Radiotherapy News and Research

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Radiation therapy (in North America), or radiotherapy (in the UK and Australia) also called radiation oncology, and sometimes abbreviated to XRT, is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis).

Early trial finds promise for avelumab and radiation in treating leptomeningeal disease

Researchers at Moffitt Cancer Center have reported encouraging results from a phase 1B clinical trial showing that the immunotherapy drug avelumab, when combined with whole brain radiotherapy, may provide a safe and effective treatment option for patients with leptomeningeal disease, one of the most aggressive and difficult-to-treat complications of advanced cancer.

30 Sep 2025

Proton therapy dose escalation may improve outcomes for glioblastoma patients

Previously, results from the photon cohort of the NRG-BN001, a signal seeking Phase II randomized trial, indicated that photon radiation dose intensification (75 Gy) did not demonstrate improvement in overall survival (OS) for patients with newly diagnosed glioblastoma (GBM).

30 Sep 2025

Stereotactic radiotherapy offers long-term survival outcomes comparable to surgery for NSCLC patients

A new clinical trial report finds that stereotactic radiation therapy offers long-term survival outcomes comparable to surgery for patients with small, early-stage non-small cell lung cancer (NSCLC). Patients in the study who received radiation also reported fewer side effects after treatment.

30 Sep 2025

Discovery of EUDAL reveals new mechanism behind chemotherapy resistance in oral cancer

Oral cancer is one of the most common head and neck cancers worldwide, with hundreds of thousands of new cases diagnosed every year. Despite advances in surgery, radiotherapy, and chemotherapy, survival rates remain poor.

30 Sep 2025

Proton therapy offers no significant QOL advantage over photon therapy for breast cancer

The first randomized trial to compare photon- and proton-based radiation therapy for breast cancer finds that patients report equally strong health-related quality of life with either treatment. Patients who received proton therapy were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.

30 Sep 2025

Tissue-mimicking hydrogels drive cell reprogramming via matrix remodeling

The mechanical properties of tissue matrix are crucial for maintaining cell health and function. With aging, tissue matrix loses its mechanical integrity and exhibits altered biophysical properties, which are closely associated with various diseases including neurodegenerative diseases and cancers.

30 Sep 2025

Radiation therapy shows promise as safer alternative for severe heart rhythm disorder

Radiation therapy may offer a comparable and potentially safer alternative to repeat catheter ablation for patients with severe abnormal heart rhythms that can no longer be controlled with medication.

29 Sep 2025

Post-operative radiation therapy reduces pelvic relapse in high-risk bladder cancer

Radiation therapy could be an underused tool to reduce pelvic relapse risk for patients with locally advanced, muscle-invasive bladder cancer, according to results of a new phase III randomized trial.

29 Sep 2025

Proton therapy and IMRT show similar outcomes in head and neck cancer trial

A new phase III clinical trial finds that intensity-modulated radiation therapy (IMRT) and proton beam therapy resulted in similar quality-of-life outcomes and low rates of side effects for people with locally advanced oropharyngeal cancer.

29 Sep 2025

Gene expression test identifies prostate cancer patients who benefit from hormone therapy

A new randomized study finds that a lab test that reads tumor genes can identify which patients with recurrent prostate cancer will benefit from adding hormone therapy to radiation after surgery - the first predictive biomarker in this setting.

29 Sep 2025

Combining radiopharmaceuticals with targeted radiation improves progression-free survival in prostate cancer patients

A new clinical trial finds that people with a limited number of metastases from recurrent prostate cancer lived significantly longer without disease progression when they received a radiopharmaceutical drug before targeted radiation, compared with radiation alone.

29 Sep 2025

UCLA presents advances in radiation therapy at ASTRO 2025

Physicians and scientists from the UCLA Health Jonsson Comprehensive Cancer Center will share the latest research and clinical trial results at the 2025 American Society for Radiation Oncology (ASTRO) Annual Meeting, including studies on targeted radioactive therapy for recurrent prostate cancer, new approaches to stereotactic body radiation for prostate and head and neck cancers, advances in MRI- and 5DCT-guided imaging for more precise treatments, and innovations in patient-focused cancer education.

26 Sep 2025

Novel treatment disrupts tumor immunosuppression in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with a five-year survival rate below 10%.

26 Sep 2025

COST Actions drive innovation in cancer research across Europe

Cancer is a major challenge in the modern world, affecting millions of people across Europe. The prevalence of this disease requires the development of innovative and complementary treatment approaches.

19 Sep 2025

Genomic testing speeds patient accrual in high-risk prostate cancer trial

The NRG Oncology NRG-GU009 (PREDICT-RT) study evaluating intensified and de-intensified concurrent radiation regimens based on the genomic risk of patients with high-risk prostate cancer completed accrual and met its accrual milestone of 2,478 patients approximately two years earlier than the trial's anticipated accrual completion date.

19 Sep 2025

Uterine corpus malignancies with pregnancy-like features lead to poor survival outcomes

A new review was published in Volume 12 of Oncoscience on September 4, 2025, titled "Prognostic significance of trophoblastic differentiation and β-hCG secretion in somatic malignancies of uterine corpus: A systematic review with survival analysis."

16 Sep 2025

Novel biotechnical vector integrates viral and synthetic features for targeted cancer therapy

Gene therapy offers the possibility of addressing cancer at its molecular roots by targeting disease-causing genes rather than relying solely on surgery, chemotherapy, or radiotherapy.

16 Sep 2025

Can high-protein supplements improve cancer recovery?

A systematic review shows high-protein oral nutritional supplements can lower complications and hospital stays in cancer patients, improving recovery outcomes.

16 Sep 2025

Mapping the evolutionary trajectory of meningiomas at single-cell resolution

Meningiomas are the most common primary brain tumors, accounting for nearly one-third of all central nervous system (CNS) tumors.

11 Sep 2025

Survey shows ongoing misconceptions about hormone therapy safety in cancer survivors

Despite evidence suggesting the safety of hormone therapy for patients with a history of low-grade endometrial or epithelial ovarian cancer, a new survey shows that many gynecologists and some gynecologic oncologists are still uncomfortable prescribing the therapy for this patient population.

10 Sep 2025

Radiotherapy News and Research

Further Reading

Early trial finds promise for avelumab and radiation in treating leptomeningeal disease

Proton therapy dose escalation may improve outcomes for glioblastoma patients

Stereotactic radiotherapy offers long-term survival outcomes comparable to surgery for NSCLC patients

Discovery of EUDAL reveals new mechanism behind chemotherapy resistance in oral cancer

Proton therapy offers no significant QOL advantage over photon therapy for breast cancer

Tissue-mimicking hydrogels drive cell reprogramming via matrix remodeling

Radiation therapy shows promise as safer alternative for severe heart rhythm disorder

Post-operative radiation therapy reduces pelvic relapse in high-risk bladder cancer

Proton therapy and IMRT show similar outcomes in head and neck cancer trial

Gene expression test identifies prostate cancer patients who benefit from hormone therapy

Combining radiopharmaceuticals with targeted radiation improves progression-free survival in prostate cancer patients

UCLA presents advances in radiation therapy at ASTRO 2025

Novel treatment disrupts tumor immunosuppression in pancreatic cancer

COST Actions drive innovation in cancer research across Europe

Genomic testing speeds patient accrual in high-risk prostate cancer trial

Uterine corpus malignancies with pregnancy-like features lead to poor survival outcomes

Novel biotechnical vector integrates viral and synthetic features for targeted cancer therapy

Can high-protein supplements improve cancer recovery?

Mapping the evolutionary trajectory of meningiomas at single-cell resolution

Survey shows ongoing misconceptions about hormone therapy safety in cancer survivors

Cancer Research - Second Edition eBook

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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