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Abnormal levels of metabolites can reliably predict lung disease in 9/11 firefighters

Abnormal levels of more than two dozen metabolites - chemicals produced in the body as it breaks down fats, proteins and carbohydrates - can reliably predict which Sept. 11 firefighters developed lung disease and which did not, a new analysis shows.

4 Sep 2018

Sunovion receives Complete Response Letter from FDA for dasotraline NDA

Sunovion Pharmaceuticals Inc. today announced that the U.S. Food and Drug Administration issued a Complete Response Letter for the New Drug Application for dasotraline, a novel dual-acting dopamine and norepinephrine reuptake inhibitor, for the treatment of attention-deficit hyperactivity disorder.

3 Sep 2018

Early childhood growth patterns affect respiratory health

Children's growth in the first three years of life affects the development of their lungs and the risk of asthma at 10 years of age.

31 Aug 2018

Researchers use computational analysis to identify new phenotype of severe malaria

There are more clinical phenotypes of severe malaria than those defined by the World Health Organization, according to a study led by ISGlobal, an institution supported by "la Caixa" Foundation.

31 Aug 2018

Newborns require special diagnosis and treatment considerations for C. difficile infection

Newborns require special diagnosis and treatment considerations for an infectious diarrhea known as Clostridioides difficile infection, according to a new evidence-based white paper published today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.

31 Aug 2018

New guideline developed to help physicians diagnose idiopathic pulmonary fibrosis

A new international guideline has been developed to help physicians diagnosis idiopathic pulmonary fibrosis, a rare and often fatal lung disease whose cause is unknown.

31 Aug 2018

Muscle dystrophy treatment in dogs with Crispr gene editing

Researchers in the United States have shown that genetically caused muscular dystrophy in dogs could be corrected using genetic editing tools. Muscular dystrophy is one of the most common fatal genetic conditions seen in children and is also seen in dogs

31 Aug 2018

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Pfizer Inc. announced today that it is terminating two ongoing clinical studies evaluating domagrozumab (PF-06252616) for the treatment of Duchenne muscular dystrophy (DMD): a Phase 2 safety and efficacy study (B5161002) and an open-label extension study (B5161004).

30 Aug 2018

SMA treatment may be effective even if started in children seven months and older

A drug shown to be effective in the treatment of babies with the rare muscle-wasting disease spinal muscular atrophy may be effective for muscle control even when treatment is started in children seven months and older, according to a study published in the August 29, 2018, online issue of Neurology, the medical journal of the American Academy of Neurology. Previous studies focused on children younger than seven months old.

30 Aug 2018

Researchers take major step forward in finding safe and non-addictive pain killer

With the support of the National Institute on Drug Abuse, scientists at Wake Forest School of Medicine have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country.

30 Aug 2018

Scientists reveal how immune system strives to protect the lungs of infants with flu

The immune system appears to put a premium on maintaining lung function in infants infected with the influenza virus by mounting a rapid response to repair damaged cells, according to research led by St. Jude Children’s Research Hospital. The findings appear today in the scientific journal Immunity.

29 Aug 2018

Scientists develop three-pronged model to predict ARDS in burn patients

For the first time, researchers have devised a model to predict burn patients who are most likely to develop life-threatening acute respiratory distress syndrome.

28 Aug 2018

Pediatric researchers discover gene mutation that causes lymphatic disorder

Pediatric researchers have identified a gene mutation that causes a serious lymphatic condition, and used that knowledge to restore normal lymphatic vessels in model animals. The laboratory findings may lead to a new therapy for patients with this type of abnormal lymphatic circulation.

28 Aug 2018

Teleflex enrolls first patient in clinical study of CleanSweep Closed Suction System

Teleflex Incorporated, a leading global provider of medical technologies for critical care and surgery, today announced the first patient enrollment in a U.S. clinical study of CleanSweep Closed Suction System at Duke University Hospital in Durham, NC.

28 Aug 2018

New report estimates that about 36,000 people die due to air pollution every year in the UK

A new report led by King's and published by the government's Committee on the Medical Effects of Air Pollutants estimates that between 28,000 and 36,000 people die as a result of air pollution every year in the UK.

28 Aug 2018

New safety guideline released for prescribing biological therapies in inflammatory arthritis

The British Society for Rheumatology publishes its latest clinical guideline in Rheumatology, the UK’s key specialist journal in the sector. The new guideline updates and presents two previous guidelines into one set of evidence based recommendations on the vital safety aspects of prescribing biological therapies in inflammatory arthritis.

28 Aug 2018

Drug overdose continues to be a significant cause of death in Australia

A new report has come up with alarming numbers of deaths due to drug overdose among Australians. The report states that common sedatives and sleeping pills may be responsible for over 142 deaths each month due to their overdose.

27 Aug 2018

Evotec collaborates with CENTOGENE to develop compounds to treat rare genetic diseases

CENTOGENE today announced that Evotec AG and CENTOGENE AG entered into a global strategic collaboration agreement for joint drug discovery projects, developing compounds to treat rare genetic diseases.

27 Aug 2018

Study: 1 in 12 children taking multiple medications at risk of drug-drug interactions

According to new research from the University of Illinois at Chicago, about one in five children regularly use prescription medications, and nearly one in 12 of those children are at risk for experiencing a harmful drug-drug interaction.

27 Aug 2018

Oral anticoagulant use after hospital discharge may offer protection from non-fatal blood clots

The use of an oral anticoagulant medicine in medically ill patients for 45 days following their discharge from the hospital reduces the rate of non-fatal symptomatic blood clots with no impact on fatal blood clots, according to late breaking results from the MARINER trial presented today in a Hot Line Session at ESC Congress 2018 and published in The New England Journal of Medicine.

27 Aug 2018

Respiratory News and Research

Abnormal levels of metabolites can reliably predict lung disease in 9/11 firefighters

Sunovion receives Complete Response Letter from FDA for dasotraline NDA

Early childhood growth patterns affect respiratory health

Researchers use computational analysis to identify new phenotype of severe malaria

Newborns require special diagnosis and treatment considerations for C. difficile infection

New guideline developed to help physicians diagnose idiopathic pulmonary fibrosis

Muscle dystrophy treatment in dogs with Crispr gene editing

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

SMA treatment may be effective even if started in children seven months and older

Researchers take major step forward in finding safe and non-addictive pain killer

Scientists reveal how immune system strives to protect the lungs of infants with flu

Scientists develop three-pronged model to predict ARDS in burn patients

Pediatric researchers discover gene mutation that causes lymphatic disorder

Teleflex enrolls first patient in clinical study of CleanSweep Closed Suction System

New report estimates that about 36,000 people die due to air pollution every year in the UK

New safety guideline released for prescribing biological therapies in inflammatory arthritis

Drug overdose continues to be a significant cause of death in Australia

Evotec collaborates with CENTOGENE to develop compounds to treat rare genetic diseases

Study: 1 in 12 children taking multiple medications at risk of drug-drug interactions

Oral anticoagulant use after hospital discharge may offer protection from non-fatal blood clots

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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