Lipids News and Research

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Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules.

American Heart Association's 9 diet rules to lower heart disease risk

The AHA's dietary guidance emphasizes food choices over fad diets to reduce heart disease risk and improve cardiovascular health across all life stages.

2 Apr 2026

Impaired lipid transport protein locks stressed cells into cellular limbo

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative senescence, cells remain alive but no longer proliferate.

31 Mar 2026

APOE4 alters brain immunity and cognition differently in females and males

APOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive vulnerability. Suppressing innate immunity improved some cognitive outcomes in female E4/E4 mice but worsened them in male E4/E4 mice, underscoring the need for sex-tailored approaches.

29 Mar 2026

Updated heart guidelines urge earlier screening for high blood cholesterol

For the first time since 2018, a clinical guideline from the American College of Cardiology and the American Heart Association for screening and managing blood cholesterol levels has been updated and jointly published in the Journal of the American College of Cardiology and Circulation.

27 Mar 2026

UPFs before conception may shape fertility and embryo growth

Findings show ultraprocessed food consumption before conception influences fertility and embryonic development, urging further research in this area.

26 Mar 2026

New pathway enhances brown fat thermogenesis and metabolic health

Researchers have determined how a key protein activates brown fat by expanding blood vessels and nerves in the heat-generating tissue.

25 Mar 2026

Can collagen supplements really improve your skin?

Investigating collagen peptides, this review explores their role in skin aging, assessing clinical evidence and the mechanisms behind their potential benefits.

25 Mar 2026

Redesigned lipid nanoparticles improve mRNA delivery to lymph nodes

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery to the liver.

24 Mar 2026

Gut microbes drive fat browning in response to diet

White adipose tissue stores energy, while brown and beige fat burn energy through thermogenesis. Under certain environmental conditions, white fat can transition into beige fat in a process known as browning.

24 Mar 2026

Palmatine improved fatty liver markers in a preclinical type 2 diabetes study

Researchers used a bioinformatics-plus-rat-model approach to investigate how palmatine may help treat T2DM-associated MASLD, identifying five core targets: ADRB2, BCL3, EGR1, FOS, and MAP3K8. In rats, palmatine improved liver injury, inflammation, oxidative stress, glycolipid metabolism, steatosis, and fibrosis, while reducing apoptosis-related signaling, providing a preclinical foundation for further therapeutic study.

23 Mar 2026

New cholesterol guidelines emphasize earlier risk assessment and prevention

New national guidance for managing cholesterol and other blood lipids emphasizes earlier risk assessment, more personalized treatment, and long-term prevention—including, in some cases, treatment beginning as early as age 30.

23 Mar 2026

Early obesity treatment reduces long-term health risks for all children

Children living with obesity but showing no signs of metabolic complications still have a significantly increased risk of developing type 2 diabetes, high blood pressure, and abnormal blood lipid levels later in life.

23 Mar 2026

Gut-derived blood markers may help predict who develops coronary heart disease

Researchers used five prospective cohorts from the US and China to identify circulating gut microbiota-related metabolites linked to future coronary heart disease, then tested the findings through discovery, in silico validation, and targeted quantitative validation. The study ultimately highlighted nine metabolites associated with incident CHD, supporting a potential role for microbial metabolism in heart disease risk while not proving causation

18 Mar 2026

Modified lipid nanoparticles boost mRNA vaccines while reducing side effects

The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever and general malaise.

17 Mar 2026

Reducing lung cell lipid production decreases metastatic tumor spread

Scientists from the VIB–KU Leuven Center for Cancer Biology, in collaboration with the Francis Crick Institute, have discovered how cancer cells can exploit healthy lung cells to support metastatic tumor growth in the lungs.

17 Mar 2026

Researchers show how smartwatches can help identify insulin resistance

Researchers developed a scalable framework that predicts insulin resistance using wearable-device signals, routine blood biomarkers, and demographic data, with stronger performance when these data streams were combined. The study also introduced an AI agent to explain insulin resistance risk, interpret results, and support earlier metabolic risk screening.

17 Mar 2026

Study uncovers how tuberculosis bacteria fuel themselves during infection

Researchers at The Hospital for Sick Children (SickKids) have uncovered how the bacteria that causes tuberculosis fuels itself during infection, providing new insights into one of the world's deadliest infectious diseases.

17 Mar 2026

Updated guideline emphasizes earlier treatment for high cholesterol

The American College of Cardiology (ACC), the American Heart Association and nine other leading medical associations, today issued an updated guideline for the management of dyslipidemia-abnormal levels of one or more types of lipids or lipoproteins in the blood, including cholesterol and triglycerides.

13 Mar 2026

Using blood proteins to make living brains transparent

Making a living brain transparent and watching its neurons fire without disturbing their function-sounds like science fiction, doesn't it? Yet the solution may already exist within our own bodies.

13 Mar 2026