Mouse Model News and Research

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Researchers challenge the traditional understanding of how histone deacetylase inhibitors function

Researchers at Baylor College of Medicine and collaborating institutions are challenging the traditional understanding of how cancer drugs called histone deacetylase (HDAC) inhibitors function.

5 Jun 2026

Study validates research models for tracking circular extra-chromosomal DNA

Damage to DNA in cancer cells can lead to pieces breaking off chromosomes and floating away, like icebergs cracking off from a glacier.

5 Jun 2026

Noninvasive technology detects early intestinal disease in premature infants

A new noninvasive technology, called broadband optical spectroscopy (BOS), has promise to reliably detect necrotizing enterocolitis (NEC) in premature infants at earlier stages, before this devastating intestinal disease progresses enough to be visible on x-ray, according to a first-in-human study from Ann & Robert H. Lurie Children's Hospital of Chicago published in the Journal of Pediatric Surgery.

5 Jun 2026

Antibody fragment offers safer alternative for Alzheimer disease treatment

In 2025, the European Medicines Agency approved two antibodies for Alzheimer's disease: lecanemab (Leqembi, from Biogen) and donanemab (KisunlaTM, from Eli Lilly and Company), both based on immunotherapy (the use of molecules from the immune system to treat diseases).

5 Jun 2026

AI detects early warning signs of epilepsy without visible seizures

Epilepsy isn't always easy to diagnose. Seizures often don't occur during routine brain-wave recordings (EEGs), leaving doctors without the direct observation they need to make a clear diagnosis.

4 Jun 2026

Brain stroke injuries trigger lipid increases that cause bilateral limb pain

A stroke is a devastating condition that disrupts proper brain function.

3 Jun 2026

New PET imaging approach quantifies synaptic pathology in multiple sclerosis

A new PET imaging approach that measures synaptic density in the spinal cord provides a quantitative way to assess the brain's functional wiring in patients with multiple sclerosis.

2 Jun 2026

Modified stem cell therapy reverses new-onset Type 1 diabetes in mice

A group of researchers at the Medical University of South Carolina (MUSC) has recently developed a new stem cell therapy with a remarkable ability to reverse new-onset Type 1 diabetes (T1D) in a mouse model of the disease.

2 Jun 2026

Microenvironmental CTHRC1 protein promotes colorectal cancer tumor growth

A new research paper was published in Volume 17 of Oncotarget on May 20, 2026, titled "Microenvironmental CTHRC1 has a pro-tumorigenic role in colorectal cancer."

2 Jun 2026

How dysregulated collagen IV homeostasis causes cerebral microbleeds

Millions of older adults have tiny brain hemorrhages called cerebral microbleeds, which are strongly associated with dementia, cognitive decline, and stroke.

2 Jun 2026

New magnetic particle imaging ensures precision cell therapy injection tracking

Scientists at Johns Hopkins Medicine say they used a form of magnetic imaging to track cell therapy injections commonly used to treat certain autoimmune diseases and cancers.

2 Jun 2026

New mRNA treatment improves recovery following heart attacks

A heart attack is far from being an isolated, acute event. The consequences of an attack can cause serious and lasting damage, including heart failure.

1 Jun 2026

Mature intestinal cells regain stem cell behavior to trigger tumor growth

In a groundbreaking study, Stevens researchers show how colorectal cancers can evolve from mature intestinal cells that revert to stem cells.

1 Jun 2026

Justicia carnea extract alleviates oxidative stress in pancreatitis

Chronic pancreatitis is an inflammatory disease and is difficult to manage despite advancements in medical science.

1 Jun 2026

Gladstone scientists track exact routes used to clear brain waste

Think of the brain as if it were a house. Insulated from its environment, a house relies on complex networks-pipes, drains, and disposal systems-that interface with the outside world to keep the home functional on the inside.

29 May 2026

PET microplastics remain in lungs and worsen respiratory tract inflammation

Microplastics (MP) are the subject of intensive medical research, but little is yet known about their effects on the immune system.

29 May 2026

Scientists uncover shared gene signatures that reveal how mammals age

Researchers mapped more than 11,000 transcriptomes across mice, rats, macaques, and humans, revealing conserved molecular signatures of aging and mortality across tissues, species, and cell types. The study developed interpretable transcriptomic clocks that track age, mortality-related molecular change, chronic disease signals and responses to lifespan-altering interventions.

29 May 2026