Mass Spectrometry News and Research

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Mass spectrometry is an analytical method used to identify different compounds based on the atomic sample constitution of the molecules and their charge state, which enables “blind” analysis of an unknown sample without any prior knowledge of its composition.

Virus shells use asymmetry to control RNA release and infection

Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, but new research led by scientists at Penn State reveals a deliberate imbalance in their shape that helps them infect their hosts.

12 Dec 2025

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers profiled a terminally sterilized probiotic-fermented MFH beverage and identified aporphine alkaloids and flavonoids with favorable predicted ADMET properties. Integrated network pharmacology, molecular docking, and 100-ns MD simulations suggest multi-target engagement of metabolic-inflammatory pathways relevant to obesity and type 2 diabetes.

9 Dec 2025

Online reference library provides a more accurate picture of drug exposure

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete.

9 Dec 2025

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Supportive marital relationships are associated with lower BMI, fewer food addiction symptoms, higher oxytocin, stronger frontal brain responses to food cues, and favorable gut tryptophan metabolites. These coordinated social, neural, hormonal, and gut pathways suggest a plausible biological link between emotional support and healthier eating regulation.

8 Dec 2025

Lubiprostone shows signs of slowing kidney function decline in chronic kidney disease

In adults with stage IIIb–IV chronic kidney disease, the constipation drug lubiprostone did not reduce gut-derived uremic toxins but preserved creatinine-based kidney function over 24 weeks. The benefit was linked to microbiome remodeling, increased polyamine production, and improved mitochondrial function rather than toxin lowering.

8 Dec 2025

Sweat testing could transform drug monitoring and diabetes care

Innovative sweat sampling techniques could revolutionize diagnostics, offering insights into glucose levels and environmental toxins with minimal discomfort.

4 Dec 2025

Fanconi anemia patients show striking metabolic differences

Experts at Cincinnati Children's have uncovered striking metabolic differences in people with Fanconi anemia (FA), a rare genetic disorder that causes bone marrow failure and dramatically increases cancer risk.

29 Nov 2025

Chronic drinking weakens the blood-brain barrier through the gut

Chronic alcohol consumption disrupts the blood-brain barrier, but Faecalibacterium prausnitzii shows promise in repairing this damage and improving cognition.

27 Nov 2025

Scientists identify cellular control points to tackle multiple viruses

Scientists were pleased when they learned more about how the common cold gains a foothold in the body, identifying key cellular checkpoints that are important targets of the virus.

21 Nov 2025

Can black cumin help fight obesity?

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20 Nov 2025

Trial investigates how quickly human milk responds to common plant based meat swaps

Replacing beef with a plant based beef substitute for six days changed the fatty acid composition of human milk, increasing medium chain saturated fats and lowering key long chain polyunsaturated fats such as arachidonic acid. These biochemical shifts occurred without changes in maternal weight, appetite, glucose patterns or infant milk intake.

18 Nov 2025

Preclinical study shows aged garlic extract improves memory and reduces anxiety

Long-term aged garlic extract supplementation improved specific anxiety-related behaviors and enhanced memory and learning in aging mice. Proteomic profiling revealed extensive hippocampal and cortical molecular changes linked to synaptic signaling, neuroplasticity, and stress-response pathways.

16 Nov 2025

Bruker announces advancements in immunopeptidomics, de novo PTM analysis, and proteoform profiling

international HUPO, Bruker Corporation today announced new machine learning additions to Bruker ProteoScape™ software for immunopeptidomics and PTM analysis.

From Bruker Daltonics 14 Nov 2025

Cornell team unveils high-resolution tool for tracking kinase activity

Cornell researchers have developed a powerful new biosensor that reveals, in unprecedented detail, how and where kinases – enzymes that control nearly all cellular processes – turn on and off inside living cells.

13 Nov 2025

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025

Scientists map kinesin-2 tail structure to understand cargo binding

For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo remained a mystery. The new study provides a key piece of this puzzle by revealing the atomic-level structure of the kinesin-2 tail and its interaction with cargo and adaptor proteins.

6 Nov 2025

MIT researchers identify new vaccine targets to fight tuberculosis

A large-scale screen of tuberculosis proteins has revealed several possible antigens that could be developed as a new vaccine for TB, the world's deadliest infectious disease.

5 Nov 2025

Even low PFAS in drinking water raise blood levels, California study shows

Researchers in Southern California found that even low levels of PFAS (“forever chemicals”) in public drinking water lead to measurable increases in blood PFAS concentrations. The study underscores the urgent need for stronger water-quality monitoring and stricter PFAS regulations across non-industrial regions.

2 Nov 2025

Baby formula can harbor heat-resistant bacteria even after safe preparation

Research shows that powdered infant formula may contain microbial contaminants despite following 70°C preparation guidelines, highlighting potential risks.

31 Oct 2025