Mouse Model News and Research

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Biliary epithelial cells found to actively prevent liver fibrosis development

Many liver diseases share a common characteristic: fibrosis, that is, the progressive accumulation of scarring in the liver tissue.

28 Apr 2026

A new biological switch to slow atherosclerosis progression

A study by researchers at Baylor College of Medicine and collaborating institutions reveals a previously unrecognized way blood vessels can protect themselves from damage and slow the development of atherosclerosis. The findings, published in the Proceedings of the National Academy of Sciences, have implications for both vascular precision medicine and the safety of certain emerging cancer treatments.

28 Apr 2026

New immune mapping tool reveals how lung cancer reshapes immune cells

Researchers at VIB and VUB have developed a powerful new way to study how the immune system behaves inside lung tumors.

27 Apr 2026

The heart's constant beating suppresses tumor growth in cardiac tissues

The heart's constant beating may actively suppress tumor growth in cardiac tissues, a new study reports. This is because cellular pathways in these tissues alter gene regulation in cancer cells to keep them from proliferating.

25 Apr 2026

Intercellular heme transfer pathway sustains red blood cell production under stress

Scientists have long been puzzled by how maturing red blood cells manage to produce all the hemoglobin they need to carry oxygen to tissues, even after shedding the vital structures they need to produce it.

25 Apr 2026

Researchers uncover new mechanism linking metabolism, immunity, and skeletal health

Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment.

25 Apr 2026

Scientists identify STING switch driving inflammation in Alzheimer’s disease

The brain has its own immune system, which detects threats and mounts a defense. A growing body of evidence has shown that in Alzheimer's disease, those immune cells are chronically overactivated, causing inflammation that damages the connections between brain cells.

24 Apr 2026

New mouse model reveals primary trigger of rare muscle disorder

Myofibrillar myopathy type 6 (MFM6) is a rare genetic muscle disorder that leads to severe muscle weakness and a drastically shortened life expectancy due to a disruption in muscle protein regulation.

24 Apr 2026

MSK scientists shed new light on a tumor's earliest moments

Scientists at Memorial Sloan Kettering Cancer Center (MSK) and their colleagues are shedding new light on a tumor's earliest moments - revealing how lung cells with cancer-causing mutations recruit accomplices from healthy surrounding tissue to pave the way for a tumor to develop.

23 Apr 2026

Astrocytes form complex networks across the mouse brain

Cells long thought to play a secondary role in brain function build their own far-reaching connections, a new study in mice showed. These pathways appear to connect distant regions in ways that have not been mapped before.

23 Apr 2026

Antisense oligonucleotides reverse rare neurodevelopmental disorder in preclinical models

Scientists at St. Jude Children's Research Hospital have found they can reverse the effects of HNRNPH2-related neurodevelopmental disorder using antisense oligonucleotides (ASOs) in preclinical models. ASOs are short synthetic nucleic acid strands that target specific messenger RNA.

22 Apr 2026

New antibody mechanism selectively suppresses harmful immune responses

The immune system is our frontline protection against infection, continually searching for and destroying unknown pathogens.

22 Apr 2026

Calcium signals in microglia drive anxiety and compulsive behaviors

Researchers had previously discovered a population of immune cells within the brain that can act as accelerators and brakes for anxiety in mice. N

21 Apr 2026

Scientists develop MIND approach to predict and reshape microbiomes

University of California San Diego researchers have developed a new tool for understanding and modifying any microbiome, including the human microbiome.

21 Apr 2026

Serotonin may worsen tinnitus symptoms, mice study finds

The same neurotransmitter commonly leveraged to relieve symptoms of depression and anxiety also may exacerbate a vexing condition known as tinnitus, according to new research published in the Proceedings of the National Academy of Sciences.

20 Apr 2026

New gene target offers hope for fatal infant cardiomyopathy

Researchers from the Keck School of Medicine of USC have made an important advance toward understanding-and potentially treating-a rare cardiomyopathy (heart muscle disease) that is present from birth.

20 Apr 2026

Metastatic cells can be identified within primary breast tumors

Understanding which cells within a tumor will go on to form metastases remains one of the major challenges in cancer research.

20 Apr 2026

New atlas maps how the vascular network of mouse's brain grows after birth

Scientists have made a major advance in developmental neuroscience, creating the very first detailed atlas of how the vascular network of a mouse's brain grows after birth. Their study is published in Cell.

17 Apr 2026

Age shapes melanoma progression and immune response

Cancer risk increases with age and is often more aggressive and difficult to treat in older adults. However, fewer than 10% of mouse studies use aged animals, with most relying on mice roughly equivalent to humans in their early 20s.

17 Apr 2026

How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

This review argues that neurodegeneration is shaped not only by toxic protein buildup but also by immune signaling, with microglia and T cells able to either protect the brain or worsen damage depending on context. It also highlights aging, head injury, and viral infection as major forces that reshape CNS immunity and may influence disease progression and future treatment strategies.

16 Apr 2026