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Early intervention with TAVR proves safe and effective for asymptomatic aortic stenosis

The first powered randomized trial examining early intervention with transcatheter aortic valve replacement (TAVR) in patients with asymptomatic, severe aortic stenosis (AS) found this strategy to be both a safe and effective alternative to clinical surveillance (CS).

29 Oct 2024

Study finds no benefit of routine orbital atherectomy in cardiac stenting

Routine use of an orbital atherectomy device to remove calcium from severely blocked coronary arteries before patients undergo cardiac stenting procedures does not improve outcomes, a Mount Sinai-led study has found.

29 Oct 2024

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

In this interview, conducted at SfN 2024 in Chicago, News Medical speaks with Joel Svensson and Carolyn Marks of Atlas Antibodies, about their new launch, the MolBoolean™, as well as how conferences like SfN are helping shape the future of neuroscience research.

From Atlas Antibodies AB 29 Oct 2024

Study identifies six cancer susceptibility genes

Identification of six cancer susceptibility genes offers new insights into genetic risk factors, potentially enhancing early detection and treatment strategies.

29 Oct 2024

Global leaders gather at the NFCR Summit to drive breakthroughs in cancer care

The 2024 National Foundation for Cancer Research (NFCR) Global Summit and Award Ceremonies for Cancer Research & Entrepreneurship, co-hosted with the AIM-HI Accelerator Fund, convened the world's top experts across cancer research, biotech entrepreneurship, pharmaceuticals, investment, and patient advocacy.

28 Oct 2024

Researchers discover key biochemical mechanism in Huntington's disease development

Researchers from the University of Oxford have identified a key biochemical mechanism relevant to the development of Huntington's Disease.

28 Oct 2024

Novel gene therapy PS-002 targets podocytes in IgA nephropathy

IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition's pathogenesis.

27 Oct 2024

Research uncovers how parasitic worms evade itch response

Ever had an itchy nose or, worse, an unreachable spot on your back that drives you mad? Now imagine an itch that refuses to go away, no matter how hard or long you scratch.

26 Oct 2024

Study sheds new light on p53 tumor suppressor gene's role in ulcerative colitis

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis.

26 Oct 2024

Discovery of stem-like CD4 T cells offers new hope for cancer immunotherapy

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity.

26 Oct 2024

Tertiary lymphoid structures linked to improved outcomes in liver cancer patients

A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center.

25 Oct 2024

Researchers unlock potential of light-controlled cellular activities

Researchers at the Paul Scherrer Institute PSI have succeeded in elucidating the structure of specific photoreceptors.

25 Oct 2024

Key mutations discovered in cancer cells linked to WRN inhibitor resistance

Researchers have discovered key mutations in certain cancer cells that make them resistant to WRN inhibitors, a new class of anti-cancer drugs.

24 Oct 2024

New drug TYRA-300 shows effectiveness in treating metastatic bladder cancer

Patients with advanced bladder cancer that had spread to other parts of the body (metastasized) have responded well in a phase I clinical trial of an investigational drug, TYRA-300.

24 Oct 2024

Mini-protein AKY-1189 delivers targeted radiation to tumor cells

Researchers have shown for the first time that it is possible for a specially-designed 'mini-protein' to deliver a radiation dose directly to tumour cells expressing a protein on their cell surfaces called Nectin-4, which is often found in a number of different cancers.

24 Oct 2024

FarrSight-Twin technology transforms cancer treatment research

Researchers have shown that they can accurately re-create clinical trials of new treatments using 'digital twins' of real cancer patients.

24 Oct 2024

Gut health and diet: Keys to treating acne, alopecia, and dermatitis

Consuming diets rich in fiber, antioxidants, and phytonutrients, combined with the use of probiotics, synbiotics, and postbiotics, improves overall skin health.

24 Oct 2024

New antibody platform targets evolving viruses

Scientists at the Icahn School of Medicine at Mount Sinai, in collaboration with colleagues in the field, have developed an innovative antibody platform aimed at tackling one of the greatest challenges in treating rapidly evolving viruses like SARS-CoV-2: their ability to mutate and evade existing vaccines and therapies.

23 Oct 2024

myeloMATCH program opens enrollment for acute myeloid leukemia and MDS

Four leading cancer research organizations in the United States and Canada announce the opening of patient enrollment to myeloMATCH, a unique portfolio of clinical trials to test precision medicine treatments for adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

23 Oct 2024

HER2-postive breast cancer drugs show promise for bile duct cancer treatment

Drugs designed to target HER2-postive breast cancer could also benefit some patients with bile duct cancer, according to results of a patient trial to be presented on Thursday at the 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain.

23 Oct 2024