for depression treatment

AI-designed drug shows early promise for lung fibrosis patients in clinical trial

SWOG S2302 Pragmatica-Lung study demonstrates value of streamlined clinical trials in real world settings

Does lithium offer hope for long COVID brain fog and fatigue? New trial gives mixed results

New mouse model sheds light on smell loss and neural regeneration

Can tech reduce drinking and boost sleep for young adults?

PfSPZ-LARC2 malaria vaccine advances to new age groups after successful safety review

Transforming IBS treatment through psychedelic medicine

Female athletes show unique heart adaptations compared to males

Asthma drug once hoped to treat alcohol use disorder fails to meet expectations in UCLA trial

High-fiber plant-based diet could benefit patients at risk for developing multiple myeloma

First-in-class antibody-drug conjugate shows high response rates in rare blood cancer trial

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