Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Biognosys announces strategic agreement with Siemens Healthineers

Biognosys announces today that it has established a strategic agreement with Siemens Healthineers through its clinical laboratory in Berkeley, California.

From Biognosys 14 Apr 2021

Study of antiviral nutraceutical phenolics against SARS-CoV-2 main protease

To address this issue, a team of researchers led by Professor Mohamed El Raey of the National Research Centre, Dokki, Cairo, Egypt, looked at phytopharmaceuticals and nutraceuticals as potential antivirals against SARS-CoV-2.

13 Apr 2021

Previously approved drugs starting points for COVID-19 therapeutics

Researchers in the United States have identified several clinically approved compounds that could be repurposed for the treatment and prevention of coronavirus disease 2019 (COVID-19).

11 Apr 2021

Researchers use genetics to identify potential drugs for early management of COVID-19

A new study using human genetics suggests researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages.

9 Apr 2021

Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions.

9 Apr 2021

New time-lapse system helps measure membrane tension

Ion channels play an indispensable role in cellular physiology, and understanding the physical features that affect ion channel functions is a matter of considerable interest to biologists.

9 Apr 2021

Solvation cages may lead to more efficient operation of high-voltage battery cells

Membranes that allow certain molecules to quickly pass through while blocking others are key enablers for energy technologies from batteries and fuel cells to resource refinement and water purification.

8 Apr 2021

First-of-its-kind study identifies 13 new Alzheimer’s disease genes

In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer's disease (AD), researchers have identified 13 such variants (or mutations).

3 Apr 2021

SwiftScale Biologics: Cell-Free Synthesis of Biologics

In this interview, News-Medical talks to David Mace, CEO at SwiftScale Biologics, about the work they do in cell-free synthesis, their partnership with Sartorius and the biologics field as a whole.

From Sartorius 30 Mar 2021

Linear epitope mapping of the SARS-CoV-2 spike protein

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the primary target of many drug discovery efforts and is similarly utilized in each of the approved COVID-19 vaccines to elicit the generation of anti-spike protein antibodies, thereby granting immunity.

28 Mar 2021

Boerhavia diffusa possess potential therapeutic properties against COVID-19

Several companies and research groups have been searching for suitably docking ligands that inhibit the function of this protein. In a research paper recently published to the Springer journal VirusDisease by Surya & Praveen (March 6th, 2021) in silico docking simulations towards 3CLpro have been performed, focusing in particular on natural products obtained from the plant Boerhavia diffusa.

28 Mar 2021

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

University of Birmingham researchers are working to isolate and extract the COVID-19 encounter complex in a form that is stable enough for identification of target sites for future anti-viral drugs.

27 Mar 2021

UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes

A University of Arizona Health Sciences researcher examined the role of cholesterol in both Alzheimer's disease and Type 2 diabetes to identify a small molecule that may help regulate cholesterol levels in the brain, making it a potential new therapeutic target for Alzheimer's disease.

25 Mar 2021

Study reveals new approach for treating diabetic foot ulcers

A discovery involving multiple teams from across Scripps Research has revealed a powerful new approach for treating diabetic foot ulcers, which affect millions of people in the US and often lead to serious complications.

23 Mar 2021

Investments in life sciences can be appealing to many investors as vaccines are rolled out

The past twelve months have showcased the importance of medical developments like never before. Innovation in the life sciences sector has been headline news around the globe and all aspects of the healthcare system have been under the microscope.

22 Mar 2021

Insights into elusive protein complex can help find novel treatments for chromosomal disorders

The cells in our body are constantly fighting off the threat of cancer by repairing damaged DNA. In a new study, scientists from Tokyo University of Science investigate the structure of an elusive protein complex that plays a key role in the activation of the "Fanconi anemia pathway" involved in DNA repair, and report on the factors governing its stability.

17 Mar 2021

INTEGRA’s VOYAGER adjustable tip spacing pipettes streamline the production of venom-based screening assays

Venomtech® – a leading UK-based biotechnology company founded in 2010 – is harnessing the power of natural venoms produced by animals to generate compound libraries that are used in drug discovery studies.

From INTEGRA Biosciences 17 Mar 2021

Axol Bioscience and Censo Biotechnologies Announce Merger

Axol Bioscience Ltd and CENSO Biotechnologies today announced that the two companies have signed a merger agreement.

From Axol Bioscience Ltd 17 Mar 2021

Newly identified drugs can help treat oral and esophageal carcinomas

Discovering and treating tumors before they spread throughout the body is key for cancer patients to achieve positive outcomes. When tumor cells spread, which is known as metastasis, they can take over other organs and lead to death.

17 Mar 2021

Study could lead to the development of novel treatments for drug-resistant cancers

ETC-159, a made-in-Singapore anti-cancer drug that is currently in early phase clinical trials for use in a subset of colorectal and gynecological cancers, could also prevent some tumors from resisting therapies by blocking a key DNA repair mechanism, researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research in Singapore reported in the journal EMBO Molecular Medicine.

16 Mar 2021

Drug Discovery News and Research

Further Reading

Biognosys announces strategic agreement with Siemens Healthineers

Study of antiviral nutraceutical phenolics against SARS-CoV-2 main protease

Previously approved drugs starting points for COVID-19 therapeutics

Researchers use genetics to identify potential drugs for early management of COVID-19

Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

New time-lapse system helps measure membrane tension

Solvation cages may lead to more efficient operation of high-voltage battery cells

First-of-its-kind study identifies 13 new Alzheimer’s disease genes

SwiftScale Biologics: Cell-Free Synthesis of Biologics

Linear epitope mapping of the SARS-CoV-2 spike protein

Boerhavia diffusa possess potential therapeutic properties against COVID-19

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes

Study reveals new approach for treating diabetic foot ulcers

Investments in life sciences can be appealing to many investors as vaccines are rolled out

Insights into elusive protein complex can help find novel treatments for chromosomal disorders

INTEGRA’s VOYAGER adjustable tip spacing pipettes streamline the production of venom-based screening assays

Axol Bioscience and Censo Biotechnologies Announce Merger

Newly identified drugs can help treat oral and esophageal carcinomas

Study could lead to the development of novel treatments for drug-resistant cancers

eBook: Image-guided automated cell culture for 2D, iPSC, and organoid workflows eBook

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